Implosion may occur when a hollow pressure structure with geometric imperfections works in deep-sea environments. Therefore, the implosion phenomenon and failure mechanisms of a titanium alloy spherical pressure hull are investigated by experiments and developed numerical methods in ultra-high-pressure water conditions. Firstly, the experiments were conducted using a full-ocean-depth sea environment simulator. Then the validity of the numerical analysis were demonstrated by comparing the shock wave of fluid and destroyed fragments of structure. Finally, the characteristics of underwater implosion were examined under different hydrostatic pressures, including the propagation of shock waves, high-speed motion of the compressible flow, nonlinear deformation of the spherical pressure hull, and energy balance and evolution. The results showed that the vertical impact effect occurs during the underwater implosion of a metallic sphere. Moreover, the shock wave emerges earlier and the cracks break into smaller fragments with the increase of hydrostatic pressure. Besides, the smaller volume of the air cavity is compressed and the larger amplitude of potential energy is dropped when the hydrostatic pressure is larger. Meanwhile, the internal energy of air and structure increases, while the internal and kinetic energy of air oscillates slightly due to the pulsation characteristics of the air cavity.