The outstanding performance of deep neural networks (DNNs) in multiple computer vision in recent years has promoted its widespread use in aerial image semantic segmentation. Nonetheless, prior research has demonstrated the high susceptibility of DNNs to adversarial attacks. This poses significant security risks when applying DNNs to safety-critical earth observation missions. As an essential means of attacking DNNs, data poisoning attacks destroy model performance by contaminating model training data, allowing attackers to control prediction results by carefully crafting poisoning samples. Toward building a more robust DNNs-based aerial image semantic segmentation model, in this study, we proposed a robust invariant feature enhancement network (RIFENet) that can resist data poisoning attacks and has superior semantic segmentation performance. The constructed RIFENet improves the resistance to poisoning attacks by extracting and enhancing robust invariant features. Specifically, RIFENet uses a texture feature enhancement module (T-FEM), structural feature enhancement module (S-FEM), global feature enhancement module (G-FEM), and multi-resolution feature fusion module (MR-FFM) to enhance the representation of different robust features in the feature extraction process to suppress the interference of poisoning samples. Experiments on several benchmark aerial image datasets demonstrate that the proposed method is more robust and exhibits better generalization than other state-of-the-art methods.