Generic Name Research Articles

ANALYSIS OF DRUG UTILIZATION PATTERN IN CHRONIC KIDNEY DISEASE PATIENTS IN A TERTIARY CARE HOSPITAL, SOUTH INDIA

Objective: The objective of the study is to assess the drug utilization pattern of various drugs prescribed in chronic kidney disease (CKD) patients in a tertiary care hospital. Methods: As a cross-sectional study 200 prescriptions were randomly selected from both the nephrology outpatient department and the inpatient ward. Patient demographics details, CKD staging, classes of drugs prescribed, and number of drugs prescribed were noted and data were analyzed with the World Health Organization core prescribing indicators. Results: Incidence of CKD is more common in the age group of 40–50 years (45%) with male predominance (70%). Hypertension, diabetes, and anemia are the common comorbid conditions seen with CKD. Anti-hypertensives, anti-anemic drugs, calcium supplements, and anti-diabetic drugs are the commonly prescribed drugs in CKD. Number of prescription contains that generic names are near optimal and drugs from the National List of Essential Medicine are optimal. Majority of the prescriptions contain on average 5 drugs. Conclusion: Diabetes and high blood pressure are the two most common causes of CKD with male dominance. Since polypharmacy is common in CKD patients , they should be monitored for drug – drug interaction and adverse drug reactions.

Challenges Associated with Forming Generic Names for Herbal Medicinal Products

INTRODUCTION. The lack of a unified approach to establishing generic (grouping) names, which must be specified for herbal medicinal products, presents a challenge to developers and manufacturers preparing registration dossiers, as well as to regulators reviewing their submissions.AIM. This study aimed to set forth common approaches to establishing generic names for herbal medicinal products based on studying the terminology used in different legal systems.DISCUSSION. The authors analysed the pharmaceutical terminology used for herbal medicinal products at national and supranational levels in the Russian Federation, the Eurasian Economic Union (EAEU), the Republic of Belarus, the European Union (EU), the United Kingdom, and the United States. This analysis revealed differences in the terminology used in the Russian Federation and the EAEU. For example, the definition of “herbal drugs” is more detailed in the EAEU documents than in the Russian documents, and the definitions of “herbal drug preparation” and “herbal medicinal product” are not the same as well. The authors analysed the approaches to generic naming of herbal medicinal products and detected some improperly formed generic names in the regulatory documentation and Russian State Register of Medicinal Products. In addition, the study revealed variability in generic names proposed by different manufacturers for medicinal products having the same trade name. The authors described the selection of generic names for herbal medicinal products, including fatty or essential oils and liquid or dry extracts. The authors touched upon generic naming of some types of source plants when the morphological group of the herbal drug or the name of the source plant is ambiguous, the Latin name and the Russian name of the herbal drug are inconsistent, or the Latin name of the resulting product or the morphological group of the herbal drug is erroneous. The authors systematised and unified approaches to generic naming of herbal medicinal products with due regard to the species of source plants, the morphological groups of herbal drugs, and the production technology and composition of herbal medicinal products. The authors analysed typical errors in establishing conventional and generic names for herbal drugs and herbal medicinal products associated with incorrectly identified morphological groups of herbal drugs, incorrect source plant names, mismatching structures of Latin and Russian names of herbal drugs, erroneous Latin names of the resulting products, or wrongly assigned morphological groups of herbal drugs.CONCLUSIONS. According to the analysis of the names of herbal drugs, herbal drug preparations, and herbal medicinal products used in the State Pharmacopoeia of the Russian Federation (editions XI–XV), the Pharmacopoeia of the EAEU, and the European Pharmacopoeia, the terminology of these legal systems is harmonised to a high degree. The alignment of terminology is the closest between the regulatory documents of the EAEU and the EU. The terms and names used in Russia need further unification. The results of this study can be used in Russian pharmacopoeial practice to develop regulatory documents, prepare registration dossiers, and conduct expert reviews of submissions for herbal medicinal products.

Is Delicata Krammer a validly published genus name? Trying to put light on Article 20.2

SummaryThis paper delves into the intricacies of botanical nomenclature, specifically focusing on the interpretation and application of Art. 20.2 of the International Code of Nomenclature (ICN). It critically analyzes the case of Delicata Krammer, against the backdrop of Art. 20.2. The investigation shows that Delicata does not coincide with any established Latin technical term used in morphology and hence fulfills the ICN requirements, confirming its validity. This finding highlights the need for clearer guidelines in distinguishing descriptive Latin terms from technical terms used in morphology. This paper contributes to the ongoing discourse in botanical taxonomy by advocating for revised practices and interpretations of nomenclatural rules, ensuring stability and precision in the naming of taxa.

Proposal of Shuttleworthella gen. nov. and Nostocoides gen. nov. as replacement names for the illegitimate prokaryotic generic names Shuttleworthia and Tetrasphaera, respectively.

The prokaryotic generic name Shuttleworthia Downes et al. 2002 is illegitimate because it is a later homonym of the plant genus Shuttleworthia Meisner 1840 and the mollusk genus Shuttleworthia Baker 1941 (Principle 2 and Rule 51b(5) of the International Code of Nomenclature of Prokaryotes). We therefore propose the replacement generic name Shuttleworthella, with type species Shuttleworthella satelles comb. nov. The prokaryotic generic name Tetrasphaera Maszenan et al. 2000 is illegitimate because it is a later homonym of Tetrasphaera Popofsky 1913 (Protozoa, Radiolaria) and of Tetrasphaera Górka 1965 (a fossil dinoflagellate) (Rule 51b(4) of the International Code of Nomenclature of Prokaryotes). We therefore propose the replacement generic name Nostocoides, with type species Nostocoides japonicum comb. nov.

Conformity of Package Inserts Information to Regulatory Requirements

ABSTRACT Background: Accurate and reliable information regarding drugs is essential for safe and effective use of drugs. It is not possible for the clinician to refer research articles every time for complete updates. In such situations, package inserts (PIs) form an authentic information for the doctor and patient. The study was intended to assess the information completeness and precision of PIs using the criteria laid down by, sections 6.2 and 6.3 of Schedule D (II), Schedule Y of Drugs and Cosmetic Act (1940) and Rules (1945). Materials and Methods: PIs of different formulations were collected from various departments, and also local and regional chemists. The information adequacy was done by 25 checklist proposed by the Indian Drug and Cosmetic Act (1940) and Rules, 1945 under sections 6.2 and 6.3 of Schedule D and Schedule Y. A score of “1” was given, if information was present, and “0” if there was no information. Information adequacy scores also calculated. Results: A total of 207 PIs were analyzed. Majority of PIs belong Grade B category of drug information (174). Generic name, composition, posology and method of administration, undesirable effects, contraindications, drug interactions, special precautions, legibility, storage and contraindications during pregnancy and breast feeding were mentioned by nearly all. Gaps were observed in handling instructions, influence on person’s self-driving and machinery operation capabilities, pharmaceutical incompatibilities, shelf life, excipients and Pharmacokinetic and dynamic information not updated regularly. Conclusion: The current study shows that there is still inadequacy of particulars regarding drug information. Hence, it is essential to establish proper uniform standards for the currently available PIs. An absolute and flawless PI should provide complete information. This requires continuous and constant effort from manufacturer and regulatory authorities to promote safe and rational use of medicines.

School shooting: are psychiatrists capable of preventing tragedies?

Armed attacks with numerous victims committed in educational institutions of various levels, mainly (but not always) with the use of firearms, have received the generic name “school shooting”, and attackers are most often called “school shooters”. The United States is the leader in the prevalence of mass murders in educational institutions, although these tragic incidents also occur in other countries, and their number shows a tendency to constantly increase. Since any murder is an abnormal phenomenon, the question of the mental health of school shooters naturally arises. Research shows that not all assailants show symptoms of mental disorders; the most common cause of armed attacks is bullying and the desire to take revenge on offenders for cruel humiliation. In cases where a mental disorder is still diagnosed, not all students, as well as their family members, agree to receive psychiatric care. The prevention of armed attacks must be carried out by the efforts of school counsellors and school psychologists with the possible involvement of psychiatrists, although the potential of psychiatric care in the prevention of school murders, according to the authors of the article, is quite limited.

A new generic name for the “Lepadichthys” lineatus complex with a rediagnosis of Discotrema, a senior synonym of Unguitrema, and comments on their phylogenetic relationships (Gobiesocidae: Diademichthyinae)

Abstract Rhinolepadichthys, a new genus of the gobiesocid subfamily Diademichthyinae, is described for the “Lepadichthys” lineatus complex (including Rhinolepadichthys geminuscomb. nov., R. heemstraorumcomb. nov., R. lineatuscomb. nov., and R. polyastrouscomb. nov.). Detailed investigation of external morphology and osteological anatomy of the new genus and related genera suggests that Rhinolepadichthys represents the sister genus to Discotrema, based on the following putative synapomorphies: (1) presence of a hardened (potentially keratinized) cap on the surface of at least some disc papillae (vs. surface of disc papillae soft, without hardened cap); and (2) the anterolateral part of the ventral postcleithrum extended anteriorly as a well-developed rod-like process, its tip close to the base of pelvic-fin soft ray 4 (vs. only weakly pointed, or irregular). Compared with Discotrema, Rhinolepadichthysgen. nov. is distinguished by the presence of a row of 8–12 large papillae on the inner surface of the upper and lower lips (vs. inner surface of lips smooth, without distinct papillae); the absence (vs. presence) of a well-developed lateral process on the pterotic immediately posterior to the opening of the otic canal; the presence (vs. absence) of gill rakers on the anterior edge of ceratobranchials 1–3; the presence (vs. absence) of gill rakers on the posterior edge of ceratobranchial 4; having the upper pharyngeal teeth arranged in a loose patch on the ventral surface of the pharyngobranchial 3 toothplate, with tooth tips directed posteroventrally (vs. arranged in a single row along posteroventral edge of the pharyngobranchial 3 toothplate, with tooth tips directed posteriorly); features of the adhesive disc, including outline of disc papillae roughly hexagonal or ovoid and with a flattened surface (vs. outline circular, at least some with raised, dome-like surface); the absence (vs. presence) of a deep cavity at the center of disc region C; the absence (vs. presence) of three paired and one median cluster of small papillae (reminiscent of bunches of grapes) across the surface of the adhesive disc; and having the ventral postcleithrum entire, not divided into two separate, articulating elements (vs. ventral postcleithrum divided into an anterior and posterior element, separated via a specialized joint). Reexamination of materials of the poorly known genus Unguitrema, considered a close relative of Discotrema, revealed no morphological differences between the two genera. Unguitrema therefore represents a junior synonym of Discotrema.

New insights into the stipitate hydnoid fungi Sarcodon, Hydnellum, and the formerly informally defined Neosarcodon, with emphasis on the edible species marketed in Southwest China

Sarcodon and Hydnellum are two ectomycorrhizal genera of important ecological and economic value in Southwest China, and they are common in the free markets in this region. It was estimated that more than 1,500 tonnes of them were sold as edible per year, but there was little information about the taxonomic placements of these edible mushrooms sold in the markets. Traditional concepts of the two genera have also been challenged recently, and circumscription of Sarcodon and the informally defined clade “Neosarcodon” remained unresolved. In the present study, specimens collected in the field and purchased from the markets in Southwest China were analyzed based on morphological characters and DNA sequences. Phylogeny of the traditional Sarcodon s. lat. and Hydnellum s. lat. was reconstructed from the combined internal transcribed spacer (ITS), nuclear large ribosomal subunit (nLSU) and RNA polymerase II second largest subunit (RPB2) dataset based on expanded samples to reevaluate the taxonomic placements of the two genera. In the present molecular analyses, four distinct clades were recovered and strongly supported: Hydnellum, Neosarcodon, Phellodon and Sarcodon. Neosarcodon is formally introduced as a generic name to include nine species previously placed in Sarcodon, and the delimitation of Sarcodon is revised based on phylogenetic and morphological studies. Phylogenetic analyses also revealed an unexpected species diversity (17 phylogenetic species) of Sarcodon and Hydnellum in the markets; nine phylogenetic species of Sarcodon and eight of Hydnellum were uncovered from the samples collected in the markets. Eight species were resolved in the traditional S. imbricatus complex, with S. imbricatus s.str. being the most common edible stipitate hydnoid fungal species. Three of the edible Hydnellum species (H. edulium, H. subalpinum, and H. subscabrosellum), and five separated from the S. imbricatus complex (Sarcodon flavidus, S. giganteus, S. neosquamosus, S. nigrosquamosus, and S. pseudoimbricatus), are described as new. Three new Chinese records (H. illudens, H. martioflavum, and H. versipelle), and the notable S. imbricatus and S. leucopus are also reported.

Prescribing patterns and analyzing the usage of corticosteroid therapy at tertiary care hospital

Corticosteroids are used extensively in treating inflammation. They provide short-term symptomatic relief in abnormalities of conditions like Auto immune diseases, Dermatological and Respiratory diseases. Adverse effects of Corticosteroids include Cushing’s syndrome, Skin atrophy, contact dermatitis, tachyphylaxis, Myelosuppression, Diabetes mellitus, Hypertension, pleural effusion. As per the sources available from the regulatory authority of Central Drugs Standard Control organization, inappropriate use of Corticosteroids is more commonly practiced in India almost all the drugs are prescribed rationally. The Pharmacist can promote better patient care and drug safety. Most of the Physician is recommending the drugs are mostly branded names. Our study suggests provide it in generic names. Clinical Pharmacists in associations with clinicians must play a crucial role in minimizing the problems associated with irrational usage of corticosteriods.

Commonly prescribed medicines, core prescribing indicators, and prescription errors in a tertiary healthcare setting in Sri Lanka: a descriptive cross-sectional study

Abstract Objectives To describe the commonly prescribed medicines, WHO/INRUD core prescribing indicators, and prescription errors from a tertiary healthcare setting in Sri Lanka. Methods This study was conducted at clinics and wards in a group of tertiary hospitals from Colombo, Sri Lanka. A total of 1600 prescriptions (800 in-ward [IW] and 800 out-patient clinic [OP]) were analysed and evaluated against WHO/INRUD core prescribing indicators. Prescription errors and medication interactions were also analysed. Key findings Number of medicines per encounter on average was 4.2 ± 2.9 (median: 4.0; range: 1–18) (IW vs. OP: 5.0 ± 3.1 vs. 3.4 ± 2.1; P < 0.001). Overall, the percentage of prescriptions with an antibiotic was 25.9% (n = 415) (IW vs. OP: 45.0% vs. 6.9%, P < 0.001). Percentage of encounters with an injection was 20.4% (n = 326) (IW vs. OP: 36.9% vs. 3.9%, P < 0.001) and percentage of medicine prescribed by generic name was 90.7% (IW 92.9% vs. OP 87.3%, P < 0.001). Prescribing from the essential medicines list (EML) was 76.9% (IW 77.7% vs. OP 75.7%, P-NS). Among IW prescriptions details regarding allergies were not mentioned in 643 (80.4%), while in paediatric prescriptions weight was not specified in 242 (75.6%). At least a single abbreviation was used in 638 prescriptions (39.9%). One or more medication interactions were identified in 744 (46.5%) prescriptions (major: 86 [5.4%]). Conclusions We identified a relatively high number of average medicines per encounter, indicating a degree of polypharmacy. In addition, generic prescribing and usage of EML medicines are areas recommended for further improvement. Prescription errors were common, and several commission/omission errors had potential for preventable patient harm.

Molecular phylogenetics of the trochid subfamily Umboniinae (Gastropoda: Trochoidea): working towards a new systematic framework

ABSTRACT We present here the most taxon-rich phylogeny for the trochid subfamily Umboniinae published to date, with representatives from 14 of the 19 known genera, and as a result show that Umboniinae needs comprehensive taxonomic and systematic revision. We identified one clade corresponding to a new genus with four species collected from deeper water than is typical of most umboniine taxa and one new species likely belonging to a second, undescribed genus (all to be described elsewhere). Only four genera, as currently interpreted were recovered, as monophyletic: Umbonium, Lirularia, Monilea and Rossiteria. Zethalia (monotypic for extant taxa), Pseudominolia, Isanda and Parminolia were all represented by a single species (the latter by Gibbula vanwalleghemi; Poppe, Tagaro & Dekker, 2006). Conotalopia, Ethalia, Ethaliella, Ethminolia, Sericominolia and Vanitrochus were all polyphyletic. We formally recognize the following new combinations: Sericominolia glaphyrella (Melvill & Standen, 1895), Sericominolia vitiliginea (Menke, 1843), Vanitrochus ornatus (Sowerby III, 1903) and Parminolia vanwalleghemi (Poppe, Tagaro & Dekker, 2006), although further molecular studies are desirable to confirm these decisions. The first three generic reassignments make Sericominolia and Vanitrochus monophyletic in our tree. We also suggest that Ethaliella cf. rhodomphala (Souverbie, 1875) should be transferred to one of several clades with species previously assigned to Ethminolia, for which an appropriate genus name has not yet been resolved. This decision makes Ethaliella monophyletic. We also identified several cryptic species complexes, including Rossiteria nucleus (Philippi, 1850), the type species of Rossiteria. The phylogeny presented is a first step towards a more resolved systematic framework for Umboniinae and will allow future studies of key morphological innovations.

Co-production and the Use of Constituency Development Funds (CDFs) in Poverty Alleviation: A Case of Selected Constituencies in Zambia

Constituency Development Fund (CDF) is the generic name for a policy tool that dedicates public money to benefit specific political subdivisions through allocations and/or spending decisions influenced by their representatives in the national parliament (Centre for International Development 2009: 8-9). Dissimilar to large national development projects, CDF-financed projects are essentially community based and driven with the major aim of bringing facilities and services closer to people for purposes of improving their social economic living conditions, especially reducing poverty. In the 2022 Zambia National Budget, CDF saw an unprecedented increase in the size of funding and scope of its mandate. For the year 2023, CDF was increased from K25.7 million (USD 1,070,833) to K28.3 million (USD 1,179,167) per constituency while being expanded to include additional components such as youth, disabled and women empowerment programs as well as secondary school bursaries that will now be locally administered. It is in this regard that the authors undertook a study to assess the impact of CDFs on poverty alleviation in 12 constituencies selected namely, Kankoyo, Moomba, Bweengwa, Mpika, Rufunsa, Monze, Chawama, Mufulira, Kaoma, Kantanshi, Mbala and Solwezi. Data was collected from men, youth and the disabled from the said constituencies. Due to the nature of data collected, mixed methodology research was used. Qualitative data was analysed with the aid of ATLAS.ti while quantitative data was analysed using SPSS Version 30. Key findings are that the general public is aware of the existence of the CDFs and that it is a government empowerment programme especially for funding education and skills acquisition through school bursaries and skills development components, community projects and empowerment loans. However, empirical evidence on the ground point to challenges of the CDFs through political patronage, nepotism, the abdication of key decision making to the politician (Member of parliament) who has massive influence as he/she has power to arbitrary hand-pick 6 members out of 12 to the main CDF committee responsible for administration of CDF funds.

The genus Fomitopsis (Polyporales, Basidiomycota) reconsidered.

Based on seven- and three-gene datasets, we discuss four alternative approaches for a reclassification of Fomitopsidaceae (Polyporales, Basidiomycota). After taking into account morphological diversity in the family, we argue in favour of distinguishing three genera only, viz. Anthoporia, Antrodia andFomitopsis. Fomitopsis becomes a large genus with 128 accepted species, containing almost all former Fomitopsis spp. and most species formerly placed in Antrodia, Daedalea and Laccocephalum. Genera Buglossoporus, Cartilosoma, Daedalea, Melanoporia, Neolentiporus, alongside twenty others, are treated as synonyms of Fomitopsis. This generic scheme allows for morphologically distinct genera in Fomitopsidaceae, unlike other schemes we considered. We provide arguments for retaining Fomitopsis and suppressing earlier (Daedalea, Caloporus) or simultaneously published generic names (Piptoporus) considered here as its synonyms. Taxonomy of nine species complexes in the genus is revised based on ITS, ITS +TEF1, ITS +TEF1 +RPB1 and ITS +TEF1 +RPB2 datasets. In total, 17 species are described as new to science, 26 older species are reinstated and 26 currently accepted species names are relegated to synonymy. A condensed identification key for all accepted species in the genus is provided.

200 years of taxonomic confusion: Sporendonema and allies

The genus Sporendonema (Gymnoascaceae, Onygenales) was introduced in 1827 with the type species S. casei for a red mould on cheese. Cheese is a consistent niche for this species. Sphaerosporium equinum is another species classified in Gymnoascaceae and has also been reported from cheese. Recently, other habitats have been reported for both Sporendonema casei and Sphaerosporium equinum. The present study aimed to investigate the taxonomy of Sporendonema and Sphaerosporium, as well as a close neighbour, Arachniotus. Two strains of Hormiscium aurantiacum, another related cheese-associated species were also included in the analyses. Strains were evaluated in terms of macro- and micromorphology, physiology including salt tolerance, growth rate at different temperatures, casein degradation, cellulase activity, lipolytic activity, and multi-locus phylogeny with sequences of the nuclear ribosomal internal transcribed spacer region, the D1-D2 region of the large subunit and partial β-tubulin locus sequences. The results showed that the analysed species were congeneric, and the generic names Arachniotus and Sphaerosporium should be reduced to the synonymy of Sporendonema. Therefore, four new combinations as well as one lectotype and one epitype were designated in Sporendonema. Two strains attributed to Sphaerosporium equinum from substrates other than cheese were found to be phylogenetically and morphologically deviant and were introduced as a new species named Sporendonema isthmoides.

Skogea, a replacement name for Actinostephanus F. Wen, Y. G. Wei, and L. F. Fu (Gesneriaceae: Didymocarpoidae)

AbstractA replacement generic name, Skogea U. B. Deshmukh, is proposed for the name of the recently described genus Actinostephanus F. Wen, Y. G. Wei, and L. F. Fu (Gesneriaceae: Didymocarpoidae) segregated from Boeica C.B. Clarke, Rhynchotechum Blume, and Leptoboea Benth. because the name Actinostephanus has been recommended to be treated as a later homonym of Actinostephanos Khursevich (Bacillariophyta) by the nomenclature committee for algae.

Retrospective review of medicine utilization for noncommunicable diseases in three public sector pharmacies in Jamaica.

The rational use of medicines offers a cost-saving strategy to maximize therapeutic outcomes for developing and developed countries. The aim of this study was to evaluate the rational use of medicines for selected noncommunicable diseases (NCDs) at three pharmacies at public hospitals in Jamaica using the World Health Organization's (WHO's) prescribing indicators. In this retrospective cross-sectional study, prescriptions for adult outpatients containing at least one medicine for cardiovascular disease, diabetes, cancer, chronic obstructive pulmonary disease or asthma that were filled between January and July 2019 were reviewed using WHO's prescribing indicators for the rational use of medicines. Data were analyzed and expressed as descriptive and inferential statistics. For all analyses conducted, significance was determined at P < 0.05. A total of 1 500 prescriptions covering 5 979 medicines were reviewed; prescriptions were mostly written for female patients aged 42-60 years. Polypharmacy was observed in 35.6% (534) of prescriptions, and there was an average of 4 medicines per prescription, with a maximum of 17. Most of the prescriptions at each site were filled, with the main reason for not dispensing a medicine being that it was out of stock. Generic prescribing was high for all sites, accounting for more than 95% (5 722) of prescribed medicines. There was full compliance with prescribing according to the WHO Model List of Essential Medicines at two of the sites, but it was just off the target at Site 1, by 1.4%. The WHO guidelines for the rational use of medicines were followed with respect to the proportion of medicines prescribed from the WHO Model List and the proportion of antibiotics prescribed. The number of medicines per prescription and the proportion of medicines prescribed by generic name did not meet the WHO criteria. However, prescribing was aligned with treatment guidelines for the selected NCDs.

Long-Term Monitoring of the Traditional Knowledge of Plant Species Used for Culinary Purposes in the Valencia Region, South-Eastern Spain.

The aim of this study is to inventory and study ethnobotanical knowledge of edible plants in the Valencian Community (Spain). In respect to culinary uses, 92 species of plant were reported to be edible, finding the following uses: 58 raw, 52 cooked, 16 fried, 7 dried, 21 in liquors and beverages, 25 in dessert and sweets, 11 as seasoning, 17 in pickles, and 10 to curdle milk. We prepared a database that includes genus, family, scientific, and vernacular names in Spanish and Catalan for each plant. We also created a classification of nine edible uses and plant parts used, being Asteraceae (n = 18), Brassicaceae (n = 7), Chenopodiaceae (n = 6), and Rosaceae (n = 6) the families most characterized for gastronomic purposes. The species with the most elevated cultural importance (CI) values were Foeniculum vulgare (CI = 1.389), Cynara scolymus (CI = 1.374), Papaver rhoeas (CI = 1.211), Beta vulgaris (CI = 1.167), and Juglans regia (CI = 1.155). The most used parts were the leaves (71), flowers (25), and branches (19), while the least used were roots (9) and seeds (8). Traditional knowledge of these plants helps to preserve traditional cuisine, promote the local economy and, in several species, encourage their cultivation.

Antibiotic Dispensing Practice among Medicine Retailers of Butwal and Bhairahawa Cities: An Interventional Study

Background:: Dispensing practice is the fundamental component of the rational use of drugs. Inappropriate dispensing of drugs can lead to Adverse drug reaction (ADR), Drug interaction (DI), therapeutic failure, and increased cost of treatment. In case of antibiotic misuse, it can lead to developing an extra burden of antibiotic resistance. Objective:: The objective of this study is to determine the antibiotic dispensing practice and the impact of intervention among medicine retailers of Butwal and Bhairahawa cities of Nepal. Methods:: An interventional simulated patients survey study was conducted in two cities of Nepal from 2016-2018. A scenario of fictitious cases of common cold and running nose was simulated by two trained pharmacists in two different sites. Prior to the survey, the researcher visited selected retailers to obtain consent and demography details. About two weeks after obtaining consent, simulated patients visited the retailers. The information given by the community pharmacist was memorized and recorded in data collection form after leaving the community pharmacy. The intervention study was carried out 30 days after the simulated study survey. The educational intervention was given to the test group i.e. the community medicine retailer of Butwal. The researchers also provided a booklet to the test groups. Post-intervention simulated patient survey was conducted after 3 days of the training period. Data were entered into Microsoft Excel and SPSS for analysis. Results:: All together 64 community pharmacies were included in this study involving 32 medicine retailers from each city of Butwal and Bhairahawa. The total drugs dispensed by medicine retailers were 146 and 127 drugs in Butwal and Bhairahawa, respectively in the before-intervention studies. Similarly, about 122 and 152 drugs were dispensed by medicine retailers in Butwal and Bhairahawa after intervention studies. The average number of medicines dispensed by medicine retailers was 4.56±1.66 and 3.96±1.92 before intervention in the Butwal and Bhairahawa study sites. The average numbers of medicines dispensed by medicine retailers were 3.78±1.06 and 4.78±1.73 after intervention in the study sites of Butwal and Bhairahawa. None of the medicine retailers talked about either the brand or generic name and strength of antibiotic medicine to the simulated patient before and after intervention in both study sites. Similarly, medicine retailers informed about the frequency of dosage of antibiotic medicine to simulated patients before and after interventions in Butwal and Bhairahawa cities. However, there was no statistical significance (P=0.388) observed in Butwal City, whereas in Bhairahawa City, statistical significance (P=0.006) was observed. Conclusion:: Antibiotic dispensing without a prescription is routine. Insufficient medicine information was given to the simulated patient by the medicine retailer. Hence, we suggest meaningful implementation of policy and regular inspection to improve the situation.

Prevalence of Antibiotic Prescription in Primary Healthcare Settings in the Municipality of Prishtina, Kosovo

Background: Antibiotics remain among the most prescribed drugs in primary healthcare, contributing to increased antibiotic resistance in the community and prevailing as an emerging global health concern. We aimed to quantify the prevalence and quality of antibiotic prescription in primary healthcare settings in the Municipality of Prishtina to identify targets for quality improvement.Methods and Results: This study represents a population-based, retrospective cohort, including data from eight randomly selected family medical centers in the Municipality of Prishtina. Each 150th patient on medical records was assessed for demographic data, diagnosis (ICD-10), antibiotic prescription, antibiotic class, and antibiotic form. In total, the study included 1614 cases reviewed. The antibiotic prescription rate was 16%. The health condition for which most of the cases received antibiotics was J18 - Pneumonia, unspecified organism (67%), followed by J03 - Acute tonsillitis (54%), J42 - Unspecified chronic bronchitis (46%), and N39 - Other disorders of the urinary system (43%) Broad-spectrum antibiotics, such as co-amoxiclav (17.7%), amoxicillin (16.5%), and ceftriaxone (12.6%), featured among the most routinely prescribed antibiotics. The antibiotic prescription rate was the highest for cases in the 3-5 age group, of whom 27% received an antibiotic prescription. In 73% of cases, oral antibiotics were prescribed, 69% of which belong to the WHO AWaRe (Access, Watch, Reserve) essential medicines list. Only 18% of antibiotics were prescribed with their generic names. Conclusion: The prevalence of antibiotic prescription in primary healthcare settings in Prishtina is moderately low. These data cannot be extrapolated to other municipalities in Kosovo or other countries due to different organizational levels. High antibiotic prescription rates for young age groups, prescription of broad-spectrum antibiotics, and high rates of parenteral antibiotics were identified as targets for quality improvement.

Drugs associated with a risk of supraventricular tachycardia: analysis using the OpenVigil database.

The OpenVigil database can be used to assess medications that may cause supraventricular tachycardia (SVT) and to produce a reference for their safe use in clinical settings. We analyzed first-quarter data from 2004 to 2023, obtained by searching the OpenVigil database using the keyword "supraventricular tachycardia." Trade names and generic names were obtained by querying the RxNav database, and the proportions were summarized. The proportionate reporting ratio (PRR), reporting odds ratio, and chi-square values were also summarized. We created Asahi diagrams and set the screening criteria to drug events ≥30, PRR >2, and chi-square >4. Outcomes were evaluated using the Side Effect Resource database, several scientific literature databases, and the Hangzhou Yiyao Rational Medication System. A total of 2435 distinct medications were found to induce SVT between the first quarter of 2004 and 2023, leading to 22,375 documented adverse events related to SVT. Further investigation revealed that salbutamol, paroxetine, formoterol, paclitaxel, venlafaxine, and theophylline were most likely to cause SVT. We conducted signal mining of adverse drug events using the OpenVigil database and evaluated the six drugs most likely to cause SVT. The results of this research can serve as a drug safety reference in the clinic.