THE purpose of this report is to present and correlate some roentgenologic and anatomic changes occurring in the growing skeleton during both clinical and experimental lead poisoning, and to consider the roentgenologic sequelæ in the bones of two children who recovered from chronic lead poisoning. The selective deposition of lead in the skeleton has been clearly shown in the extensive studies of Minot and Aub (1). Their demonstration chemically of lead storage in bone first suggested to me that retention of lead in bones might also be shown roentgenologically. Aub and his co-workers (2) concluded that a high concentration of lead occurs in the solid portion of the bone, whereas the marrow contains only traces of lead. They did not mention the ends of the diaphyses as special sites of lead deposit. We had anticipated that the roentgenologic findings in lead poisoning might be a generalized increase in bone density. Therefore, the pronounced changes limited to the ends of the shafts first seen in Case 1, October, 1929, were unexpected. Case 1. M. K., 18 months of age, was admitted to the Babies' Hospital on Oct. 21, 1929, from the Out-patient Department, with the diagnosis of chronic poisoning by lead. The familial, natal, and developmental histories were normal. Three months previously the child had begun to vomit. The vomiting had increased in both frequency and severity until, during the few weeks just past, emesis had occurred after all attempts to take food or even water. About four months previous to admission there had been a decided change in the child's disposition and activity. This previously normal child had become hyperirritable, crying most of the day and “shaking continually and waving her arms frantically in the air.” The infant had begun to walk about the fourteenth month, and the mother thought that she had walked as well as most children of this age, until the last two months before admission to the hospital, when she “fell down frequently” and finally stopped walking (one month before). Attempts to encourage her to begin walking again were unsuccessful. The child “staggered badly.” No convulsive seizures had been observed. She was supposed to have gained normally during this time. Two and one-half months before admission, pallor was first noted, which had gradually increased up to the day of admission. The mother offered the information that at the fourteenth month, the approximate date when she started to walk, the infant was first seen to chew on the painted surfaces of woodwork about the household—window-cases, doors, crib, beds, and chairs. This perversion of appetite had continued throughout the last four months, and during this time several “large areas of paint had been chewed off” these surfaces. Physical Examination Measurements: head 18½ inches, length 30¼ inches.