Introduction: Many of GI disorders manifest gender differences in prevalence, severity, presentation and prognosis. The aim of our study was to evaluate the impact of gender on health care utilization secondary to gastrointestinal disorders and to study time trends between 2001 and 2014.Table: Table. Demographic data comparing discharges in 2001 and 2014Methods: Using data from Nationwide Inpatient Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality, we determined the gender distribution of admissions secondary to digestive disorders (DD) (Luminal disorders; ICD 9 codes 326-395) and Pancreatohepatobiliary disorders (PHB) (ICD 9 codes 405-446). We extracted information on age, length of stay (LOS), charges, cost of hospitalization and in-hospital mortality from 2001 and 2014. Descriptive statistics, Fischer's exact test and two-sample t-test were used. Inflation was adjusted for via CPI inflation calculator. Results: Females accounted for ˜54% (DD: 54.9% and PHB: 51%) of admissions in 2014. Between 2001 and 2014 there was a decrease in proportion of females admitted but this trend was more pronounced in patients with PHB disorders (56.5% to 50.9%; p < 0.05). Females admitted with DD were significantly older than males (mean age: 59.5 yr vs. 55.5yr) (p < 0.05). Mean age of female admitted with DD disorders remained stable but decreased from 54.7 yrs to 53.7 yrs in patients with PHB issues. LOS for females admitted with PHB and DD significantly decreased (p < 0.05). For patients admitted with DD, charges and cost for males increased to greater than females. However, charges and costs increased to greater extent in females admitted with PHB disorders when compared to male counterparts. Inpatient mortality decreased significantly in females compared to males when examining DD and PHB disorders. (p < 0.05). Conclusion: Our study showed decreasing proportion of females admitted with gastrointestinal disorders. Length of stay and inpatient mortality decreased overtime. Between luminal and hepatopancreatobiliary disease we saw gender based difference in age of presentation and resource utilization. Changing social values, healthcare seeking behavior and disease pathophysiology might have contributed to these changes.