AbstractCrops produced using recombinant DNA technology have invaluable food security roles but are not broadly accepted. Food insecurity affects between 45% and 50% of the Ghanaian populace, while the debate to adopt, accept, use, and commercialize genetically modified (GM) crops is ongoing. In this study, a choice‐based conjoint experimental design was adopted to investigate factors driving the acceptance or rejection of GM crops in Ghana. Results from average marginal component effect estimation suggest that safety concern is the major driver for accepting or rejecting GM crops. This was further confirmed using predicted probabilities and marginal means estimation of community acceptance especially when it possesses certain attributes. The safer the GM crop is perceived for human consumption, health, and environment, the more likely the Ghanaian populace will accept it. In addition, yield and taste were observed to be other key driving factors to accept GM crops. Importantly, the country of patency was also observed to be a critical driving factor for whether or not a GM crop is accepted in Ghana. There is a need for active and greater engagement with the Ghanaian populace to put proper legislation, regulations, policies, and knowledge co‐creation process to ensure the proper use of GM crops.