This work presents a quantum theory of the nonlinear optical process of second-harmonic generation (SHG) in one-dimensional microresonators. More specifically, we show how the manipulation of vacuum field fluctuations in high-confinement systems, leading to a spectrally (and spatially) modulated commutation relation for the photon's generalized formulations of their creation and annihilation operators, deeply affects SHG behavior and gives rise to a threshold level. The two main effects the modulated commutator has on this optical process are an inhibition of the SHG process at low pumping level and a significant (cubic) amplification of the second-harmonic signal production rate once the threshold is overcome (finally reaching the usual quadratic dependence at sufficiently high pumping level). Our predictions, which represent a concrete picture of a fractional quantum system, could be used to probe vacuum field fluctuations present in high-confinement microresonators and emphasize the fundamental importance of vacuum field fluctuations.