Abstract Ophiodes Wagler, 1828, is a poorly known legless lizard genus, widely distributed across South America east of the Andes, and composed of five described species and other additional taxa that have not been formally described but are widely referred to in recent publications. After reviewing major herpetological collections in Rio Grande do Sul and conducting fieldwork for more than 2 decades in the Lagoa dos Patos Estuary, we came across a new species of Ophiodes, herein described. The new species is diagnosed from its congeners based on the combination of a dorsum with three wide, dark brown longitudinal stripes and two pairs of conspicuous light yellow stripes, one pair paravertebral and another dorsolateral; dark vertebral line absent; background coloration of sides light gray with four to five pale and narrow longitudinal stripes; ventral region uniformly light gray; hind limb extending to the posterior vent scale margin; small eyes, smaller than half of snout–ocular distance; supralabials wi...