Greenland's peripheral glaciers and ice caps (GICs) contribute significant amounts of meltwater to the oceans but also affect local economies and livelihoods. Here we created multi-temporal geodetic elevation change datasets to compute mass changes for 6149 glaciers around the entire periphery of Greenland. These glaciers have lost a total of at least 276 ± 55 Gt of ice, or 0.76 ± 0.15 mm sea level equivalent, from their ablation areas between 1978 and 2015. If we assume no mass loss within accumulation areas, then the mean mass balance has been at least −0.10 ± 0.02 m w.e. yr−1. In general, west Greenland glaciers have had a more negative mass balance and experienced accelerated mass loss since 2006 (x 2.7 in south west region, x 5.6 in central west region). Conversely, east Greenland glaciers have generally experienced a decrease in the rate of mass loss. Lake-terminating glaciers have experienced the most negative mass balance, exacerbated by the occurrence of debris cover. These findings quantify great spatial heterogeneity, give context to the recent history of mass loss from GICs, and suggest the importance of including local glacier properties within glacier evolution models.