Transcranial direct current stimulation (tDCS) is a non-invasive technique that can induce LTP/LTD-like plasticity in the stimulated area ( Fritsh, 2010 ). The electrical field generated by the stimulation modulates cortical activity according to polarity of the current: anodal stimulation (A-tDCS) has been shown to increase cortical excitability and cathodal stimulation (C-tDCS) to decrease cortical excitability ( [Bindman, 1964] , [Nitsche and Paulus, 2000] ). In this study we have combined tDCS with motor practice in order to evaluate if tDCS may enhance plasticity and learning through gating mechanisms or may trigger compensatory mechanisms of metaplasticity ( [Ziemann and Siebner, 2008] , [Pozo and Goda, 2010] ). To this aim, we ran two experiments: in the first experiment, the motor practice (MP) task consisted of fast thumb abduction movements (F-MP) of the left hand, which induce learning ( Muellbacher, 2002 ). In the second experiment, the motor practice task consisted of slow thumb abduction movements (S-MP), which do not induce learning. In both experiments, six blocks of MP (corresponding to 20 min) were performed while tDCS was delivered at 1.5 mA (electrode surface 25 cm 2 ; current density 0.06 mA/cm 2 ) on contralateral M1. Moreover, two blocks with fast thumb abduction were performed, one before and one after tDCS application. Peak acceleration in the fast thumb abduction blocks was used as measure of performance. Results showed a general learning effect when participants performed the F-MP task. Moreover, learning rates varied across stimulation conditions. A-tDCS reduced performance compared to sham in the early phase of learning, and C-tDCS increased performance compared to A-tDCS in the latter phase of learning. When participants performed the S-MP task, performance improved after A-tDCS, whereas no learning effect was found in the sham stimulation condition. Therefore, our results highlight that tDCS-induced plasticity in the motor cortex is state-dependent: When applied during a MP task that does not induce learning, A-tDCS increased performance. When applied during motor learning, A-tDCS interfered with performance, suggesting that the concurrent combination of tDCS with another plasticity-inducing protocol may trigger compensatory mechanisms of metaplasticity.