ABSTRACT The response of the Maroon reservoir in southwest Iran is modeled to evaluate possible impacts of 21st century climate change. Projections of 3 CMIP5 General Circulation Models (GCMs) were investigated using 2 Representative Concentration Pathways (RCP4.5 and RCP8.5), which respectively represent low/medium and high greenhouse gas emission scenarios. The raw GCM projections are statistically bias-corrected to provide boundary conditions for the 3-dimensional Aquatic Ecosystem Model (AEM3D). A new overturn bias analysis method was developed to evaluate possible bias in the GCM predictors during the observational (historic) period and determined it to be negligible. The modeling results, quantified by the analysis of various limnological parameters (onset and length of mixing and stratification periods, hypolimnion and epilimnion thickness and temperature, Brunt-Väisälä frequency, and Schmidt stability) indicate for RCP4.5 a continuous reduction in winter mixing and complete suppression of mixing by the end of the 21st century, implying a switch from monomictic to weakly oligomictic behavior. Under RCP8.5, the behavior transition occurs abruptly in the late 2050s in the form of a tipping point, followed by intermittent oligomictic behavior and transition to permanent stratification (thermal meromixis) within a decade. The change in behavior occurs because the surface and mixing temperatures significantly increase due to climate warming, whereas the hypolimnion is less affected, partly because of milder warming of cold winter river inflows (underflow) and strengthening stratification. The climate change-induced tipping point for the thermal regime of Maroon reservoir might serve as an indicator of changes in other warm monomictic systems.