BACKGROUND: Infection is still the most common cause of morbidity and mortality in patients with Diabetes in our country. Many common infections are polymicrobial in Diabetic patients,So heightened sense of awareness about these infections will lead to early diagnosis and subsequent treatment of these potential life threatening infections,for better prognosis and also to avoid high degree of Drug resistance in them. AIM:To study the etiological agent and its responsible for the prevalence of infections in Diabetes mellitus patients. MATERIALS AND METHODS: A Hospital based observational prospective study was conducted in the department of general medicine in santhiram medical college and general hospital for 6 months,50 Diabetic patients attending patient in the department of general medicine and relevant investigations done and assessed the etiological agent responsible for prevalence of infections in diabetes mellitus patients. RESULTS: rd th Out of 50 Patients studied,the majority of the group belonged to the 3 and 4 decade which shows that Diabetes with infections are more prevalent in the middle aged people in this study. Soft tissue infections,being the commonest of the infections contributed,37% of the total patients in the study, followed by respiratory infections 30% , genitourinary infections 20% and a very small group of GI infections 7%. Nervous system infections and infections of blood infections constituted a minority of 3% and 4% respectively. CONCLUSION : rd Infections in diabetes are more in the 3 and 4 th decades. Soft tissue infections, respiratory tract infections, and genitourinary infections are more prevalent in diabetics in that order