Introduction: The survey of the mollusc fauna (malacofauna) of a geopolitical region (State) is important from several aspects, reaching several important sectors of knowledge. So if all regions could do the same we would have within, a few years, expanded and completed the catalog of molluscs in Brazil, with much still to be added with regard to terrestrial and freshwater fauna. Objective: Updated general rеᴠiеw of the inventory of non-marine molluscs occurring in the Santa Catarina State/ SC, subtropical Central Southern portion of the Brazilian territory. Methodology: Organization of a occurring State species taxonomic checklist and their corresponding reference database, comprising the regional knowledge formally produced around the theme at least since the year 2003. Results and Conclusions: Confirmed and recorded regional total of 241 species (202 Gastropoda & 39 Bivalvia), among which at least 86 (79 Gastropoda & 7 Bivalvia) exhibit radicals synonymical (among others) changes recently reported through the global platform "MolluscaBase" and available literature of recent production, taxonomically included all in 95 genera (83 Gastropoda & 12 Bivalvia) and 40 families (35 Gastropoda & 5 Bivalvia), with aggregated additional information about their known biogeographical distribution in the territorial space of the State.