The active thickness of the translational landslides plays a pivotal role in evaluating its hazards and simulating its instability. Existing techniques have difficulties in estimating the accurate active thickness due to the limitations of observation conditions and imaging geometry, leading to deviations in failure simulations. To overcome these challenges, this study proposes an enhanced method that utilizes multi-orbit Interferometric Synthetic Aperture Radar (InSAR) observations to estimate the active thickness of the translational landslides and subsequently conduct more accurate instability simulations. The method involves integrating multi-orbit InSAR imaging parameters with the spatial geometry of the landslide to establish a slope coordinate system. This system enables the projection of one-dimensional InSAR Line Of Sight (LOS) displacements onto the three-dimensional displacements of the landslide. Subsequently, the active thickness is estimated by combining InSAR three-dimensional displacements with the mass conservation method. Finally, the estimated thickness is incorporated into the geological model construction to simulate the dynamic movement of the landslide. The method was applied to the Xiongba translational landslide in Gongga County, Tibet Autonomous Region, China. The results show that the deformation is mainly concentrated at its forefront, with maximum three-dimensional deformation rates of 4.7 m/a, 2.3 m/a, and 1.24 m/a. The landslide encompasses an estimated area of around 5.33 square kilometers, and its active thickness varies from 0 to 106.59 m. The maximum displacement distance reaches 1469.76 m, with a peak velocity of 60.37 m/s. The proposed method provides scientific support for assessing, analyzing, and preventing landslide disasters.