In this paper, a differential quadrature method of high-order precision (DQ−Pade), which is equivalent to the generalized Pade approximation for approximating the end of a time or spatial interval, is used to solve nonlinear fully intrinsic equations of beams. The equations are a set of first-order differential equations with respect to time and space, and the explicit unknowns of the equations involve only forces, moments, velocity and angular velocity, without displacements and rotations. Based on the DQ−Pade method, the spatial and temporal discrete forms of fully intrinsic equations were derived. To verify the effectiveness and applicability of the proposed method for discretizing the fully intrinsic equations, different examples available in the literatures were considered. It was found that when using the DQ−Pade method, the solutions of the intrinsic beam equations are obviously superior to those found by some other usual algorithms in efficiency and computational accuracy.