In this article, the author aims to explore the place and role of American-Ethiopian relations in US geopolitical strategies. The scientific novelty lies in a comprehensive analysis of the American-Ethiopian relations on the East African region in the context of US foreign policy. Research methods. Historical-genetic method is used in the article, which gave an opportunity to explore the genesis of East African politics of the USA, to identify the main tendencies of this policy direction at every stage. A systematic approach was used for the comprehensive analysis of the USA East Africa policy in 1965–1967, which gave an opportunity to identify economic and geopolitical interests of the USA in East Africa, goals and objectives of major counties towards Ethiopia, and to trace in this regard the attitude of the USA towards Ethiopia’s confrontation with Somalia and Eritrea. Conclusions. Despite the orientation of the Foreign policy of the emperor of Ethiopia to the USA and his attempts to satisfy the USA interests (including the allocation of a military base in Ethiopia), Haile Selassie I failed to fully attract not only American private fund but also to make Ethiopia one of the Foreign policy priorities of the USA government. Ethiopia was of no interest to the USA not only as a potential economic partner (it remained an agricultural country with obsolete modes of production), but also as a military ally. The USA supported some plans of the emperor of Ethiopia, for example the project of accession of Eritrea to the Ethiopian Empire, for the following reasons only: due to independent Eritrean country’s insolvency due to the necessity to maintain peace and order in the Northeastern Africa, on the west coast of the Red Sea. «Right» was given to the Ethiopian Empire, which needed the access to the sea and which at that time had a relatively strong army capable to battle any inner reaction and to defend the borders of Eritrea, where American military bases were located.