Role Of Sex Research Articles

Exploring the role of sex in the association of late chronotype on cardiorespiratory fitness.

Circadian rhythms differ between young adult males and females. For example, males tend to be later chronotypes, preferring later timing of sleep and activity, than females. Likewise, there are sex differences in body composition and cardiorespiratory fitness. Few studies have investigated the association between circadian rhythms, cardiorespiratory fitness, and body composition. We sought to determine whether chronotype and circadian phase were associated with cardiorespiratory fitness, body composition, and anthropometric measures in sedentary males and females. Fifty-nine adults participated in the study. Circadian phase and chronotype were measured using dim light melatonin onset (DLMO) and the Morningness-Eveningness Questionnaire (MEQ) score. We used peak oxygen uptake (VO2peak ) results from a maximal graded exercise test to assess cardiorespiratory fitness. Body composition, BMI, and circumferences were collected as markers of adiposity. We observed a sex difference in the association between DLMO and VO2peak . For males, a later DLMO was associated with a lower VO2peak . VO2peak did not vary based on DLMO in females. Later circadian phase was also associated with increased body fat percentage, fat mass index, and abdominal circumference in males, but not females. Collectively, these results suggest that males who are later chronotypes may be at risk of obesity and low cardiorespiratory fitness.

Sibling and peer bullying victimization in adolescence: Masculinity, femininity, and the moderating role of sex and popularity.

We investigated whether gender-typed traits (masculinity and femininity) contemporaneously predicted self-reported peer victimization, peer-reported peer victimization, and sibling victimization. We also tested the moderating role of sex and popularity. A sample of 2782 British pupils aged 11-16 from Central England, UK was screened for bullying involvement and popularity using self-report and peer nominations, and a subsample of 704 (52.7% girls) completed a measure of gender-typed traits (masculinity and femininity). Hierarchical multiple regression analyses revealed that low levels of masculine traits were associated with greater risk of self-reported peer victimization, there were no associations with peer-reported peer victimization, and low levels of feminine traits were associated with greater risk of self-reported sibling victimization. The effects were not moderated by sex, while popularity decreased the risk of self- and peer-reported peer victimization. Bullying prevention interventions could benefit from including the positive facets of feminine and masculine traits.

Confirmation of COVID-19 infection status and reporting of Long COVID symptoms in a population-based birth cohort: No evidence of a nocebo effect.

Some patients with COVID-19 develop symptoms after the acute infection, known as 'Long COVID'. We examined whether or not confirmation of COVID-19 infection status could act as a nocebo, using data from questionnaires distributed to the Avon Longitudinal Study of Parents and Children cohort. We examined associations between confirmation of COVID-19 infection status (confirmed by a positive test vs unconfirmed) and reporting of Long COVID symptoms. We explored the roles of sex and anxiety as potential moderators. There was no clear evidence of a strong association between confirmation of COVID-19 infection status and the Long COVID composite score, physical or psychological symptoms or duration of symptoms. There was no clear evidence of moderation by sex or anxiety. We therefore found no evidence of a nocebo effect. Our data suggest that this psychological mechanism does not play a role in the medical symptomatology experienced by patients with Long COVID.

Translatability of mouse muscle-aging for humans: the role of sex

Muscle-aging drives sarcopenia and is a major public health issue. Mice are frequently used as a model for human muscle-aging, however, research investigating their translational value is limited. In addition, mechanisms underlying muscle-aging may have sex-specific features in humans, but it is not yet assessed whether these are recapitulated in mice. Here, we studied the effects of aging on a functional, histological and transcriptional level at multiple timepoints in male and female mice (4, 17, 21 and 25 months), with particular emphasis on sex-differences. The effects of natural aging on the transcriptome of quadriceps muscle were compared to humans on pathway level. Significant loss of muscle mass occurred late, at 25 months, in both male (-17%, quadriceps) and female mice (-10%, quadriceps) compared to young control mice. Concomitantly, we found in female, but not male mice, a slower movement speed in the aged groups compared to the young mice (P < 0.001). Consistently, weighted gene co-expression network analysis revealed a stronger association between the aging-related reduction of movement and aging-related changes in muscle transcriptome of female compared to male mice (P < 0.001). In male, but not female mice, major distinctive aging-related changes occurred in the last age group (25 months), which highlights the necessity for careful selection of age using mice as a muscle-aging model. Furthermore, contrasting to humans, more aging-related changes were found in the muscle transcriptome of male mice compared to female mice (4090 vs. 2285 differentially expressed genes at 25 months, respectively). Subsequently, male mice recapitulated more muscle-aging related pathways characteristic for both male and female humans. In conclusion, our data show that sex has a critical effect on the mouse muscle-aging trajectory, although these do not necessarily reflect sex differences observed in the human muscle-aging trajectory.

P1105 Short-term exposure to environmental air pollution and inflammatory bowel disease flares: a time-stratified case cross-over study

Abstract Background Some epidemiological studies suggest that long-term exposure to environmental air pollutants, such as particulate matter (PM), could have a role in inflammatory bowel disease (IBD) incidence and pathogenesis. However, less is known about the potential effect of short-term air pollution exposure. The aim of this study is to investigate whether short-term exposure to environmental air pollution is associated with the occurrence of IBD flares. Methods Anonymized hospital discharge records (HDR) with ICD-9-CM codes 555 (Crohn’s disease) and 556 (ulcerative colitis) for years 2002-2009 from all hospitals of the Lombardy region were collected. All HDR of adult patients (18-75 years) resident in Milan were included, except for recurrent hospitalizations within 6 months. Each record was assigned daily PM ≤10 µm (PM10) concentrations at municipality level by averaging PM10 levels of the day of admission with the levels of the day before (lag01) and of each preceding day up to six days before (lag06). To evaluate the association between PM10 and IBD-related hospitalizations, a time-stratified case-crossover study design was applied. Conditional logistic regression models, calculating Odds Ratios (OR) and 95% Confidence Intervals (95%CI) per increments of 10 µg/m3 of PM10, were performed. Results Overall, 2,176 hospital admissions (males=1,137, Crohn’s disease=1,264, ulcerative colitis=912) were included. In the entire population no clear association between PM10 and IBD-related hospitalization was identified, notwithstanding a small risk increase for males (OR: 1.03; 95%CI: 0.99-1.08 at lag04). When further stratifying for ICD code, an increased risk of hospitalization for "left-sided ulcerative colitis" (ICD code: 556.5) was found in males only, for exposures in all days preceding hospitalization up to lag04 (1.28; 1.05-1.28; 59 cases, 207 controls) (Figure 1). In females, the association was weaker, although positive (1.14; 0.91-1.42; 49 cases, 164 controls). No relevant findings emerged when looking at other ICD codes. Conclusion We observed an increased risk of IBD-related hospitalization in male patients with left-sided ulcerative colitis per increasing levels of air pollution in the days preceding hospital admission. Although preliminary, our findings suggest the possible role of sex as an effect modifier of the influence that air pollution might exert on IBD flares. Further studies are needed to better comprehend the complex framework characterizing the interplay between environmental and individual factors contributing to IBD.

Achalasia alters physiological networks depending on sex

Achalasia is a rare esophageal motility disorder for which the etiology is not fully understood. Evidence suggests that autoimmune inflammatory infiltrates, possibly triggered by a viral infection, may lead to a degeneration of neurons within the myenteric plexus. While the infection is eventually resolved, genetically susceptible individuals may still be at risk of developing achalasia. This study aimed to determine whether immunological and physiological networks differ between male and female patients with achalasia. This cross-sectional study included 189 preoperative achalasia patients and 500 healthy blood donor volunteers. Demographic, clinical, laboratory, immunological, and tissue biomarkers were collected. Male and female participants were evaluated separately to determine the role of sex. Correlation matrices were constructed using bivariate relationships to generate complex inferential networks. These matrices were filtered based on their statistical significance to identify the most relevant relationships between variables. Network topology and node centrality were calculated using tools available in the R programming language. Previous occurrences of chickenpox, measles, and mumps infections have been proposed as potential risk factors for achalasia, with a stronger association observed in females. Principal component analysis (PCA) identified IL-22, Th2, and regulatory B lymphocytes as key variables contributing to the disease. The physiological network topology has the potential to inform whether a localized injury or illness is likely to produce systemic consequences and the resulting clinical presentation. Here we show that immunological involvement in achalasia appears localized in men because of their highly modular physiological network. In contrast, in women the disease becomes systemic because of their robust network with a larger number of inter-cluster linkages.

Empowering the Next Generation: Unveiling Leadership Motivators for Millennial Women in Christian Higher Education

Over the past decade, the rate of presidential turnover in higher education has accelerated, prompting research on what motivates the next generation of leaders. This article focuses on millennial women in Christian higher education, a sector where White male leaders have historically dominated: Women have remained underrepresented in college presidencies despite earning the majority of degrees at all levels. Although leadership literature has addressed that women have broken beyond the glass ceiling toward improved gender equity, both gender and generational barriers continue to impede a woman’s ambition to pursue a presidency. The research herein was conducted using the theoretical framework by Dahlvig and Longman, a women’s leadership development model, to investigate further millennial women’s intrinsic and extrinsic motivators to aspire and pursue a presidency in Christian higher education. This article explores the relevant literature and examines the findings from interviews of 12 millennial women participants who work at Christian colleges and universities within the Council for Christian Colleges & Universities. Seven major themes emerged from the data: (a) patient preparation for the presidency; (b) the value of relationships, recognition, and representation; (c) how the experiences of current leaders differ; (d) what it means to be intrinsically wired as a leader; (e) care for the well-being of the institution; (f) exercising faith over fear; and (g) transformation through developmental relationships with mentors, coaches, and sponsors. These findings contribute to an understanding of the motivators of millennial women as they contrast with previous generations. Findings also support the adapted model proposed here, the millennial women’s leadership development model, as well as offering practical implications for campus leaders and aspiring women presidents.

School belonging and depressive symptoms: the mediating roles of social inclusion and loneliness

Background Loneliness and depressive symptoms are prevalent among Finns. Objectives This study, which analyzes nationwide data from 149,986 students aged 13–18 years in Finland, focuses on the mediating effects of social inclusion and loneliness in the association between school belonging and depressive symptoms. Method and results The analysis of variance showed that boys reported higher levels of school belonging and social inclusion, whereas girls reported higher levels of loneliness and depressive symptoms. Mediation analysis showed that social inclusion and loneliness partially mediated the effect of school belonging on depressive symptoms, but that social inclusion’s effect was much greater than loneliness’s. By focusing on the moderating role of sex, it was discovered that social inclusion significantly mediated depressive symptoms in girls more than boys. Conclusion The importance of social inclusion in preventing depressive symptoms was highlighted in the discussion.

Unhiding the voices of women in the Parable of the Good Samaritan: A call for academic inclusion

The parables of Jesus are often susceptible to patriarchal, androcentric interpretations. By using a realistic reading and social-scientific criticism, this article will investigate the voices, roles, and presence of women in the parable of the Good Samaritan, and how the 1st-century audience of the parable would most likely have understood women to be present, even if not mentioned in the parable. Women played critical roles in terms of hospitality, travel, innkeeping, and healing. These roles and voices of women are often ignored by modern interpreters and exegetes. This article not only emphasises the valuable roles that women fulfilled in the time of Jesus but also critiques the lack, or absence, of women as a point of discussion, acknowledgement, and study in most biblical commentaries and books concerning the parable of the Good Samaritan. The aim of this research is to contribute to the unhiding of women voices in patriarchal, androcentric texts thereby reconstructing and deconstructing gender paradigms within biblical scholarship.Intradisciplinary and/or interdisciplinary implications: The interdisciplinary nature of this article contributes to the debate on the roles and importance of women in the church by investigating the value that women had in the parables of Jesus. By reading women as present in the text, emphasis is given to the voices of women in the Bible and the importance of their representation today. This research is also in line with the United Nations (UN) Sustainable Development Goal (SDG) 5: Gender equality and women empowerment.

Unveiling the Language of Expression: Decoding Verbal and Non-verbal Cues in English Literature

This qualitative content analysis decodes the complex interplay of verbal and non-verbal cues in Mohsin Hamid's Exit West. Focused on characters Saeed and Nadia, the study reveals nuanced power dynamics and challenges to traditional gendered communication norms. Examining instances of conformity and resistance to gendered communication ideals, the analysis sheds light on emotional intelligence and societal negotiation. The study not only enhances understanding of character dynamics but contributes to broader discussions in literary, cultural, and gender studies. Additionally, this research invites further exploration into the evolving nature of communication in contemporary literature.

Sex-specific resting state brain network dynamics in patients with major depressive disorder.

Sex-specific neurobiological changes have been implicated in Major Depressive Disorder (MDD). Dysfunctions of the default mode network (DMN), salience network (SN) and frontoparietal network (FPN) are critical neural characteristics of MDD, however, the potential moderating role of sex on resting-state network dynamics in MDD has not been sufficiently evaluated. Thus, resting-state functional magnetic resonance imaging (fMRI) data were collected from 138 unmedicated patients with first-episode MDD (55 males) and 243 healthy controls (HCs; 106 males). Recurring functional network co-activation patterns (CAPs) were extracted, and time spent in each CAP (the total amount of volumes associated to a CAP), persistence (the average number of consecutive volumes linked to a CAP), and transitions across CAPs involving the SN, DMN and FPN were quantified. Relative to HCs, MDD patients exhibited greater persistence in a CAP involving activation of the DMN and deactivation of the FPN (DMN + FPN-). In addition, relative to the sex-matched HCs, the male MDD group spent more time in two CAPs involving the SN and DMN (i.e., DMN + SN- and DMN-SN + ) and transitioned more frequently from the DMN + FPN- CAP to the DMN + SN- CAP relative to the male HC group. Conversely, the female MDD group showed less persistence in the DMN + SN- CAP relative to the female HC group. Our findings highlight that the imbalance between SN and DMN could be a neurobiological marker supporting sex differences in MDD. Moreover, the dominance of the DMN accompanied by the deactivation of the FPN could be a sex-independent neurobiological correlate related to depression.

Sexual dimorphism in cortical theta rhythms relates to elevated internalizing symptoms during adolescence

Abstract Psychiatric disorders frequently emerge during adolescence, with girls at nearly twice the risk compared to boys. These sex differences have been linked to structural brain differences in association regions, which undergo profound development during childhood and adolescence. However, the relationship between functional activity in these cortical regions and the emergence of psychiatric disorders more broadly remains poorly understood. Herein, we investigated whether differences in internalizing and externalizing symptoms among youth are related to multispectral spontaneous neural activity. Spontaneous cortical activity was recorded using magnetoencephalography (MEG) in 105 typically-developing youth (9-15 years-old; 54 female) during eyes-closed rest. The strength of spontaneous neural activity within canonical frequency bands was estimated at each cortical vertex. The resulting functional maps were submitted to vertex-wise regressions to identify spatially specific effects whereby sex moderated the relationship between externalizing and internalizing symptoms, age, and spontaneous neural activity. The interaction between sex, age, and internalizing symptoms was significant in the theta frequency band, wherein theta activity was weaker for older relative to younger girls (but not boys) with greater internalizing symptoms. This relationship was strongest in the temporoparietal junction, with areas of the cingulate cortex exhibiting a similar relationship. The moderating role of sex in the relationship between age, internalizing symptoms, and spontaneous theta activity predominantly implicated association cortices. The negative relationship between theta and internalizing symptoms may reflect negative rumination with anxiety and depression. The specificity of this effect to older girls may reflect the selective emergence of psychiatric symptoms during adolescence in this subgroup.

Factors associated with disease control failure in acromegaly patients treated with pegvisomant: an ACROSTUDY analysis.

The aim of this study was to examine the probability of achieving acromegaly disease control according to several patient-, disease- and treatment-related factors longitudinally. We analyzed data from ACROSTUDY, an open-label, noninterventional, post-marketing safety surveillance study conducted in 15 countries. A total of 1546 patients with acromegaly and treated with pegvisomant, with available information on baseline IGF-1 level, were included. Factors influencing IGF-1 control were assessed up to 10 years of follow-up by mixed-effects logistic regression models, taking into account changing values of covariates at baseline and at yearly visits. Twenty-eight anthropometric, clinical and treatment-related covariates were examined through univariate and multivariate analyses. We tested whether the probability of non-control was different than 0.50 (50%) by computing effect sizes (ES) and the corresponding 95% CI. Univariate analysis showed that age <40 years, normal or overweight, baseline IGF-1 <300 µg/L or ranged between 300 and 500 µg/L, and all pegvisomant dose <20 mg/day were associated with a lower probability of acromegaly uncontrol. Consistently, in multivariate analyses, the probability of uncontrolled acromegaly was influenced by baseline IGF-1 value: patients with IGF-1 <300 µg/L had the lowest risk of un-controlled acromegaly (ES = 0.29, 95% CI: 0.23-0.36). The probability of acromegaly uncontrol was also lower for values 300-500 µg/L (ES = 0.37, 95% CI: 0.32-0.43), while it was higher for baseline IGF-1 values ≥700 µg/L (ES = 0.58, 95% CI: 0.53-0.64). Baseline IGF-l levels were a good predictor factor for long-term acromegaly control. On the contrary, our data did not support a role of age, sex, BMI and pegvisomant dose as predictors of long-term control of acromegaly. Among factors that could influence and predict the efficacy of pegvisomant therapy in controlling acromegaly, a central role of baseline IGF-1 values on the probability of achieving a biochemical control of acromegaly during the treatment with pegvisomant was identified, in a real-life setting.

Gender and access to Inclusive Education in Tanzania: A Case of Selected Primary Schools in Shinyanga and Mwanza Regions

This study examined gender relations and access to inclusive education for children with disabilities in Shinyanga and Mwanza regions. The study was conducted specifically to examine community attitudes and practices towards girls with disabilities, harmful gender cultural norms, practices, traditions and barriers girls with disabilities face in accessing education. The study employed interpretive phenomenological design and purposive sampling technique to obtain 96 participants. Children with disabilities were identified by using the Child Functioning Module (CFM) questions and participants were purposively sampled. Data were collected using key informant interviews, focus group discussions and observations. Thematic analysis techniques were employed to analyse the data. The study found that there were deep rooted discriminatory cultural practices and gender norms which rendered children with disabilities excluded from school as compared to their male peers and those without disabilities. This was further compounded by poor teaching and learning environment. Girls faced greater barriers than boys, including more hours spent doing household chores, early marriages and pregnancies leading to drop out. It is recommended for government, community and development partners to focus more on children with disabilities, especially girls, increase community awareness on inclusive education and gender as well as improve teaching and learning environments.

Gut microbiota variations in wild yellow baboons (Papio cynocephalus) are associated with sex and habitat disturbance

Although male and female mammals differ in biological traits and functional needs, the contribution of this sexual dimorphism to variations in gut bacteria and fungi (gut microbiota) in relation to habitat type has not been fully examined. To understand whether the combination of sex and habitat affects gut microbiota variation, we analyzed 40 fecal samples of wild yellow baboons (Papio cynocephalus) living in contrasting habitat types (intact, well-protected vs. fragmented, less protected forests) in the Udzungwa Mountains of Tanzania. Sex determination was performed using the marker genes SRY (Sex-determining Region Y) and DDX3X-DDX3Y (DEAD-Box Helicase 3). Samples were attributed to 34 individuals (19 females and 15 males) belonging to five social groups. Combining the results of sex determination with two amplicon sequencing datasets on bacterial (V1–V3 region of the 16S rRNA gene) and fungal (ITS2) gut communities, we found that overall, baboon females had a significantly higher gut bacterial richness compared to males. Beta diversity estimates indicated that bacterial composition was significantly different between males and females, and this was true for individuals from both well- and less protected forests. Our results highlight the combined role of sex and habitat type in shaping variation in gut microbial communities in wild non-human primates.

Personal and family factors for emotional distress in adolescents with chronic disease.

Physical and psychological comorbidity is a challenge for public health, especially in the adolescent stage due to the difficulties of this age. The salutogenic perspective emphasizes general psychological resources such as self-esteem but also highlights the role of contextual factors such as family members in promoting health. From this perspective, the objective of this study was to analyze the joint influence of demographic factors (sex, age and type of chronic disease), personal factors (self-esteem and perception of threat of the disease) and family factors (affection and communication, psychological and behavioral control) of risk of emotional distress (anxiety-depressive symptoms) in chronically ill adolescents. The study is a cross-sectional design with 495 adolescents with chronic disease aged 12-16 years. In order to obtain the results, a linear methodology was used to compare means and perform regressions to predict belonging to the anxiety and depression typologies. Four typologies were constructed: typology I (high anxiety and depression scores); typology II (high anxiety and low depression scores); typology III (low anxiety and high depression scores) and typology IV (low anxiety and depression scores). The results were consistent with the salutugenic theory. Potential mediating or moderating roles of age, sex, self-esteem, perceived threat and psychological and behavioral control marked the differences between the typologies. This population could benefit from interventions focused on family flexibility.

Exploring social touch in autistic and non-autistic adults via a self-report body-painting task: The role of sex, social context and body area.

What is already known about the topic?At least in neurotypical individuals, social touch represents an important channel for emotional communication associated with social bonding and pain/anxiety modulation. Autistic adults report to avoid social touch more and to have different tactile sensitivity than their non-autistic comparisons.What this paper adds?Few studies specifically investigated social touch in autistic individuals, and none of them examined the role of participants' sex, social context in which social touch occurs, and specific body areas being touched. In our study, adult participants reported how pleasant, erogenous and appropriate they would consider touches delivered by another person over their entire body in intimate (date), friendly (dance class) and professional (physiotherapy-massage session) social contexts. Autistic adults reported social touch to be less pleasant, erogenous and appropriate specifically in intimate and friendly social contexts and in body areas typically touched in these situations. Importantly, autistic females seem more at risk to experience unpleasant social touch as, although they considered it more unpleasant than non-autistic females and autistic males, they did consider it similarly appropriate in professional social contexts where touch is normed to be socially appropriate.Implications for practice, research or policyOur results might improve awareness and understanding about autistic adults' different, and often more discomforting, experience of social touch and thus help consider and respect it during everyday social interactions. Our results might also benefit future research investigating, for instance, the neural underpinnings of social touch differences in autism or aiming at developing support for autistic individuals seeking help in the diverse spheres of social touch.

Couple dominance, dark personality traits, and power motivation

In romantic couples, there is usually an asymmetry in decisional power such that one partner is dominant and the other is subordinate. This study investigated the role of sex, ethnicity, self-assessed social status, personality traits, and power motivation (both explicit and implicit) as potential determinants or correlates of couple dominance in a mixed-sex sample of 50 college students. Through a previously validated questionnaire, participants indicated whether they were dominant or subordinate in their romantic relationship, or whether the latter was egalitarian. Major personality domains, narcissism, psychopathy, borderline, autistic-like traits, and explicit power were assessed through questionnaires. Participants also underwent a Picture Story Exercise to evaluate their implicit motives. Being dominant and having high explicit, but not implicit, power motivation were associated with some psychopathic, narcissistic, and/or borderline traits, while autistic-like traits were associated with being subordinate. Traits such as extraversion, conscientiousness, and honesty-humility had weak associations with couple dominance and/or explicit or implicit power motivation. Our findings have implications for the understanding of dominance dynamics within couples and the relationship between personality traits and power motivation.

Peer victimization and non-suicidal self-injury among high school students: the mediating role of social anxiety, mobile phone addiction, and sex differences

BackgroundPeer victimization (PV) is one of the major causes of non-suicidal self-injury. Non-suicidal self-injury (NSSI), peer victimization, social anxiety, and mobile phone addiction are significantly related; however, the interaction mechanism and effect of sex differences remain to be determined.ObjectiveHerein, we investigated the relationship between peer victimization and NSSI among Chinese high school students. We also explored the chain mediating roles of social anxiety and mobile phone addiction and the regulatory role of sex. The findings of this study provide insights for theoretical interventions based on internal mechanisms.MethodA self-reported survey of 14,666 high school students from Sichuan County was conducted using a peer victimization scale, NSSI scale, social anxiety scale, and mobile phone addiction scale. A self-administered questionnaire was used to capture sociodemographic information.ResultsPeer victimization, social anxiety, and mobile phone addiction were positively correlated with NSSI. Peer victimization had significant direct predictive effects on NSSI (95% CI: 0.341, 0.385) and significant indirect predictive effects on NSSI through social anxiety (95% CI: 0.008, 0.019) or mobile phone addiction (95% CI: 0.036, 0.053). Peer victimization had significant indirect predictive effects on NSSI through social anxiety as well as mobile phone addiction (95% CI: 0.009, 0.014). The first stage (predicting the effect of peer victimization on NSSI) and the third stage (predicting the effect of mobile phone addiction on NSSI) were both moderated by sex.ConclusionsPeer victimization could directly predict NSSI and indirectly predict NSSI through social anxiety and mobile phone addiction. Thus, social anxiety and mobile phone addiction exhibited chain mediating effects between peer victimization and NSSI in high school students; moreover, sex might be involved in the regulation of the mediation process.

Pharmacological Treatments for Alcohol Use Disorder: Considering the Role of Sex and Gender

Pharmacological Treatments for Alcohol Use Disorder: Considering the Role of Sex and Gender