The gender gap is persistent across areas of health in our society, irrespective of poor- rich, caste, religion and geographical areas. The objective of the present study is to understand the effect of gender and age differences on the stress, health and well-being. The sample consisted of 100(50-Male and 50-Female). These two groups male and female were further into two groups’ i.e. younger group and older group. Each group comprises 25 males and 25 female. The respondents were assessed on Stress Scale, PGI- Health questionnaire and General Well-Being Measure. On ANOVA, the results showed significant effect of gender as well as age on the measure of well being and interaction effect showed significant effect. Younger group have more stress than older group. On Well-Being, the results showed female and older group has better well being than male and younger group.