Simple Geometry Research Articles

Simplified single-shot geometries for quantitative phase imaging using transport of intensity equation

Simplified single-shot geometries for quantitative phase imaging using transport of intensity equation

On the use of simplified geometries to represent turbulent flow over coral reefs

Hydrodynamic consequences of using simpler geometric shapes to represent coral canopies are examined through a laboratory study. A canopy composed of cylinders is compared with a canopy composed of 3-D-printed, scaled down coral heads in a recirculating flume. Vertical velocity profiles are measured at four horizontal locations for each canopy type, and mean velocity and turbulence statistics are compared both within and above the canopy. A narrow, defined wake on the scale of the canopy element is present behind the cylinder canopy elements that is absent in the coral canopy. There is also a peak in shear stress at the top of the cylinder canopy, likely due to the sharp edge at the top of the cylinder. Above the canopy, however, turbulence statistics and friction velocities behave similarly for both canopy types. Therefore, the results indicate we may reasonably get coral reef drag estimates from canopies with simpler geometric surrogates, especially when the mean free-stream and within-canopy flow speeds are matched to environmental conditions.

Heat and Mass Transfer in Shrimp Hot-Air Drying: Experimental Evaluation and Numerical Simulation

Shrimp is one of the most popular and widely consumed seafood products worldwide. It is highly perishable due to its high moisture content. Thus, dehydration is commonly used to extend its shelf life, mostly via air drying, leading to a temperature increase, moisture removal, and matrix shrinkage. In this study, a mathematical model was developed to describe the changes in moisture and temperature distribution in shrimp during hot-air drying. The model considered the heat and mass transfer in an irregular-shaped computational domain and was solved using the finite element method. Convective heat and mass transfer coefficients (57.0–62.9 W/m2∙K and 0.007–0.008 m/s, respectively) and the moisture effective diffusion coefficient (6.5 × 10−10–8.5 × 10−10 m2/s) were determined experimentally and numerically. The shrimp temperature and moisture numerical solution were validated using a cabinet dryer with a forced air circulation at 60 and 70 °C. The model predictions demonstrated close agreement with the experimental data (R2≥ 0.95 for all conditions) and revealed three distinct drying stages: initial warming up, constant drying rate, and falling drying rate at the end. Initially, the shrimp temperature increased from 25 °C to around 46 °C and 53 °C for the process at 60 °C and 70 °C. Thus, it presented a constant drying rate, around 0.04 kg/kg min at 60 °C and 0.05 kg/kg min at 70 °C. During this stage, the process is controlled by the heat transferred from the surroundings. Subsequently, the internal resistance to mass transfer becomes the dominant factor, leading to a decrease in the drying rate and an increase in temperatures. A numerical analysis indicated that considering the irregular shape of the shrimp provides more realistic moisture and temperature profiles compared to the simplified finite cylinder geometry. Furthermore, a sensitivity analysis was performed using the validated model to assess the impact of the mass and heat transfer parameters and relative humidity inside the cavity on the drying process. The proposed model accurately described the drying, allowing the further evaluation of the quality and safety aspects and optimizing the process.

Biomechanical Optimization of the Human Bite Using Numerical Analysis Based on the Finite Element Method

Biomechanical bite analysis is essential for understanding occlusal forces and their distribution, especially in the design and validation of dental prostheses. Although the finite element method (FEM) has been widely used to evaluate these forces, the existing models often lack accuracy due to simplified geometries and limited material properties. Methods: A detailed finite element model was developed using Abaqus Standard 2023 software (Dassault Systemes, Vélizy-Villacoublay, France), incorporating scanned 3D geometries of mandibular and maxillary bones. The model included cortical and cancellous bones (Young’s modulus: 5.5 GPa and 13.7 GPa, respectively) and was adjusted to simulate bite forces of 220.7 N based on experimental data. Occlusal forces were evaluated using flexible connectors that replicate molar-to-molar interactions, and the stress state was analyzed in the maxillary and mandibular bones. Results: The FEM model consisted of 1.68 million elements, with mesh sizes of 1–1.5 mm in critical areas. Bite forces on the molars were consistent with clinical trials: first molar (59.3 N), second molar (34.4 N), and third molar (16.7 N). The results showed that the maximum principal stresses in the maxillary bones did not exceed ±5 MPa, validating the robustness of the model for biomechanical predictions. Conclusion: The developed model provides an accurate and validated framework for analyzing the distribution of occlusal forces in intact dentures. This approach allows the evaluation of complex prosthetic configurations and their biomechanical impact, optimizing future designs to reduce clinical complications and improve long-term outcomes. The integration of high-resolution FEM models with clinical data establishes a solid foundation for the development of predictive tools in restorative dentistry.

Pulse-by-pulse treatment planning and its application to generic observations of ultra-high dose rate (FLASH) radiotherapy with photons and protons.

The exact temporal characteristics of beam delivery affect the efficacy and outcome of ultra-high dose rate (UHDR or "FLASH") radiotherapy, mainly due to the influence of the beam pulse structure on mean dose rate. Single beams may also be delivered in separate treatment sessions to elevate mean dose rate. This paper therefore describes a model for pulse-by-pulse treatment planning and demonstrates its application by making some generic observations of the characteristics of FLASH radiotherapy with photons and protons.

Approach. A beam delivery model was implemented into the AutoBeam (v6.3) inverse treatment planning system, so that the individual pulses of the delivery system could be explicitly described during optimisation. The delivery model was used to calculate distributions of time-averaged and dose-averaged mean dose rate and the dose modifying factor for FLASH was then determined and applied to dose calculated by a discrete ordinates Boltzmann solver. The method was applied to intensity-modulated radiation therapy (IMRT) with photons as well as to passive scattering and pencil beam scanning with protons for the case of a simple phantom geometry with a prescribed dose of 36 Gy in 3 fractions.

Main results. Dose and dose rate are highest in the target region, so FLASH sparing is most pronounced around the planning target volume. When using a treatment session per beam, OAR sparing is possible more peripherally. The sparing with photons is higher than with protons because the dose to OAR is higher with photons.

Significance. The framework provides an efficient method to determine the optimal technique for delivering clinical dose distributions using FLASH. The most sparing occurs close to the PTV for hypofractionated treatments.&#xD.

CFD Simulation and Statistical Analysis of Experimental Designs for Blood Flow in T-Junction Vessels

<p><strong>The blood vessel area that has the greatest chance of atherosclerotic plaque deposition is the bifurcation zone (branching) in the carotid artery. The non-Newtonian fluid of blood has the characteristics of a shear-thinning fluid. Computational Fluid Dynamics (CFD) simulation is used in this study to analyse hemodynamic in carotid artery flow with variations of vessel geometry. The branching geometry of the arteries is represented by a T-junction model which is the ideal simplified blood vessel geometry model to exhibit the most common behaviour in arterial bifurcations. The geometry of the T branch is varied into 4 different combinations of diameter size. Thus, the 2k factorial experimental design method is also used to investigate the effect of the inflow and outflow domain sizes on the response variables in the form of velocity values, Wall Shear Stress (WSS), and Oscillatory Shear Index (OSI). The results of this simulation can greatly help medical scientists to more easily predict areas that have the potential to form atherosclerotic plaques in the circulatory system.</strong></p><p><strong><em>Keywords</em></strong> - <em>Atherosclerotic Plaque, Blood Vessel, Computational Fluid Dynamics Non-Newtonian Fluid, 2k Factorial Method</em>.</p>

BiOI: Self‐Powered Humidity Sensor and Breath Monitor

AbstractThe self‐powered, adaptable, quick, and precise humidity sensors are required to measure humidity in the microenvironment. Here, a simple one‐step wet chemical method is presented to prepare stacked layered bismuth oxyiodide (BiOI) nanoplates. The remarkable response and self‐powered behavior of BiOI nanoplates‐based humidity sensors are demonstrated for the first time. The humidity sensing characteristics of BiOI are examined within the range of 30–80% relative humidity (RH) at an operating temperature of 323 K. The highest sensitivity level of 39 kΩ per %RH is determined for a relative humidity of 75.5%. A successful attempt is made to use this sensor as a human breathing process monitor. The sensor response times at room temperature in this test are 3.04(9) s at 0 V and 3.31(7) s at 20 V, whereas the recovery times are estimated to be 6.57(6) s at 0 V and 6.42(4) s at 20 V. Future advancements in sensing devices utilizing BiOI hold the potential to yield highly responsive, ultrafast sensors with simplified device geometries, and self‐powered.

Speckle-illumination spatial frequency domain imaging with a stereo laparoscope for profile-corrected optical property mapping.

Laparoscopic surgery presents challenges in localizing oncological margins due to poor contrast between healthy and malignant tissues. Optical properties can uniquely identify various tissue types and disease states with high sensitivity and specificity, making it a promising tool for surgical guidance. Although spatial frequency domain imaging (SFDI) effectively measures quantitative optical properties, its deployment in laparoscopy is challenging due to the constrained imaging environment. Thus, there is a need for compact structured illumination techniques to enable accurate, quantitative endogenous contrast in minimally invasive surgery. We introduce a compact, two-camera laparoscope that incorporates both active stereo depth estimation and speckle-illumination SFDI (si-SFDI) to map profile-corrected, pixel-level absorption ( ), and reduced scattering ( ) optical properties in images of tissues with complex geometries. We used a multimode fiber-coupled 639-nm laser illumination to generate high-contrast speckle patterns on the object. These patterns were imaged through a modified commercial stereo laparoscope for optical property estimation via si-SFDI. Compared with the original si-SFDI work, which required images of randomized speckle patterns for accurate optical property estimations, our approach approximates the DC response using a laser speckle reducer (LSR) and consequently requires only two images. In addition, we demonstrate 3D profilometry using active stereo from low-coherence RGB laser flood illumination. Sample topography was then used to correct for measured intensity variations caused by object height and surface angle differences with respect to a calibration phantom. The low-contrast RGB speckle pattern was blurred using an LSR to approximate incoherent white light illumination. We validated profile-corrected si-SFDI against conventional SFDI in phantoms with simple and complex geometries, as well as in a human finger in vivo time-series constriction study. Laparoscopic si-SFDI optical property measurements agreed with conventional SFDI measurements when measuring flat tissue phantoms, exhibiting an error of 6.4% for absorption and 5.8% for reduced scattering. Profile-correction improved the accuracy for measurements of phantoms with complex geometries, particularly for absorption, where it reduced the error by 23.7%. An in vivo finger constriction study further validated laparoscopic si-SFDI, demonstrating an error of 8.2% for absorption and 5.8% for reduced scattering compared with conventional SFDI. Moreover, the observed trends in optical properties due to physiological changes were consistent with previous studies. Our stereo-laparoscopic implementation of si-SFDI provides a simple method to obtain accurate optical property maps through a laparoscope for flat and complex geometries. This has the potential to provide quantitative endogenous contrast for minimally invasive surgical guidance.

Development of a Simplified Human Body Model for Movement Simulations

The main goal of this paper is to develop a simplified model of the human body motion system that enables its application for movement simulations and the analysis of the kinematic and dynamic parameters occurring during the performance of activities. The model is established on the basis of the modified Hanavan model and consists of rigid solids with simple geometry that are connected mostly with spherical joints. Based on anthropometric data from the literature, a complete set of equations parameterizing the dimensions and mass of each segment was formulated. The equations depend on only two body measurements (height and mass). The model is built in the Adams system as a 3D numerical dynamic model and tested using data gathered with an IMU sensors system. A volunteer lifting an object with a bent spine from the ground with both hands is used for this purpose. Three angles (from the IMUs) are applied to each model’s joint to best simulate human movement and to analyze the angular displacements, velocities, and torques. These results are consistent with theoretical expectations and assumptions, thus proving that reproducing human movements with the developed model is possible and that it also allows various parameters of the human body to be obtained.

A Method for Validating PET and SPECT Cameras for Quantitative Clinical Imaging Trials Using Novel Radionuclides.

Our aim is to report methodology that has been developed to calibrate and verify PET and SPECT quantitative image accuracy and quality assurance for use with nonstandard radionuclides, especially with longer half-lives, in clinical imaging trials. Methods: Procedures have been developed for quantitative PET and SPECT image calibration for use in clinical trials. The protocol uses a 3-step approach: check quantitative accuracy with a previously calibrated radionuclide in a simple geometry, check the novel trial radionuclide in the same geometry, and check the novel radionuclide in a more challenging, complex geometry (the National Electrical Manufacturers Association [NEMA] NU-2 International Electrotechnical Commission [IEC] image-quality phantom). The radionuclides used in the trial as an example are 124I (PET) and 131I (SPECT). In both cases, whole-body tomographic SPECT and PET imaging with accompanying low-dose CT are required. PET accuracy is based on calibrating the dose calibrator to produce quantitative images for radionuclides other than 18F, with all images reconstructed on each individual site's PET systems. For SPECT, an independent sensitivity measurement is made and then used to calibrate the SPECT images reconstructed at the core laboratory. After calibration, the final testing for both PET and SPECT uses the NEMA NU-2 IEC image-quality phantom to derive several metrics including quantitative accuracy based on an average SUV (SUVavg). Results: Using the method described, 7 sites in Australia have been qualified for 10 PET/CT scanners using 124I imaging and 8 SPECT/CT systems for 131I. One PET/CT system was found to give a result outside the specification of an SUVavg of 1.0 ± 0.05. All SPECT/CT systems gave an SUVavg accurate to within ±10% (SUVmean, 1.0 ± 0.1) of the true value for reconstructed radioactivity concentration in Bq/cm3 Conclusion: A general methodology has been developed to calibrate and validate PET and SPECT systems for quantitative imaging in clinical trials. The preparation of the test objects and the procedures is relatively simple and can generally be implemented by the staff at the site of the imaging center with the equipment supplied by the clinical trials organization.

Optical properties of barium borate crystal in the THz range revisited.

Low-temperature phase (β-form) barium borate (BBO) is one of the most important nonlinear crystals that has been widely used for optical second-harmonic generation (SHG), especially with femtosecond sources. There was growing interest in its applications in the direct generation of terahertz (THz) radiations, but it was hindered by the lack of knowledge of its basic properties in the THz range. In a recent study based on first-principles quantum chemistry calculation, we found that the theoretically calculated refractive indices of β-BBO in the THz frequency range do not agree with the previously reported values. To explore the discrepancy between measured and calculated results, we grew and cut β-BBO crystals and performed independent experimental measurements on the refractive indices of BBO crystals. The new data show that the order of ordinary and extraordinary index of β-BBO in the THz range is opposite, contrary to several papers previously reported. Based on the newly acquired material properties, simple geometries fulfilling phase matching (PM) conditions with n o(THz)=n o g r(800nm) for efficient generation of THz radiation through optical rectification in β-BBO are proposed.

Plasmonic resonances of metallic moiré superlattices in the infrared range.

The recent surge of interest in moiré photonics arises from the possibility of exploring many groundbreaking physical phenomena in photonics. These phenomena include photonic topological states and magic-angle lasing, which offer an attractive platform for manipulating the flow and confinement of light from remarkably simple device geometries. In this work, we fabricate a series of metallic moiré superlattices supporting moiré plasmon polaritons and explore the moiré-potential induced plasmonic resonances. We demonstrate that two-dimensional moiré plasmonic superlattices exhibit transmittance and polarization-dependent responses because of the localized plasmonic resonances in the infrared range, whose modes have a near-flat dispersion band. Our findings hold the potential for the understanding of localized plasmonic resonances within moiré superlattices.

Aerodynamic Coefficients of a Cube in Hypersonic Flow for All Attitudes

During reentry, spacecraft components are often modeled by simple geometries such as cubes, prisms, and cylinders, and their aerodynamics have been shown to vary with angle of attack. This work investigates the aerodynamics of a cube in Mach 6 flow for all flight attitudes as an example of a generic space debris geometry. Forces and moments acting on the cube are calculated using computational fluid dynamics at 16 orientations, which are chosen to exploit symmetry. The data is then extended to 218 independent orientations, covering all possible incident flow angles. Correlations from spherical harmonic basis functions, selected using sparse regression, are then developed for the force and moment coefficients. Regression errors are small relative to previous studies, demonstrating that spherical harmonics model the coefficients efficiently. We calculate maximum regression errors of up to 1% and 12% of the maximum force and moment coefficient, respectively, compared to 15% and 27% of the maximum force and moment coefficient presented in prior work. The correlations compared well to results from Mach 6 free-flight experiments conducted in the The University of Southern Queensland’s hypersonic wind tunnel, TUSQ. The correlations also compared well to published results from Mach 7 free-flight experiments conducted in the German Aerospace Center’s (DLR) Hypersonic Wind Tunnel, H2K.

Limiting and optimal Strouhal numbers or tip speed ratios for cruising propulsion by fins, flukes, wings and propellers.

Swimming and flying animals produce thrust with oscillating fins, flukes or wings. The relationship between frequency f, amplitude A and forward velocity U can be described with a Strouhal number St, where St = 2fA/U, where animals are observed to cruise with [Formula: see text]-0.4. Under these conditions, thrust is produced economically and a reverse von Kármán wake is observed. However, propeller-driven craft produce thrust with steadily revolving blades and a helical wake. Here, the simplified aerodynamic geometry of lift-based thrust production is described, applicable to both oscillating and revolving foils. The same geometric principles apply in both cases: if the foil moves too slowly, it cannot produce thrust; if it moves too fast, it produces thrust with excessive power demand. Effective, economic thrust production by animals is not the result of oscillating foils or cyclic vortex shedding; rather, the selection of amplitude and frequency, and wake vortex structure, are corollaries of driving an efficient foil velocity with finite amplitudes. Observed Strouhal numbers for cruising animals appear too low for optimal mechanical efficiency; however, the deviation from optimal efficiency may be small, and there are physical and physiological advantages to relatively low amplitudes and frequencies for swimming and flapping flight.

Charge-induced deformation of scanning electrolyte before contact.

The recent developments in scanning electrochemical probe techniques focus on the strategy of scanning the electrolyte. For example, scanning electrochemical cell microscopy (SECCM) is based on holding the electrolyte in a glass capillary, while scanning gel electrochemical microscopy (SGECM) immobilizes the gel electrolyte on micro-disk electrodes or etched metal wires. In both SECCM and SGECM, the first and essential step is to bring the electrolyte probe into contact with the sample, which is very often achieved by current feedback with a constant applied potential between the probe and the sample. This work attempts to theoretically analyse the deformation of the electrolyte during this approaching process. For a liquid electrolyte in SECCM, surface tension is considered to counterbalance the gravity and electrostatic force in 2D cylindrical coordinates with axial symmetry. The deformation at equilibrium is solved under certain conditions. For a gel electrolyte, a viscoelastic gel is analysed with a simplified 1D geometry. Both equilibrium and dynamic approaching are considered. The results suggest that for both liquid and gel electrolytes, critical conditions exist for breaking the equilibrium. When the applied potential is higher or the distance is lower than the threshold, the force will not equilibrate and the electrolyte will deform until contact. The critical condition depends on the properties (surface tension for a liquid, elastic and viscous moduli for a gel) and geometry (radius of the capillary for a liquid, thickness for a gel) of the electrolyte. Prospects of further extending the work closer to real experimental scenarios, especially SGECM, are also discussed.

Variational Method for Vibration Analysis of Elliptic Cylinders Reinforced with Functionally Graded Carbon Nanotubes.

This study introduces a novel analytical framework for investigating the vibration characteristics of functionally graded carbon nanotube-reinforced composite (FG-CNTRC) elliptical cylindrical shells under arbitrary boundary conditions. Unlike previous studies that focused on simplified geometries or specific boundary conditions, this work combines the least-squares weighted residual method (LSWRM) with an adapted variational principle, addressing high-order vibration errors and ensuring continuity across structural segments. The material properties are modeled using an extended rule of mixtures, capturing the effects of carbon nanotube volume fractions and distribution types on structural dynamics. Additionally, virtual boundary techniques are employed to generalize elastic boundary conditions, enabling the analysis of complex boundary-constrained structures. Numerical validation against existing methods confirms the high accuracy of the proposed framework. Furthermore, the influence of geometric parameters, material characteristics, and boundary stiffness on vibration behavior is comprehensively explored, offering a robust and versatile tool for designing advanced FG-CNTRC structures. This innovative approach provides significant insights into the optimization of nanoscale reinforced composites, making it a valuable reference for engineers and researchers in aerospace, marine, and construction industries.

Effect of geometry on clasp retention force: a finite element analysis study

PurposeThe retention force of a realistic clasp is influenced by multiple, interrelated factors, which complicates the identification of the fundamental relationship between clasp geometry and retention force. While realistic clasps exhibit various shapes, they share basic geometric elements such as length, diameter, and curvature. Simpler geometries are often more conducive to identifying the underlying issues. The aim is to investigate the relationship between clasp geometry and retention force using finite element analysis.MethodsA three-dimensional clasp model was created in ANSYS 19.0 (ANSYS, USA). Two types of models were analyzed: rod-shaped clasps with varying lengths (1–15 mm) and diameters (0.6–1.6 mm), and bending clasps with different base widths (6–12 mm) and heights (0.5–5 mm), all made from cobalt-chromium alloys. For the rod models, stress and retention force were assessed by applying displacement loads and analyzing data with nonlinear regression. For the bending models, a similar analysis was conducted for varying base widths and heights.ResultsMaximum stress consistently concentrated at the clasp base. In rod models, retention force decreased with the third power of length and increased with the fourth power of diameter. For bent specimens, the retention force was approximately inversely proportional to the cube of the base width and inversely proportional to the first power of the height.ConclusionsFinite element analysis revealed distinct functional relationships between clasp geometry and retention force. Further laboratory validation is required.

Design of magnetic field with high homogeneity for single-turn coil

Abstract Single-turn coil (STC) is a kind of destructive pulsed magnet aiming at ultra high magnetic field. In this study, the simple geometry optimization approach to improve the magnetic field homogeneity of STC is proposed. By making the conductor inner surface concave, the amplitude of the magnetic field is decreased by only 15%, while the space volume of the homogeneous magnetic field is increased by 200%–600%. Through three STC examples with different conductor inner diameters and different discharge currents, the effectiveness of this method is validated. In particular, it is theoretically proven that the volume of the homogeneous magnetic field increases as the inner surface concave curvature radius decreases. This geometry optimization method provides the theoretical support for homogeneous field design of STC.

Real-Time Co-Editing of Geographic Features

Real-time GIS enables multiple geographically dislocated users to collaboratively edit geospatial data. However, being based on the strong consistency model, traditional real-time GIS implementations cannot provide fully automatic conflict resolution. In highly dynamic situations with increased probability for conflicts, this will hinder user experience. Conflict-free replicated data types (CRDTs), a technology based on a more relaxed concurrency control model called strong eventual consistency, can resolve all conflicts in real time, letting the users work on their local copies of the data without any restrictions. The application of CRDTs to real-time geospatial geometry co-editing has, to the best of our knowledge, not been investigated. Within this research, we therefore developed a simple web-based real-time geospatial geometry co-editing system using an existing CRDT implementation in Javascript coupled with OpenLayers. When applied to the co-editing of geospatial geometry in its native form, standard CRDT conflict resolution mechanics exhibit some issues. As an attempt to address these issues, we developed an advanced operation generation technique named “tentative operations”. This technique allows for the operations to be generated over the most recent session-wide state of the data, which in effect highly reduces concurrency and provides “geometry aware” conflict resolution. The tests we conducted using the developed system showed that in low-latency network conditions, the negative effects of standard CRDT conflict resolution mechanics do get minimized even under increased system loads.

FRESH 3D Bioprinting of Collagen Types I, II, and III.

Collagens play a vital role in the mechanical integrity of tissues as well as in physical and chemical signaling throughout the body. As such, collagens are widely used biomaterials in tissue engineering; however, most 3D fabrication methods use only collagen type I and are restricted to simple cast or molded geometries that are not representative of native tissue. Freeform reversible embedding of suspended hydrogel (FRESH) 3D bioprinting has emerged as a method to fabricate complex 3D scaffolds from collagen I but has yet to be leveraged for other collagen isoforms. Here, we developed collagen type II, collagen type III, and combination bioinks for FRESH 3D bioprinting of millimeter-sized scaffolds with micrometer scale features with fidelity comparable to scaffolds fabricated with the established collagen I bioink. At the microscale, single filament extrusions were similar across all collagen bioinks with a nominal diameter of ∼100 μm using a 34-gauge needle. Scaffolds as large as 10 × 10 × 2 mm were also fabricated and showed similar overall resolution and fidelity across collagen bioinks. Finally, cell adhesion and growth on the different collagen bioinks as either cast or FRESH 3D bioprinted scaffolds were compared and found to support similar growth behaviors. In total, our results expand the range of collagen isoform bioinks that can be 3D bioprinted and demonstrate that collagen types I, II, III, and combinations thereof can all be FRESH printed with high fidelity and comparable biological response. This serves to expand the toolkit for the fabrication of tailored collagen scaffolds that can better recapitulate the extracellular matrix properties of specific tissue types.