Gender Differences In Posttraumatic Stress Disorder Research Articles

Gender Differences in Traumatic Experiences, PTSD, and Relevant Symptoms among the Iraqi Internally Displaced Persons.

Conflict in Iraq has led to a large number of internally displaced Iraqis, with a great impact on their mental health. A few previous studies investigated the gender differences of mental disorders in Iraqi internally displaced persons (IDPs). The aim of this study was to assess gender differences among Iraqi IDPs after the 2014 terrorist attacks in terms of types of traumatic experiences, prevalence of post-traumatic stress disorder (PTSD), and other symptoms of common mental disorders (depression, anxiety, and somatization symptoms). A cross-sectional survey was conducted in April–June 2015 among 358 female and 464 male adult IDPs living in IDP camps in Duhok, Iraq. The Harvard Trauma Questionnaire (HTQ), General Health Questionnaire (GHQ-28), and Self-Reporting Questionnaire (SRQ-20) were applied by local interviewers. Comparison of scores of these measures between the two genders was performed using independent sample t-tests. Logistic regression analysis was carried out to identify predictors for PTSD. Although the types of traumatic events experienced by female and male IDPs were nearly similar, males reported higher exposure to combat situation, torture, oppressions, and destruction of personal properties (t = 3.718 and 4.758, respectively, p < 0.001). Overall, males experienced more events than females (p < 0.001). The probable PTSD prevalence rates (29.1% among females and 31.9% among males) did not differ significantly (p = 0.212). Female IDPs reported more somatic (p < 0.001) and depressive/anxious (p < 0.001) symptoms than males. The demographic factors and duration of camp stay were not associated significantly with PTSD diagnosis. Probable PTSD rates among male and female IDPs in Iraq are substantial. Although no gender differences were found in probable PTSD rates between female and male Iraqi IDPs, the mean score of common mental disorders cases was higher among females and they presented with higher levels of somatic and depressive/anxious symptoms. Further studies are needed to clarify the underlying mechanisms contributing to gender differences in PTSD.

Post-traumatic stress disorder's relation with positive and negative emotional avoidance: The moderating role of gender.

Post-traumatic stress disorder (PTSD) is characterized by avoidance of trauma-related emotions. Research indicates that this avoidance may extend to any emotional experience that elicits distress, including those that are unrelated to the trauma. Literature in this area has been limited in its exclusive focus on negative emotions. Despite evidence of gender differences in PTSD and emotional avoidance separately, no studies to date have examined gender as a moderator of their association. The goal of the current study was to extend research by exploring the moderating role of gender in the relation between PTSD symptom severity and positive and negative emotional avoidance. Participants were 276 trauma-exposed individuals (65.9% female, 65.6% White, Mage = 19.24) from a university in the north-eastern United States. Moderation results indicated a main effect for PTSD symptom severity on both positive (b = 0.07, p < .001) and negative (b = 0.04, p = .03) emotional avoidance. The interaction of gender and PTSD symptom severity was significant for positive emotion avoidance (b = 0.97, p = .01). Analysis of simple slopes revealed that PTSD symptom severity was significantly associated with positive emotional avoidance for males (b = 0.13, p < .001) but not females (b = 0.03, p = .08). Results suggest the importance of gender-sensitive recommendations for assessment and treatment of emotional avoidance in PTSD.

Deployment-related trauma and post-traumatic stress disorder: does gender matter?

ABSTRACTObjective: Military research has attempted to identify whether women have an increased vulnerability to mental health issues following deployment-related trauma, but findings have been mixed. Most studies have controlled for childhood abuse, but not other non-deployment trauma (e.g. life-threatening illness), which may partly explain previous mixed results. This study assessed gender differences in the association between deployment-related trauma and post-traumatic stress disorder (PTSD) while controlling for non-deployment trauma.Methods: Data came from the 2013 Canadian Forces Mental Health Survey. Regular or reserve personnel who had been deployed at least once were included in this study (n = 5980). Logistic regression was used to examine the interaction between gender and deployment-related trauma in predicting lifetime PTSD.Results: After controlling for non-deployment trauma, the association of gender with PTSD went from being significant to being marginally significant. The interaction between gender and deployment-related trauma was not significant.Conclusion: Though controlling for non-deployment trauma did not completely dissipate gender differences in PTSD, such differences were greatly reduced, indicating that these may be partly related to traumatic experiences outside deployment. As gender did not moderate the link between deployment-related trauma and PTSD, the findings suggest that trauma experienced while on deployment does not disproportionately affect women compared to their male counterparts.

Impact of Gender on Child and Adolescent PTSD.

This review examines the recent literature on biological factors that influence sex differences in posttraumatic stress disorder (PTSD) during childhood and adolescence, focusing on neurobiological, hormonal, and genetic factors that may increase risk in girls. More than 60% of children and adolescents are exposed to traumatic events, and many develop PTSD. There is increasing recognition of gender differences in PTSD, with women having double the rates of the disorder compared to men. These gender differences in symptoms and their underlying neurobiology appear to emerge during adolescence, although it is still unclear which biological mechanisms may play key roles in the development of sex difference. The literature on gender effects in children and adolescents is still in the early stages, and more prospective and longitudinal work is needed; however, estrogen appears to play a key role in increasing risk for PTSD in girls, which emerges in adolescence.

Gender Differences in Posttraumatic Stress Disorder Among U.S. Navy Healthcare Personnel.

The role of women in the U.S. military has changed markedly over the course of 20th- and 21st-century conflicts. Although women frequently occupy healthcare positions in the military, little is known about gender differences in posttraumatic stress disorder (PTSD) within this occupational subgroup. A total of 4275 (667 women and 3608 men) U.S. Navy healthcare personnel supporting military operations in Iraq and Afghanistan were identified from electronic deployment records. Data from Post-Deployment Health Assessments were abstracted to identify PTSD screen positives, and to adjust for self-reported combat exposure and other deployment experiences. The prevalence of PTSD screen positive in the sample was 8.2% (n = 351/4275). After adjusting for combat exposure, previous psychiatric history, and demographics, women had significantly higher odds of screening positive for PTSD than did men (odds ratio = 1.99, 95% confidence interval 1.34-2.96). Interactions between gender and combat exposure, and between gender and previous psychiatric history were not statistically significant. This is one of the first studies to examine gender differences in PTSD among military healthcare personnel. Future research should account for additional stressors, such as long work hours, disrupted sleep patterns, and number of casualties treated. As women are further integrated into military occupations that may lead to different exposures, knowledge of gender differences in the manifestation of PTSD is paramount for prevention and treatment purposes.

The relationship between post traumatic stress disorder and post traumatic growth: gender differences in PTG and PTSD subgroups

This study investigated the post traumatic stress disorder (PTSD) and post traumatic growth (PTG) in 2,300 earthquake survivors 1 year after the 2008 Wenchuan earthquake. This study aimed to investigate the relationship between PTSD and PTG and also tested for the gender differences in PTSD and PTG subgroups. A stratification random sampling strategy and questionnaires were used to collect the data. The PTSD was assessed using the PTSD Check list-Civilian and the PTG was assessed using the Post traumatic growth inventory. 2,300 individuals were involved in the initial survey with 2,080 completing the final questionnaire, a response rate of 90.4%. One-way ANOVA analyses were performed to investigate the gender differences in the PTSD and PTG subgroups. One year following the earthquake, 40.1 and 51.1% of survivors reported PTSD and PTG, respectively. A bivariate correlation analysis indicated that there was a positive association between PTG and PTSD. The PTG and PTSD variance analysis conducted on female and male subgroups suggested that women were more affected than men. Given the relatively high PTG prevalence, it was concluded that researchers need to pay more attention to the positive outcomes of an earthquake rather than just focusing on the negative effects. The surveys and analyses indicated that psychological intervention and care for the earthquake disaster survivors should focus more on females and older people, who tend to be more adversely affected.

Targeting the endocannabinoid system to treat haunting traumatic memories

Targeting the endocannabinoid system to treat haunting traumatic memories

The traumatised chronic pain patient—Prevalence of posttraumatic stress disorder - PTSD and pain sensitisation in two Scandinavian samples referred for pain rehabilitation

Introduction Correctly identifying chronic pain patients with posttraumatic stress disorder (PTSD) is important because the comorbidity of a chronic pain condition and PTSD is found to compromise treatment success. In addition, the existence of PTSD is associated with pain sensitisation, elevated levels of pain, and disability. Furthermore, the diagnostic criteria for PTSD has changed dramatically in the last two decades which has had a profound impact on the reported prevalence rates of PTSD in chronic pain samples. To our knowledge, no study has employed the DSM-IV criteria for estimating the prevalence of PTSD in chronic pain patients referred consecutively for multidisciplinary pain rehabilitation. Aim The aim of the present study was to assess the prevalence of significant traumatic stressors and PTSD in chronic pain patients referred consecutively to multidisciplinary pain rehabilitation. We wanted to investigate whether specific pain diagnoses were more related to PTSD than others. Moreover, we investigated the possible association of altered sensory processing (hypersensitivity or hyposensitivity) and PTSD. Methods Data were collected from two Scandinavian multidisciplinary pain centres (Denmark and Finland). All patients referred consecutively were assessed for PTSD and sensitisation at admission. A total of 432 patients were assessed, of which 304 (DK, N = 220, female n = 144; FIN, N = 84, female n = 44) were admitted and consented to participate. All patients had to be diagnosed with a non-malign chronic pain condition lasting for at least 6 months (median = 6.0 years). The Harvard Trauma Questionnaire was employed to measure PTSD symptoms, using the DSM-IV criteria. To measure altered sensory processing, anaesthetists performed quantitative sensory testing on admission. Patients were asked to report if cold, brush, and pinprick mechanical stimulation resulted in decreased or increased sensation or pain. Results A high prevalence of PTSD was found in both consecutive samples. Using the DSM-IV criteria, 23% fulfilled the criteria for a possible PTSD diagnosis. There were no gender differences in PTSD. The three most reported traumatic events: traffic accidents, serious illness personally or in the family, and the actual loss of someone, were reported as the primary traumatic events by almost 50% of those with PTSD. No particular pain diagnosis was significantly related to PTSD. However, hypersensitivity to cold and hyposensitivity to brush were significantly associated with PTSD. Discussion The prevalence of PTSD in the present study was 23%. Earlier studies finding a lower prevalence rate of PTSD may reflect the use of older diagnostic criteria for PTSD or other estimates, for instance PTSD symptom cut-off scores. Conclusion The study emphasised the importance of screening all chronic pain patients for PTSD at admission for pain rehabilitation, using up to date diagnostic tools. Implications Untreated PTSD may exacerbate or maintain the pain condition and negatively affect outcome of pain rehabilitation.

Gender Differences in Animal Models of Posttraumatic Stress Disorder

Epidemiological studies report higher prevalence rates of stress-related disorders such as acute stress disorder and post-traumatic stress disorder (PTSD) in women than in men following exposure to trauma. It is still not clear whether this greater prevalence in woman reflects a greater vulnerability to stress-related psychopathology. A number of individual and trauma-related characteristics have been hypothesized to contribute to these gender differences in physiological and psychological responses to trauma, differences in appraisal, interpretation or experience of threat, coping style or social support. In this context, the use of an animal model for PTSD to analyze some of these gender-related differences may be of particular utility. Animal models of PTSD offer the opportunity to distinguish between biological and socio-cultural factors, which so often enter the discussion about gender differences in PTSD prevalence.In this review, we present and discuss sex-differences in behavioral, neurochemical, neurobiological and pharmacological findings that we have collected from several different animal studies related to both basal conditions and stress responses. These models have used different paradigms and have elicited a range of behavioral and physiological manifestations associated with gender. The overall data presented demonstrate that male animals are significantly more vulnerable to acute and chronic stress, whereas females are far more resilient. The stark contradiction between these findings and contemporary epidemiological data regarding human subjects is worthy of further study. The examination of these gender-related differences can deepen our understanding of the risk or the pathophysiology of stress-related disorders.

Gender and PTSD: What can we learn from female police officers?

Studies of civilians typically find that female gender is a risk factor for posttraumatic stress disorder (PTSD). Police and military studies often find no gender differences in PTSD. We compared 157 female police officers and 124 female civilians on several variables including trauma exposure, peritraumatic emotional distress, current somatization, and cumulative PTSD symptoms. We found that despite greater exposure to assaultive violence in the officer group, female civilians reported significantly more severe PTSD symptoms. Elevated PTSD symptoms in female civilians were explained by significantly more intense peritraumatic emotional distress among female civilians. We also found that female officers showed a stronger direct relationship between peritraumatic emotional distress and current somatization. Our findings suggest that apparent gender differences in PTSD may result from differences in peritraumatic emotionality, which influence subsequent PTSD and somatization symptoms. Emotionality may be more important than biological sex in understanding gender differences in PTSD.

Gender Differences in PTSD in Israeli Youth Exposed to Terror Attacks

Differences between boys' and girls' exposure to terror and posttraumatic symptoms were examined in a sample of 2,999 Israeli adolescents. Gender differences were also assessed regarding perceived social support, religious beliefs, and ideological commitment. Results indicate that girls reported more posttraumatic symptoms than boys, although boys reported twice the rate of very severe symptoms. Differences were also found between boys and girls in levels of fear, religiosity, ideological commitment, and social support, but not regarding exposure. Path analysis revealed that gender is not a direct predictor of posttraumatic stress disorder (PTSD); however, it does have an indirect effect, especially through fear, which was the best predictor of PTSD. Social extrinsic religiosity and ideological intolerance were positive predictors of PTSD. The study concludes that gender differences in PTSD are largely the result of differences in levels of fear and are not due to differences in political ideology, religiosity, or social support.

Scientists Probe PTSD Effects, Treatments

San Diego—As a new generation of soldiers returns home bearing psychological scars of war, interest in and support for research on disorders such as posttraumatic stress disorder (PTSD) are high. At the Society for Neuroscience’s annual scientific meeting in November, researchers presented more than a half dozen studies probing the disorder. The studies’ findings included a biomarker that may one day help identify individuals with the disorder, enhanced explanations of how trauma may alter brain function, the discovery of intergenerational effects of trauma, and a drug that helped prevent PTSD-associated damage in rats. While many of the results are very preliminary, this recent spurt of research is a promising sign in a field that lacks validated treatment options despite a tremendous and growing demand for therapy. According to the National Institute of Mental Health, more than 5 million individuals in the United States have PTSD in any given year. A recent Institute of Medicine panel, which reviewed about 200 studies of therapies for the disorder, failed to find sufficient evidence of efficacy to recommend most of the currently used treatments (http://www.iom.edu/CMS/3793 /39330/47389.aspx). Exposure-based therapies were the only option found to have sufficient scientific support. The panel noted that many studies lacked sufficient quality to judge the effectiveness of various interventions and that there is an urgent need for high-quality trials of both pharmacological and behavioral interventions for PTSD. SEX AND GENERATIONAL EFFECTS Epidemiological studies have consistently found that PTSD is more prevalent in women than men (Olff M et al. Psychol Bull. 2007;133[2]:183-204). Rachel Yehuda, PhD, of the Traumatic Stress Studies Program at Mount Sinai School of Medicine, in New York City, discussed this and other sex-related issues in PTSD during a symposium on sex differences in stress response at the meeting. Yehuda explained that this higher prevalence may reflect women’s higher likelihood of experiencing the types of trauma that lead to PTSD, rather than greater biological vulnerability. For example, about half of individuals who have been raped develop PTSD, and women are 10 times more likely than men to be raped, she said. Sex-based differences in general stress response have been documented, and some evidence suggests there may be differences between men and women with PTSD. For instance, individuals with PTSD who have been raped tend to respond better to cognitive behavioral therapy than do combat veterans with PTSD, she said. “We need to ask whether gender differences in PTSD are simply a carryover of gender differences in stress response, or whether the actual experience and biology of PTSD is different [in men and women],” she explained. Additionally, evidence suggests that having a mother who has had PTSD may increase an individual’s risk of developing the disorder. Yehuda and her colleagues recently probed the potential biological basis of this enhanced vulnerability. The study examined cortisol levels in relation to circadian rhythms in 23 individuals who had at least 1 parent who was both a Holocaust survivor and had PTSD, 10 individuals who had at least one Holocaust survivor parent and no parent with PTSD, and 16 controls (Yehuda R et al. Arch Gen Psychiatry. 2007;64[9]:1040-1048). None of the participants themselves had PTSD. The researchers found that individuals whose mothers had PTSD were more likely to have low cortisol levels and other alter-

Gender and posttraumatic stress: Sexual violence as an explanation for women's increased risk.

Women are approximately twice as likely as men to develop posttraumatic stress disorder (PTSD), but the cause of this disparity remains unclear. This study evaluated 2 alternative explanations of gender differences in PTSD, one pointing to an intrinsic vulnerability in women and the other emphasizing sexual violence across the life span. To test these competing theories, the authors analyzed National Violence Against Women Survey data from 591 victims of partner aggression. Results suggested that gender, when considered alone, has a small but significant effect on PTSD symptom severity. However, once models factor in sexual victimization history, the latter replaces gender as a key determinant of PTSD symptoms. These findings argue against theories of "feminine vulnerability," instead linking PTSD risk to sexually violent situations.

Epidemiology of trauma, post-traumatic stress disorder (PTSD) and co-morbid disorders in Chile

In this study we examined the prevalence rates of post-traumatic stress disorder (PTSD), types of trauma most often associated with PTSD, the co-morbidity of PTSD with other lifetime psychiatric disorders, which disorders preceded PTSD, and gender differences in PTSD and trauma exposure in a representative sample of Chileans. The DSM-III-R PTSD and antisocial personality disorder modules from the Diagnostic Interview Schedule (DIS) and modules for a range of DSM-III-R diagnoses from the Composite International Diagnostic Interview (CIDI) were administered to a representative sample of 2390 persons aged 15 to over 64 years in three cities in Chile. The lifetime prevalence of PTSD was 4.4% (2.5% for men and 6.2% for women). Among persons exposed to trauma, rape was most strongly associated with PTSD. Onset of PTSD significantly increased the risk of developing each of the 10 other tested disorders. Among those exposed to trauma, women were significantly more likely to develop PTSD, after controlling for assaultive violence. This study highlights the importance of investigating the prevalence of PTSD, patterns of co-morbidity of PTSD, and gender differences in PTSD in non-English-speaking countries.

Are gender differences in post-traumatic stress disorder rates attenuated in substance use disorder patients?

Abstract We review 15 studies that examined rates of post-traumatic stress disorder (PTSD) in substance use disorder (SUD) patients to determine whether the typical female-greaterthan-male gender difference in PTSD rates is attenuated in SUD samples. Since the majority of studies reviewed did not find a gender difference in PTSD rates, we critically examined methodological factors that might account for this attenuation, but none appeared to completely account for the variability in detection of gender differences across studies. Several factors may contribute to making rates of PTSD among SUD males equivalent to the high rates observed in SUD females: 1) the risky lifestyle associated with men's substance abuse may increase their exposure to traumatic events, 2) a history of more severe trauma characteristics may be apparent among men with SUDs, or 3) attenuated gender differences in rates of other comorbidities that increase PTSD risk (e.g., depression) may exist. Clinical implications are discussed. According to epidemiological studies, post-traumatic stress disorder (PTSD) is a highly comorbid condition among those with substance use disorders (SUDs; see review by Stewart, 1996). In the National Comorbidity Survey, a large-scale epidemiologic survey conducted in the U.S., Kessler and colleagues (1997) found that those with alcohol dependence were at 3-4 times increased risk of lifetime PTSD as compared to those without alcohol dependence. Moreover, the presence of comorbid PTSD among individuals being treated for SUDs is related to poorer treatment adherence (Hien, Nunes, Rudnick Levin, & Fraser, 2000) and outcomes, including higher relapse rates (e.g., Ouimette, Brown, & Najavits, 1998; Ouimette, Finney, & Moos, 1999). It has been suggested that if patients with comorbid SUD-PTSD were to receive trauma-specific treatment, they might avoid overutilizing or misusing expensive inpatient SUD treatments, thereby reducing the cost of clinical care (e.g., Brown, Recupero, & Stout, 1995). The delineation of gender variations in the presentation of this comorbidity may identify factors that will improve treatment outcomes (Sonne et al., 2003). A fairly consistent finding across epidemiologic studies on PTSD rates in the general adult population is that women are about twice as likely to have PTSD as men (e.g., Breslau, Chilcoat, Kessler, Peterson, & Lucia, 1999; Breslau, Davis, Andreski, & Peterson, 1991; Breslau, Davis, Andreski, Peterson, & Schultz, 1997; Kessler, Sonnega, Bromet, Hughes, & Nelson, 1995). Moreover, women experience qualitatively different traumatic life experiences than do men. These findings have led to an interest in understanding gender differences in PTSD and their implications for etiology and treatment of the disorder (e.g., Kimerling, Ouimette, & Weitlauf, in press). Early research on comorbid PTSD-SUDs focused almost exclusively on male veterans whose pathology arose in the context of combat trauma; more recently, a focus has emerged on women with comorbid PTSD-SUDs (Najavits, Weiss, & Shaw, 1997). The major purpose of this article is to examine gender as an important individual difference variable with respect to trauma and PTSD among patients with SUDs. This brief review focuses on rates of trauma and PTSD among clinical samples of male and female SUD patients. Summaries of the methods and findings of the studies reviewed in this article are provided in Tables 1 and 2, for trauma exposure rates and PTSD rates, respectively. Gender Differences in Adult Samples Brown et al. (1995) studied the prevalence of trauma histories and comorbid PTSD among 84 adults (48 male; 36 female) seeking treatment at a private hospital inpatient substance-abuse treatment program. Participants completed self-report measures of lifetime trauma exposure and PTSD symptoms. Women were more likely than men to have been physically abused/assaulted (31% vs. …

Trauma exposure and post‐traumatic stress disorder in the general population

To examine the lifetime prevalence of trauma experiences and post-traumatic stress disorder (PTSD). Questionnaire-assessed PTSD, the type of traumatic event experienced, perceived trauma impact, and trauma frequency in 1824 randomly selected men and women. PTSD lifetime prevalence was estimated at 5.6% with a 1 : 2 male-to-female ratio, in spite of men reporting greater trauma exposure. The highest PTSD risk was associated with sexual and physical assault, robbery and multiple trauma experiences. Controlling for trauma type did not account for gender differences, while controlling for experienced distress did. The conditional probability for PTSD varied as a function of trauma type, frequency and impact of the event, with increased rates associated with prevalent trauma exposure and higher perceived distress. The latter accounted for the gender effect, suggesting that gender differences in PTSD in part represent a generally greater vulnerability to stress in women.