A timely health examination is of great significance for incipient disease detection and prevention. However, conventional examinations generally rely heavily on bulky and expensive instrumentation, which is not easily available. To address technical barriers, an innovative, highly miniaturized, and integrated health examination system-Mobile Health Examination Launched on the Phone (M-HELP)-was developed. Based on the design of a multifunctional Android® (Google, Mountain View, CA) application and the development of different wireless biomedical sensor modules, a mobile phone was incorporated into a central terminal for personal health examination. More than 12 parameters, including electrocardiogram, heart sound, and eye test, as well as others, covered the majority of the crucial parameters in a total health examination and have been successfully established and incorporated into the system. Unlike the conventional examination, the M-HELP system could generate electronic health records and send them to physicians via e-mails or multimedia messages. This significantly simplifies the general health examination with much lower cost and fewer temporal and spatial restrictions. For proof of concept, a bench-scale test recruiting 11 volunteer subjects showed that the average time spent on a total health examination with M-HELP system was about 28 min. This article clarifies the basic concept of a total health examination on the platform of a mobile phone, demonstrates the basic features of the M-HELP system with group tests, and suggests the practical future application of the new system and the scientific issues thus raised.