General Appraisal Research Articles

Accumulation, biochemical responses and changes in the redox proteome promoted by Ag and Cd in the burrowing bivalve Scrobicularia plana

Silver (Ag) and cadmium (Cd) are non-essential metals that, as a result of natural processes and human activities, reach the aquatic environment where they interact with biota inducing potential toxic effects. To determine the biological effects of these metals on the endobenthic bivalve Scrobicularia plana, specimens were exposed to Ag and Cd at two concentrations, 5 and 50 μg∙L-1, for 7 days in a controlled microcosm system. The levels of the metals were measured in the seawater, sediments and clam tissues. The possible toxic biological effects of Ag and Cd were studied using a battery of biochemical biomarkers that are responsive to oxidative stress: superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione-S-transferase (GST) activities, and metallothioneins (MTs) and lipid peroxidation (LPO) levels. Since both metals have been linked to oxidative stress, redox modifications to proteins were studied by differential isotopic labelling of the oxidised and reduced forms of cysteines (Cys). An accumulation of metals was observed in the digestive gland and gills following exposure, together with the activation of enzyme activities (SOD for the Cd exposure; SOD, CAT, GST, and GR for the Ag exposure). The MT and LPO levels (after individual exposure to Ag and Cd) increased, which suggests the existence of antioxidant and detoxification processes to mitigate the toxic oxidative effects of both metals. The redox proteomic analysis identified 771 Cys-containing peptides (out of 514 proteins), of which 195 and 226 changed after exposure to Ag and Cd, respectively. Bioinformatics analysis showed that exposure to metal affects relevant functional pathways and biological processes in S. plana, such as: “cellular respiration” (Ag), “metabolism of amino acids” and “synthesis and degradation of proteins” (Ag and Cd), “carbohydrate metabolism” and “oxidative stress” (Cd). The proteomic approach implemented here is a powerful complement to conventional biochemical biomarkers, since it evaluates changes at the protein level in a high-throughput unbiased manner, thus providing a general appraisal of the biological responses altered by exposure to the contaminants.

The Determination of Capitalization Rate by the Remote Segments Approach: The Case of an Agricultural Land Appraisal

In the absence of comparative real estate data in the market segment of the property to be estimated, the appraiser may resort to income capitalization to estimate the market value. Often, however, the choice of which rate to apply is affected by subjective and arbitrary assessments. The estimation result can therefore be inaccurate and rather unclear. However, the Remote Segments Approach (RSA), through appropriate adjustments on the original values, prices, and incomes detected in the remote segments, makes it possible to arrive at an appraisal result consistent with estimative logic and real estate valuation standards. The proposed application illustrates the estimation of the market value of a specialized fruit orchard of avocado, which is to be considered new in relation to other fruit species already present in the reference area. The adjustments required by the RSA are solved with the General Appraisal System (GAS), defining the difference matrix based on relevant characters common to all segments considered. The application is carried out by comparing the segment in which the orchard being estimated falls (subject) with other remote market segments in which prices and incomes constituted by other tree crops are collected. The market value of the subject is derived by making adjustments to the prices and incomes observed in the remote segments of comparison with a comparison function constructed through relevant characters common to the segments considered. The comparison function makes it possible to arrive at the determination of the capitalization rate to be used in estimating the value of the fruit orchard by income approach. While it is based on the comparison of segments, the approach followed allows for a value judgment consistent with the estimation comparison and capable of providing a solution less conditioned by the appraiser’s expertise in the presence of particularly pronounced limiting conditions.

Percutaneous coronary intervention for bifurcation coronary lesions using optimised angiographic guidance: the 18th consensus document from the European Bifurcation Club.

The 2023 European Bifurcation Club (EBC) meeting took place in Warsaw in October, and the latest evidence for the use of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) to optimise percutaneous coronary interventions (PCI) on coronary bifurcation lesions (CBLs) was a major focus. The topic generated deep discussions and general appraisal on the potential benefits of IVUS and OCT in PCI procedures. Nevertheless, despite an increasing recognition of IVUS and OCT capabilities and their recognised central role for guidance in complex CBL and left main PCI, it is expected that angiography will continue to be the primary guidance modality for CBL PCI, principally due to educational and economic barriers. Mindful of the restricted access/adoption of intracoronary imaging for CBL PCI, the EBC board decided to review and describe a series of tips and tricks which can help to optimise angiography-guided PCI for CBLs. The identified key points for achieving an optimal angiography-guided PCI include a thorough analysis of pre-PCI images (computed tomography angiography, multiple angiographic views, quantitative coronary angiography vessel estimation), a systematic application of the technical steps suggested for a given selected technique, an intraprocedural or post-PCI use of stent enhancement and a low threshold for bailout use of intravascular imaging.

Attachment and borderline personality disorder as the dance unfolds: A quantitative analysis of a novel paradigm

Current research on personality disorders strives to identify key behavioural and cognitive facets of patient functioning, to unravel the underlying root causes and maintenance mechanisms. This process often involves the application of social paradigms — however, these often only include momentary affective depictions rather than unfolding interactions. This constitutes a limitation in our capacity to probe core symptoms, and leaves potential findings uncovered which could help those who are in close relationships with affected individuals. Here, we deployed a novel task in which subjects interact with four unknown virtual partners in a turn-taking paradigm akin to a dance, and report on their experience with each. The virtual partners embody four combinations of low/high expressivity of positive/negative mood. Higher scores on our symptomatic measures of attachment anxiety, avoidance, and borderline personality disorder (BPD) were all linked to a general negative appraisal of all the interpersonal experiences. Moreover, the negative appraisal of the partner who displayed a high negative/low positive mood was tied with attachment anxiety and BPD symptoms. The extent to which subjects felt responsible for causing partners’ distress was most strongly linked to attachment anxiety. Finally, we provide a fully-fledged exploration of move-by-move action latencies and click distances from partners. This analysis underscored slower movement initiation from anxiously attached individuals throughout all virtual interactions. In summary, we describe a novel paradigm for second-person neuroscience, which allowed both the replication of established results and the capture of new behavioural signatures associated with attachment anxiety, and discuss its limitations.

Reaction Space Charting as a Tool in Organic Chemistry Research and Development

AbstractThe chemical and reaction spaces are incredibly vast and special procedures are required to study them. Their complex and multiparametric nature encompass myriads of compounds and interactions and endless modifications involving the distinct impact of relevant variables (temperature, solvent, stoichiometry, etc.). This often calls for the design, collection, and analysis/interpretation of large datasets. Reaction charting, the systematic scanning, description, analysis, and guided modifications of a given process, stands as the most promising approach. It offers fast and accurate solutions as well as expanding the knowledge about the systems. This deeper understanding enables reliable predictions, improvement of the productivity (yields, scope), eventually leading to sustainable, economic, and safe applications. The present review introduces the topic, analyzing selected examples and recent advancements in different organic chemistry‐related fields. The covered methodologies range from classical experimentation modifying one factor at a time, to Design of Experiments and more modern computational approaches involving Machine Learning and Artificial Intelligence. In this way, the impact of charting in process development, biological and medicinal chemistry, catalysis, reaction discovery and computational methods is accounted. Finally, the conclusion/outlook section gives a general appraisal and a prospect on the future implementation of the methodology.

The Nature of Schadenfreude in Consumption Contexts: A Systematic Literature Review

This study aims to present a holistic perspective on schadenfreude in the context of consumption and to provide a framework that theoretically explains the social-psychological mechanisms behind consumers' schadenfreude. For this purpose, a systematic literature review integrating studies on schadenfreude in the context of consumption has been conducted in our current study. A systematic literature review that integrates studies on schadenfreude in consumption contexts is employed. Drawing on appraisal theory and social comparison framework, a general overarching framework explaining the market and consumption-related mechanisms that elicit schadenfreude and its consumer and brand-related outcomes is suggested. We argue that the elicitation of consumer schadenfreude is dependent on the appraisal of social comparisons. In this framework, the roles of the market and consumption-related factors behind the schadenfreude elicitation, uncovering the general appraisal structure behind this emotion are explained. By doing this, implications for the firms on how to manage this emotion in the marketplace and the potential consequences of schadenfreude emotion on different types of brand-related outcomes are provided.

Creating a common language for soundscape research: Translation and validation of Dutch soundscape attributes

Much of the work into the understanding of our auditory environment, referred to as soundscape research, has emerged from international and interdisciplinary research. This has enabled growth in understanding and increased opportunities for optimising shared environments but has also formed one major obstacle: a lack of a common language to describe soundscapes. Therefore, the purpose of this study is to validate translated soundscape descriptors in Dutch as part of the Soundscape Attributes Translation Project (SATP). For this, an expert panel of seven soundscape researchers from The Netherlands and Flanders (Belgium) translated the original eight English attributes into Dutch. Subsequently, following standardised materials and procedures, a sample of 32 Dutch participants completed a listening experiment in which they rated 27 audio files on the eight soundscape attributes. Results show modest evidence indicating that the Dutch translations were applied similarly to the original English attributes, with a slight (but not statistically significant) bias towards Pleasantness and Eventfulness in the Dutch sample. Bayesian analysis supports these findings by showing that the translations for the opposing attributes Uneventful and Annoying fit less well compared to the other attributes. Despite some limitations and while further research is necessary, our findings are promising and suggest that, although not perfect, the Dutch translations of the English soundscape attributes could already be useful for describing the general appraisal of a person's soundscape in The Netherlands.

Child Sexual Abuse (CSA) Using Hypnosis

Child sexual abuse (CSA) is a global problem and a serious public health issue. Perpetrators often resort to threats and force to incapacitate their victims, including using hypnosis. The use of hypnosis increases the level of difficulty of clinical forensic examination by presenting a diagnostic issue and complicating the formulation of forensic medical expert opinions. This evidence-based case report (EBCR) aims at assessing the available evidence concerning the forensic examination and diagnosis of hypnosis-facilitated CSA. A comprehensive computer-based literature search was performed using several keywords related to the clinical question. The search yielded seven relevant articles. The articles were appraised using general critical appraisal questions from the Centre for Evidence-Based Medicine, University of Oxford. All articles suggest that there might be a place for hypnosis in a criminal investigation (‘forensic hypnosis’). The evidence on the correct application of forensic hypnosis and its benefits are, however, still inconclusive and conflicting. In cases of suspected sexual assault using hypnosis, forensic hypnosis could potentially help memory recall of the victim and aid forward-thinking in drawing a clear and unambiguous conclusion for the forensic medical expert opinion.

Understanding the Paradoxical Effects of (Environmental) Activists and Their Discourses: When and How are They Penalized for Seeking Change?

ABSTRACT Activists are often negatively stereotyped and appraised, yet they can also influence the change they seek. This suggests that the dimensions and processes involved in their stereotyping and their influence are still unclear, as are the impacts of their argumentative style and the level of social consensus about the cause they defend. We focus on clarifying through an experimental study (n = 226): (1) how the argumentative style – radical or moderate – environmental activists employ and the level of societal consensus about their cause affect how they are viewed in three stereotypical dimensions (warmth, competence, and trustworthiness); (2) how these dimensions are associated with a general appraisal of the activist and with (3) respondents’ pro-environmental behavioral intentions. Results both corroborate and challenge previous findings, suggesting that activists are penalized on warmth, but not competence, that trustworthiness elicited by (radical) activists, and societal consensus play relevant roles. Suggestions for more nuanced communication strategies informed by these findings are discussed.

Does Exposure to Televised Debates Change the Weight of Different Criteria for Candidate Assessment? A Quasi-Experiment in the Context of the 2014 Spitzenkandidaten Debate

In this article, we show how exposure to debates primes specific candidate assessments as key factors of candidate appraisal. To fulfil this goal, we rely on quasi-experimental data collected in 24 European Union Member States and focus on a debate starred by largely unknown candidates (the 2014 European Spiztenkandidaten) engaged in a remarkably invisible campaign. Our results show that candidate perceptions become much more important factors of general candidate appraisal after the debate in the case of three out of the five lead candidates, namely those whose image benefitted from their participation in the debate. In several cases, personal likeability became more important in the general assessment of the Spitzenkandidaten, but there was also an increased relevance of the perceptions of leadership strength (Keller) and quality of the ideas to stimulate the European economy (Schulz and Tspiras). Moreover, in the cases of Schulz, Keller, and Tsipras, post-exposure candidate perceptions impacted more their general appraisal by participants without previous knowledge of them than by those who claimed to know them before the debate. Interestingly, leadership strength appraisal was more relevant for the former than for the latter participants. In short, by unveiling these patterns, this article not only provides evidence of the priming effects of debate exposure but also illustrates how such effects may vary according to citizens’ previous knowledge and the candidates’ general performance in the debate.

Which life domains are people with major depression satisfied or dissatisfied with? An individual patient data meta-analysis

BackgroundPeople with depression tend to score low on measures of subjective quality of life (SQoL) which has been suggested to reflect a general negative bias of perception. However, studies do not tend to investigate specific life domains. This study investigated satisfaction with life domains in people with major depression and explored influential factors. MethodsA one-step individual patient data meta-analysis combined data of 1710 people with major depression from four studies. In all studies, SQoL was measured on the Manchester Short Assessment of Quality of Life, which provides satisfaction ratings with 12 life domains. Associations between individual characteristics and satisfaction ratings were investigated using univariable and multivariable models. ResultsMean satisfaction ratings varied across life domains. Participants expressed dissatisfaction with several domains but expressed satisfaction with others, mainly for domains associated with close relationships. Some of the investigated characteristics were consistently associated with satisfaction ratings across the domains. LimitationsThe primary limitation of this study was in the analysis of individual characteristics, which were chosen based on identification in existing literature and availability in our datasets, and of which several were dichotomised to have sufficiently large numbers which may have resulted in lost nuance in the results. ConclusionsPeople with major depression distinguish between their satisfaction with different life domains and are particularly satisfied with their close relationships. This challenges the notion of a general negative appraisal of life in this group, and highlights the need to evaluate satisfaction with different life domains separately.

Prehospital Pediatric Emergency Training Using Augmented Reality Simulation: A Prospective, Mixed Methods Study

Objective Pediatric emergencies are high-stakes yet low-volume clinical encounters for emergency medical services (EMS) clinicians, necessitating innovative approaches to training. We sought to explore the acceptability, usability, and ergonomics of a novel augmented reality (AR) software for EMS crisis management training. Methods This was a prospective, mixed-methods study employing qualitative and quantitative analyses. We enrolled emergency medical technicians (EMTs) and paramedics at a municipal fire service in Northern California. We ran the Chariot Augmented Reality Medical simulation software (#details_redacted_for_peer_review) on the ML1 headset (Magic Leap, Inc., Plantation, FL), which enabled participants to view an AR image of a patient overlaid with real-world training objects. Participants completed a simulation of a pediatric hypoglycemia-induced seizure and cardiac arrest. Participants subsequently engaged in structured focus group interviews assessing acceptability, which we coded and thematically analyzed. We evaluated the usability of the AR system and ergonomics of the ML1 headset using previously validated scales, and we analyzed findings with descriptive statistics. Results Twenty-two EMS clinicians participated. We categorized focus group interview statements into seven domains after an iterative thematic analysis: general appraisal, realism, learning efficacy, mixed reality feasibility, technology acceptance, software optimization, and alternate use cases. Participants valued the realism and the mixed reality functionality of the training simulation. They reported that AR could be effective for practicing pediatric clinical algorithms and task prioritization, building verbal communication skills, and promoting stress indoctrination. However, participants also noted challenges with integrating AR images with real-world objects, the learning curve required to adapt to the technology, and areas for software improvement. Participants favorably evaluated the ease of use of the technology and comfortability of wearing the hardware; however, most participants reported that they would need technical support. Conclusion Participants positively evaluated the acceptability, usability, and ergonomics of an AR simulator for pediatric emergency management training, and participants identified current technological limitations and areas for improvement. AR simulation may serve as an effective training adjunct for prehospital clinicians.

Parental-Led Sexual Abuse Education Amongst At-Risk Parents: Associations with Parenting Practices, and Parent and Child Symptomology

ABSTRACT Considering the emphasis on parent-led sexual abuse education (PLSAE) in child sexual abuse (CSA) prevention, and the imperative of prevention in families living with demonstrated risk factors, it is important to understand the extent to which this group delivers PLSAE to their children, whether this is associated with any barriers or facilitators, whether parents are engaging in other protective behaviors (such as monitoring and involvement) and the relationship between these variables and other risk factors such as parent and child symptomology. We surveyed 117 parents, with children ranging in age from 25–89 months (67% boys), attending a parenting program for assistance with a range of parenting difficulties and child behavior problems from 2020–22. A large majority of parents reported not giving their children comprehensive prevention messages, discussing body integrity and abduction dangers to a greater extent. PLSAE was significantly positively associated with child internalizing and externalizing symptoms; parent and child age; and discussion of body integrity and abduction. However, PLSAE was not associated with any other measured variables (protective parenting; CSA knowledge; parenting self-efficacy; general and own-child risk appraisal; parent burnout, stress, depression or anxiety; child diagnosis; parental education level; employment or marital status; or income). The current findings suggest that investing resources into increasing parental knowledge, risk perception and confidence may be misguided. Future endeavors should consider helping parents be protective in other ways, for example, through the creation of safe environments and reducing the risks of CSA.

Change of government and interest groups' preference attainment on the formulation of the Italian National Recovery and Resilience Plan (NRRP): from Conte to Draghi

AbstractThis article focuses on how the 20 main Italian interest groups evaluated the contents of the Italian National Recovery and Resilience Plan (NRRP). In comparing its two versions (Conte Draft and Draghi Plan), we want to understand whether the change of government impacted on the contents of the NRRP and, in turn, on interest groups' preference attainment. To do so, we coded around 800 public statements following a multi-media approach. Interest groups' general appraisal for the NRRP grew with the change of government, while business groups greatly increased their degree of preference attainment. This within-case longitudinal comparison assesses the importance of governments' partisan composition to account for interest groups' success in the policymaking.

Neo-Gnosticism and the American Dissident Right

Neo-Gnosticism and the American Dissident Right

What constitutes a fulfilled life? A mixed methods study on lay perspectives across the lifespan.

Recently, we initiated a new research line on fulfillment in life by developing a conceptual framework and a self-report measure. To enhance conceptual clarity and complement theoretical considerations and empirical findings, we investigated lay conceptions of a fulfilled life in German-speaking participants at different life stages. First, we selected a qualitative approach using an open-ended question asking participants to describe a fulfilled life. Second, for a more comprehensive understanding, quantitative data were collected about the relevance of sources in providing fulfillment and ratings on a fulfilling life in the present and a fulfilled life in retrospect. Qualitative content analysis was used to assess the responses to the open-ended question. One-fifth of the data was double coded, and intercoder reliability was high (Kappa = 0.89). Responses comprised a variety of descriptions, and we grouped them into seven themes, three of which overlapped with the prior conceptualization, namely the core elements of (a) general description, (b) cognitive appraisals, and (c) affective appraisals. Cognitive evaluations related to intrapersonal aspects, particularly having lived life fully, attained personally significant goals, and developed oneself, as well as interpersonal, generative aspects, such as having made a contribution and been able to leave something of value. These categories are mostly in line with what the Fulfilled Life Scale (FLS) measures. Further themes referred to correlates—including (d) sources—and antecedents, including (e) resources, (f) personal characteristics, and (g) quality of life, all considered worthy to be the subject of empirical investigation but which were not included in the conceptual model. Qualitative and quantitative results suggest that individuals derive fulfillment from different sources. Fulfillment from a profession and having a life task was strongly associated with longer-term fulfillment. Only a few age and sex differences were found. The overarching framework developed from the qualitative results can stimulate further investigation. Our findings underscore that a fulfilled life as a distinct construct should be measured directly rather than via a proxy. Insights into the constituents, sources, and antecedents of a fulfilled life can inform practice to promote a life well lived.

Heterocycle-Based Multicomponent Reactions in Drug Discovery: From Hit Finding to Rational Design.

In the context of the structural complexity necessary for a molecule to selectively display a therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic approach is essential. Typically, thousands of relatively similar compounds should be prepared along the drug discovery process. In this respect, heterocycle-based multicomponent reactions offer advantages over traditional stepwise sequences in terms of synthetic economy, as well as the fast access to chemsets to study the structure activity relationships, the fine tuning of properties, and the preparation of larger amounts for preclinical phases. In this account, we briefly summarize the scientific methodology backing the research line followed by the group. We comment on the main results, clustered according to the targets and, finally, in the conclusion section, we offer a general appraisal of the situation and some perspectives regarding future directions in academic and private research.

The relationship between acceptance of illness and quality of life among men who have sex with men living with human immunodeficiency virus: A cross-sectional study

ObjectivesTo explore the relationship between acceptance of illness and quality of life (QOL), and factors associated with acceptance of illness among men who have sex with men (MSM) living with human immunodeficiency virus (HIV). MethodsThree hundred and one MSM were recruited from an HIV clinic between August and December 2018. The battery of measurements consisted of the Acceptance of Illness Scale, World Health Organization Quality of Life Questionnaire for HIV brief version, HIV Cognitive Appraisal Scale and a self-designed questionnaire used to collect general information. Pearson correlation test was used to examine the relationship between acceptance of illness and QOL. Univariate and multivariate ordinal logistic regression analyses were used to examine whether the general data (demographic and HIV-related clinical data) and HIV cognitive appraisal were associated with acceptance of illness levels. ResultsDescriptive analysis showed the acceptance level among MSM living with HIV was moderate (Mean = 26.29, SD = 5.28). Those with a better acceptance of illness had a better QOL (r = 0.69, P < 0.01). In the multivariate ordinal logistic regression model, education level, threat appraisals (OR:1.09; 95%CI [1.06–1.13]), and controllability appraisals (OR: 0.82; 95%CI [0.71–0.94]) were significantly associated with acceptance of illness. ConclusionsResults showed acceptance level was moderate and had a positive correlation with QOL. High level of education, low threat appraisals and high controllability appraisals were related to high illness acceptance. This finding highlights the importance of focusing on HIV-infected MSM with low education and on their perceptions of threat and controllability about HIV-related issues when designing interventions to promote illness acceptance in this vulnerable population.

Enhancing the learning of evolutionary anthropology skills by combining student-active teaching with actual and virtual immersion of Master's students in fieldwork, laboratory practice, and dissemination.

Higher education in evolutionary anthropology involves providing students with in‐depth knowledge of biological and cultural heritage sites and collections that are frequently inaccessible. Indeed, most sites, fossils, and archaeological remains can be visited or manipulated only rarely and solely by specialists with extensive experience. Owing to the development of 3D and medical imaging techniques, this fragile heritage is now more widely accessible, and in a dynamic way. However, exclusive adoption of virtual teaching and learning has a negative impact on student engagement and, naturally, on exchanges with instructors, and thus cannot be used without some reservations. In the ITAP (Immersion dans les Terrains de l’Anthropologie biologique et de la Préhistoire) project of the higher education STEP (Soutien à la Transformation et à l’Expérimentation Pédagogiques) transformation program at the University of Bordeaux, we combine student‐active teaching with Master's students fully immersed in ongoing fieldwork, laboratory study, and dissemination of research results in order to develop more individually shaped learning curricula and to foster both professional and new interdisciplinary skills. Here, we present examples of experiments conducted in the ITAP project using both authentic and virtual collections of archaeological, experimental, and reference materials that help to break down the barriers between research activities and higher education, as well as providing a more general appraisal of the appropriate use of virtual tools in higher education by combining them with real‐life situations.

Faecal microbiota transplantation for bipolar disorder: A detailed case study.

Faecal microbiota transplantation for bipolar disorder: A detailed case study.