The purpose of the article is to consider the issues of geological and geophysical interpretation of the data of balloon and satellite magnetic measurements along the regional profile crossing the territory of the Angara-Baikal region. In order to conduct scientific research along the regional Trans-Siberian geological and geophysical profile A-B the author used various geological and geophysical materials including the magnetic field digital data measured by the MAGSAT artificial Earth satellite and a balloon; data on the values of the electrical resistivity in the mantle of this region; geothermal data; seismic data on the location of earthquake hypocenters in the area of the profile under investigation. The research methods involved multilevel measurements of satellite and balloon magnetic fields, which significantly expanded the possibilities of geological and geophysical interpretation of the data obtained. The conducted study revealed that the geological and geophysical interpretation of multilevel aeromagnetic data allows for a reasonably accurate determination of the location coordinates and lithospheric penetration depth of tectonic faults associated with the Angara and Trans-Baikal mantle plumes, which are of significant interest in terms of exploration of coal and uranium deposits. The spatial and depth characteristics of tectonic faults obtained from balloon and satellite data are confirmed by a set of analyzed independent geophysical data: magnetotelluric sounding, geothermy, seismology and other geophysical methods. In conclusion it should be noted that the author has demonstrated the application possibility of satellite and balloon magnetic surveys for the study of the deep structure of the Angara and Trans-Baikal mantle plumes. In addition, it was found out that according to balloon and satellite magnetic data, large deep tectonic faults in the lithosphere (Barguzinsky, Ikatsky, Tukolamsky, Tungirsky) can be identified, which also allow marking various subhorizontal boundaries of lithospheric layers in the location area of the Angara and Trans-Baikal mantle plumes using special points of the magnetically active zones of these faults. The practical significance of the conducted research is in the identification of the spatial relationship between the location of the Angara mantle plume and coal deposits of the Irkutsk basin, as well as uranium deposits in the zone of the Trans-Baikal mantle plume.