General Activity Level Research Articles

Activity Density Map Visualization and Dissimilarity Comparison for Eldercare Monitoring

In this paper, we present a methodology for analyzing passive infrared motion sensor data logged in the homes of seniors. The objective is to capture activity patterns that represent different health conditions. Recognizing changes in the activity patterns can then be used to provide early detection of health changes. A visualization of motion sensor data is introduced in the form of a density map that uses different colors to show varying levels of activity. For evaluating the activity density level accurately, time away from home is determined first using a system of fuzzy rules. In addition, a dissimilarity between two density maps is computed using texture features for automatically determining changes in activity patterns, which may indicate a health problem. The activity density maps are being used in an aging in place senior housing community to aid clinicians in early illness detection. Three case studies of elderly residents are included to illustrate how the density map and dissimilarity measure can be used to track general activity level and daily patterns over time, showing changes in physical, cognitive, and mental health.

How accurate are VAT registrations as a measure of entrepreneurship?

Comparing VAT registration data with Scottish Clearing Bank Statistics on new start-up activity we assess the extent to which VAT registration data reflect the general level of start-up activity in the Scottish economy for the period 2002–2009. Findings reveal that VAT registration data underestimate the general level of start-up activity by 39%. The data also reveal there is considerable spatial variation in start-up activity across Scottish regions and the recent recession has affected start-up activity irrespective of which measure is used. It is also clear, however, that the recession has affected the general level of start-up activity to a far greater extent.

Lower Extremity-Specific Measures of Disability and Outcomes in Orthopaedic Surgery

Outcome measures may be simple questions or complex measures that assess multiple interrelated domains affecting treatment outcomes. Outcome measures should be relevant to patients, easy to use, reliable, valid, and responsive to clinical changes. Joint and disease-specific outcome measures have been developed for the hip, knee, and foot and ankle. Many of these measures would benefit from further research into their validity, reliability, and optimal applicability. General health measures and activity level scores should be included in outcome assessments after treatment for orthopaedic conditions.

Catalytic Conversion of Syngas into Higher Alcohols over Carbide Catalysts

This work investigates the use of the bulk carbides Mo2C, WC, and NbC as catalysts for the conversion of syngas into higher alcohols. K2CO3/WC produces mainly CH3OH and CH4 with a low activity. NbC has a very low activity in CO hydrogenation. K2CO3/Mo2C produces mixed alcohols with a reasonable activity and selectivity. In a 94 h test the activity and the specific surface area of the K2CO3/Mo2C catalyst decreased significantly, but X-ray diffraction and transmission electron microscopy did not indicate a strong sintering of the carbide. A likely cause for the deactivation is the formation of carbonaceous deposits on the catalyst. At the same general activity level Li, K, and Cs provide similar promotional effects for Mo2C, although K at a loading level of alkali metal/Mo = 0.164 mol/mol provides the better behavior at equal conditions. The effect of further additives on the K2CO3/Mo2C system was evaluated, but only Cu yielded an improvement.

Modelling seasonality in Australian building approvals

The paper examines the impact of seasonal influences on Australian housing approvals, represented by the State of Victoria[1] building approvals for new houses (BANHs). The prime objective of BANHs is to provide timely estimates of future residential building work. Due to the relevance of the residential property sector to the property sector as whole, BANHs are viewed by economic analysts and commentators as a leading indicator of property sector investment and as such the general level of economic activity and employment. The generic objective of the study is to enhance the practice of modelling housing variables. In particular, the study seeks to cast some additional light on modelling the seasonal behaviour of BANHs by: (i) establishing the presence, or otherwise, of seasonality in Victorian BANHs; (ii) if present, ascertaining is it deterministic or stochastic; (iii) determining out of sample forecasting capabilities of the considered modelling specifications; and (iv) speculating on possible interpretation of the results. To do so the study utilises a structural time series model of Harwey (1989). The modelling results confirm that the modelling specification allowing for stochastic trend and deterministic seasonality performs best in terms of diagnostic tests and goodness of fit measures. This is corroborated with the analysis of out of sample forecasting capabilities of the considered modelling specifications, which showed that the models with deterministic seasonal specification exhibit superior forecasting capabilities. The paper also demonstrates that if time series are characterized by either stochastic trend or seasonality, the conventional modelling approach[2] is bound to be mis-specified i.e. would not be able to identify statistically significant seasonality in time series.According to the selected modeling specification, factors corresponding to June, April, December and November are found to be significant at five per cent level. The observed seasonality could be attributed to the ‘summer holidays’ and ‘the end of financial year’ seasonal effects. [1] Victoria is geographically the second smallest state in Australia. It is also the second most populous state in Australia. Australia has six states (New South Wales, Queensland, South Australia, Tasmania, Victoria, and Western Australia), and two territories (the Northern Territory and the Australian Capital Territory).[2] A modelling approach based on the assumption of deterministic trend and deterministic seasonality.

Tourist activity: international and domestic diversification and the problem of social exclusion

This article presents the international and domestic diversification of tourist activity. In the former case, it focuses on analyses of the general level of tourist activity, expressed in the ‘tourist activity rate’, while with regards to the inhabitants of Poland, analyses were conducted on the diversification of tourist activity across various socio-demographic categories. For international comparisons, the wide-ranging research conducted by EUROSTAT in 2011 on representative samples of the inhabitants of 32 European countries was used. The diversification of Polish tourist activity in the context of social exclusion, on the other hand, is presented on the basis of the author's research and calculations. Statistical analyses were employed: Kendall's Tau-b rank correlation coefficient and cluster analysis.

Research of Humen Fall Detection Algorithm Based on Tri-Axis Accelerometer

The real-time monitoring of human movement can provide valuable information regarding an individual’s degree of functional ability and general level of activity. This paper presents a fall-detection technology based on tri-axial accelerometer sensor was introduced. The acceleration data of the activities with the characteristic quantity SVM and SMA was analyzed. A method based on SVM and SMA, that takes the human body activity (erectness/lies down) as the auxiliary criterion to distinguish fall and ADL is proposed, and concrete threshold value and related parameters are summarized in this article. The experiment results proved that this scheme can obtain highly rate of accuracy and this algorithm has very good timeliness.

Kastration von Hunden aus Sicht der Tierverhaltenstherapie

The castration of dogs is an amputation covered by Section 6 (1) of the Animal Protection Law in Germany. Apart from the general indications given by veterinary medicine, castration of an animal is a potential method of animal behaviour therapy. However, the highly variable, individual effects of castration on behaviour require detailed diagnosis by the veterinarian. Castration appears to exert its strongest influence on sexually dimorphic behaviour patterns in male dogs, e.g. status- related aggression, urine marking, mounting, house-soiling problems, and roaming. An indication to castrate a bitch is maternal aggression. When evaluating the effects of castration, one should always consider individual circumstances, such as learning experience (for example in the case of "experienced copulators"), age, and pack behaviour (if there is more than one dog in the household). Additional benefits of castration include a reduction in the dog's general activity level, decreased preparatory arousal and a decline in the dog's ability to focus its attention fully on the target of attack. As a result, it is much easier for the owner to disrupt and manage or control the dog's agonistic intentions. However, castration is not the ultimate remedy in dog-handling. Any decision in this respect should be based on a precise behaviour- related indication. Otherwise, such surgery may well violate the Animal Protection Law.

Rethinking the Possibilities and Limitations of a Study on the Skeletal Markers Reconstructing the General Level of Physical Activity

Rethinking the Possibilities and Limitations of a Study on the Skeletal Markers Reconstructing the General Level of Physical Activity

Television viewing, television content, food intake, physical activity and body mass index: a cross-sectional study of preschool children aged 2–6 years

The mechanisms underlying the relationship between television (TV) viewing and weight status in preschool aged children are not well understood. This study aimed to explore the relationships between preschool children's TV viewing habits (i.e. time spent viewing, content watched and foods eaten while viewing), daily food intake, general physical activity levels and their body mass index (BMI). A cross-sectional sample of preschool children in Melbourne (n = 135). Mothers of preschoolers completed a 3-day TV diary; information was collected on viewing time, content and food consumed while watching TV. Mothers also reported their child's height, weight and physical activity behaviour. Associations between study and outcome variables were determined by bivariate correlations and hierarchical regression analyses. Mean age of preschoolers was 4.5 years and 14% were overweight or obese. The mean daily time spent watching TV was 90.7 minutes (SD 50.7) A small, positive correlation was found between viewing TV on weekdays and child BMIz, (p<0.05). This effect was moderate when controlled for total kilojoules consumed while watching TV (on weekdays) and number of minutes spent in sedentary activities (across three days). This study suggests that TV viewing may affect preschool child weight status through displacement of physical activity or eating while viewing.

Recent and Past Musical Activity Predicts Cognitive Aging Variability: Direct Comparison with General Lifestyle Activities

Studies evaluating the impact of modifiable lifestyle factors on cognition offer potential insights into sources of cognitive aging variability. Recently, we reported an association between extent of musical instrumental practice throughout the life span (greater than 10 years) on preserved cognitive functioning in advanced age. These findings raise the question of whether there are training-induced brain changes in musicians that can transfer to non-musical cognitive abilities to allow for compensation of age-related cognitive declines. However, because of the relationship between engagement in general lifestyle activities and preserved cognition, it remains unclear whether these findings are specifically driven by musical training or the types of individuals likely to engage in greater activities in general. The current study controlled for general activity level in evaluating cognition between musicians and nomusicians. Also, the timing of engagement (age of acquisition, past versus recent) was assessed in predictive models of successful cognitive aging. Seventy age and education matched older musicians (>10 years) and non-musicians (ages 59–80) were evaluated on neuropsychological tests and general lifestyle activities. Musicians scored higher on tests of phonemic fluency, verbal working memory, verbal immediate recall, visuospatial judgment, and motor dexterity, but did not differ in other general leisure activities. Partition analyses were conducted on significant cognitive measures to determine aspects of musical training predictive of enhanced cognition. The first partition analysis revealed education best predicted visuospatial functions in musicians, followed by recent musical engagement which offset low education. In the second partition analysis, early age of musical acquisition (<9 years) predicted enhanced verbal working memory in musicians, while analyses for other measures were not predictive. Recent and past musical activity, but not general lifestyle activities, predicted variability across both verbal and visuospatial domains in aging. These findings are suggestive of different use-dependent adaptation periods depending on cognitive domain. Furthermore, they imply that early age of musical acquisition, sustained and maintained during advanced age, may enhance cognitive functions and buffer age and education influences.

Effect of dexamethasone on activity of glycosidases and proreinases of intestine of sterlet Acipenser ruthenus

Effect of dexamethasone (2.0 mg/kg) on activity of enzymes hydrolyzing proteinaceous and carbohydrate food components in the intestine of the starlet Acipenser ruthenus is studied. Dexamethasone modifies the activity of proteinases more than of glycosidases. As a rule, the hormone significantly decreases the level of proteolytic and general amylolytic activity of the intestinal mucosa and chyme in comparison with intact fish on the first day into the experiment and increases it on the 7th or 14th day. The dynamics of activity was different in enzymes of different chains (glycosidase and proteinase) and preparations (the mucosa and chyme).

The periaqueductal gray as a critical site to mediate reward seeking during predatory hunting

Previous studies using morphine-treated dams reported a role for the rostral lateral periaqueductal gray (rlPAG) in the behavioral switching between nursing and insect hunting, likely to depend on an enhanced seeking response to the presence of an appetitive rewarding cue (i.e., the roach). To elucidate the neural mechanisms mediating such responses, in the present study, we first observed how the rlPAG influences predatory hunting in male rats. Our behavioral observations indicated that bilateral rlPAG NMDA lesions dramatically interfere with prey hunting, leaving the animal without chasing or attacking the prey, but do not seem to affect the general levels of arousal, locomotor activity and regular feeding. Next, using Phaseolus vulgaris-leucoagglutinin (PHA-L), we have reviewed the rlPAG connection pattern, and pointed out a particularly dense projection to the hypothalamic orexinergic cell group. Double labeled PHA-L and orexin sections showed an extensive overlap between PHA-L labeled fibers and orexin cells, revealing that both the medial/perifornical and lateral hypothalamic orexinergic cell groups receive a substantial innervation from the rlPAG. We have further observed that both the medial/perifornical and lateral hypothalamic orexinergic cell groups up-regulate Fos expression during prey hunting, and that rlPAG lesions blunted this Fos increase only in the lateral hypothalamic, but not in the medial/perifornical, orexinergic group, a finding supposedly associated with the lack of motivational drive to actively pursue the prey. Overall, the present results suggest that the rlPAG should exert a critical influence on reward seeking by activating the lateral hypothalamic orexinergic cell group.

Mouse model of Timothy syndrome recapitulates triad of autistic traits

Autism and autism spectrum disorder (ASD) typically arise from a mixture of environmental influences and multiple genetic alterations. In some rare cases, such as Timothy syndrome (TS), a specific mutation in a single gene can be sufficient to generate autism or ASD in most patients, potentially offering insights into the etiology of autism in general. Both variants of TS (the milder TS1 and the more severe TS2) arise from missense mutations in alternatively spliced exons that cause the same G406R replacement in the Ca(V)1.2 L-type calcium channel. We generated a TS2-like mouse but found that heterozygous (and homozygous) animals were not viable. However, heterozygous TS2 mice that were allowed to keep an inverted neomycin cassette (TS2-neo) survived through adulthood. We attribute the survival to lowering of expression of the G406R L-type channel via transcriptional interference, blunting deleterious effects of mutant L-type channel overactivity, and addressed potential effects of altered gene dosage by studying Ca(V)1.2 knockout heterozygotes. Here we present a thorough behavioral phenotyping of the TS2-neo mouse, capitalizing on this unique opportunity to use the TS mutation to model ASD in mice. Along with normal general health, activity, and anxiety level, TS2-neo mice showed markedly restricted, repetitive, and perseverative behavior, altered social behavior, altered ultrasonic vocalization, and enhanced tone-cued and contextual memory following fear conditioning. Our results suggest that when TS mutant channels are expressed at levels low enough to avoid fatality, they are sufficient to cause multiple, distinct behavioral abnormalities, in line with the core aspects of ASD.

Increased consumption of ethanol and sugar water in mice lacking the dopamine D2 long receptor

Individual differences in dopamine D2 receptor (D2R) expression in the brain are thought to influence motivation and reinforcement for ethanol and other rewards. D2R exists in two isoforms, D2 long (D2LR) and D2 short (D2SR), produced by alternative splicing of the same gene. The relative contributions of D2LR versus D2SR to ethanol and sugar water drinking are not known. Genetic engineering was used to produce a line of knockout (KO) mice that lack D2LR and consequently have increased expression of D2SR. KO and wild-type (WT) mice of both sexes were tested for intake of 20% ethanol, 10% sugar water and plain tap water using established drinking-in-the-dark procedures. Mice were also tested for effects of the D2 antagonist eticlopride on intake of ethanol to determine whether KO responses were caused by lack of D2LR or overrepresentation of D2SR. Locomotor activity on running wheels and in cages without wheels was also measured for comparison. D2L KO mice drank significantly more ethanol than WT in both sexes. KO mice drank more sugar water than WT in females but not in males. Eticlopride dose dependently decreased ethanol intake in all groups except male KO. KO mice were less physically active than WT in cages with or without running wheels. Results suggest that overrepresentation of D2SR contributes to increased intake of ethanol in the KO mice. Decreasing wheel running and general levels of physical activity in the KO mice rules out the possibility that higher intake results from higher motor activity. Results extend the literature implicating altered expression of D2R in risk for addiction by delineating the contribution of individual D2R isoforms. These findings suggest that D2LR and D2SR play differential roles in consumption of alcohol and sugar rewards.

Temperament Alters Susceptibility to Negative Peer Influence in Early Adolescence

The role of deviant peers in adolescent antisocial behavior has been well documented, but less is known about individual differences in susceptibility to negative peer influence. This study examined whether specific temperament dimensions moderate the prospective relationship between peer deviance and delinquent behavior in early adolescence. Participants included 704 adolescents recruited from the community. At baseline, parents provided information on adolescents' temperament and youth reported on their own and their friends' delinquent behavior. Self-reports of adolescents' delinquent behavior were collected again 16 months later. Peer deviance was related to delinquent behavior over time more strongly for adolescents with low levels of task orientation, flexibility, and positive mood, compared to youth with high levels of task orientation, flexibility, and positive mood. Analyses of gender differences indicated that low flexibility increased susceptibility to negative peer influence only for males, but not females. General activity level and sleep rhythmicity did not moderate the effect of peer behavior on delinquency.

The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice

Due to genetic defects or illness some individuals require higher amounts of thiamin than are typically provided by the diet. Lipid-soluble thiamin precursors can achieve high blood levels of thiamin and result in increased concentrations in the central nervous system. High intakes of thiamin have been reported as beneficial in children with autism and attention deficit/hyperactivity disorder. The current study examined the effect of thiamin tetrahydrofurfuryl disulfide (TTFD), a lipophilic precursor, on behavior in the juvenile male DBA/2J mouse. Mice given by oral gavage deionized water or deionized water providing 100mg or 340mg TTFD/kg body weight daily for 17d, starting at postnatal day 18, were tested for effects on operant learning, social interaction, general activity level, and prepulse inhibition of acoustic startle, as well as effects on growth and select organ weights. Results indicate lower activity and altered social interaction at both treatment levels and decreased acoustic startle at the 100mg/kg level. Compared to controls, percent weight gain was lower in the TTFD-treatment groups, but percent body length increase was not affected by TTFD treatment. TTFD treatment did not influence percent organ weights as percentage of body weights. TTFD treatment resulted in increased whole brain thiamin concentrations. These results support the concept that lipophilic thiamin precursors provided during early development can affect a number of behavioral parameters. In clinical trials with children with behavior disorders, attention should be given to preventing possible adverse gastrointestinal irritant effects associated with TTFD therapy.

MicroRNA regulation of homeostatic synaptic plasticity

Homeostatic mechanisms are required to control formation and maintenance of synaptic connections to maintain the general level of neural impulse activity within normal limits. How genes controlling these processes are co-coordinately regulated during homeostatic synaptic plasticity is unknown. MicroRNAs (miRNAs) exert regulatory control over mRNA stability and translation and may contribute to local and activity-dependent posttranscriptional control of synapse-associated mRNAs. However, identifying miRNAs that function through posttranscriptional gene silencing at synapses has remained elusive. Using a bioinformatics screen to identify sequence motifs enriched in the 3'UTR of rapidly destabilized mRNAs, we identified a developmentally and activity-regulated miRNA (miR-485) that controls dendritic spine number and synapse formation in an activity-dependent homeostatic manner. We find that many plasticity-associated genes contain predicted miR-485 binding sites and further identify the presynaptic protein SV2A as a target of miR-485. miR-485 negatively regulated dendritic spine density, postsynaptic density 95 (PSD-95) clustering, and surface expression of GluR2. Furthermore, miR-485 overexpression reduced spontaneous synaptic responses and transmitter release, as measured by miniature excitatory postsynaptic current (EPSC) analysis and FM 1-43 staining. SV2A knockdown mimicked the effects of miR-485, and these effects were reversed by SV2A overexpression. Moreover, 5 d of increased synaptic activity induced homeostatic changes in synaptic specializations that were blocked by a miR-485 inhibitor. Our findings reveal a role for this previously uncharacterized miRNA and the presynaptic protein SV2A in homeostatic plasticity and nervous system development, with possible implications in neurological disorders (e.g., Huntington and Alzheimer's disease), where miR-485 has been found to be dysregulated.

The influence of D. melanogaster mutations of the kynurenine pathway of tryptophan metabolism on locomotor behavior and expression of genes belonging to glutamatergic and cholinergic systems

Disbalance of kynurenines produced by Drosophila mutations of the kynurenine pathway of tryptophan metabolism influences the locomotor behavior in larvae. The most pronounced is the effect of accumulation of kynurenic acid in the mutant cinnabar manifested as sharp reduction of general level of locomotor activity. The mutations seem to act through modulatory influences of kynurenines on signal cascades governed by ionotropic glutamatergic and cholinergic receptors. Expression of receptor genes in the mutants shows age-related changes pointing to gradual evolvement of consequences of kynurenines disbalance.

Effects of Installing Fitness Zone Equipment on Park Use and Physical Activity Levels

While community parks are important settings for the accrual of physical activity (PA), they are often underused. Commercial outdoor Fitness Zones (FZ) are available for installation, but there is little objective data on population use of the equipment and whether it has an impact on general park use and participant activity levels. PURPOSE: To objectively assess installation of FZ on both equipment and general park use in 12 settings. METHODS: We evaluated FZ installation in 6 City and 6 County parks. Prior to installation we measured use of all activity areas in each park using SOPARC 3 times per day (morning, noon, evening) on 2 weekdays and 2 weekend days. SOPARC uses direct observation to assess both park and user characteristics, including gender, age, race/ethnicity, and activity levels. After FZ installation we did the same measures twice (winter and spring, 2010), while also observing FZ areas hourly for 10 hours per day for each of the 4 days. We also interviewed FZ and other park area users. RESULTS: Over the 3 time periods we observed 23,557 people in the 12 parks (including 2,545 in FZ) and interviewed 2,637 (including 722 in FZ). FZ were used throughout the day. Compared to baseline, overall park use increased 16% during the first follow-up and 3% during the second, with increases concentrated in 4 city and 2 county parks-primarily those with a larger population density. FZ attracted more new users to parks than other park areas. FZ users reported coming to the park more frequently and engaging in more exercise sessions than other park users: while there they engaged in more moderate to vigorous physical activity (MVPA) (65.7% vs. 33.1% at first follow-up; 71.8% vs. 36.7% at second follow-up). Compared to baseline, MVPA increased in non FZ areas by 12% at the first follow up and 10% at the second. CONCLUSIONS: Adding FZ may attract new park users and increase MVPA in parks, even in areas beyond FZ. FZ may have their greatest impact in parks in densely populated communities and in smaller parks that have few facilities and amenities. Supported by Active Living Research/RWJ Foundation, NHLBI, TPL, and the Kaiser Foundation.