To control the seismic response of the core-frame (CF) structure and attenuate the stress level of the core tube, a novel core-damper-frame (CDF) system is proposed by decoupling the perimeter frame and the central core with flexible damper connectors. In this way, the large inertia force of the perimeter frame cannot be fully transmitted to the core, and the stress of the core is mitigated. In the meantime, the damper connectors would absorb a considerable amount of seismic energy, protecting the perimeter frame as the relative displacement between the two subsystems (perimeter frame and core tube) occurs. By incorporating the soil-structure-interaction (SSI) and the filtered Gaussian white-noise excitation model, the "excitation-soil-core-damper-frame" augmented system is established. Combing the augmented system and the genetic algorithm, a stochastic optimization procedure of the CDF considering the SSI effect is proposed. The optimization aims to minimize a series of performance objectives including displacement, acceleration, shear force, and overturning moment of the CDF system. The conflicting relationships between the multiple objectives are discussed; the influence of the SSI effect and the excitation parameters are evaluated. From an illustrative 40-story CDF structural example, the system shows great superiority in controlling the higher mode vibrations, and could significantly reduce the peak core acceleration (by 54.44 %), frame acceleration (by 56.48 %), core drift (by 28.83 %), frame drift (by 39.28 %), core shear (by 83.67 %), and frame moment (by 22.41 %), as compared to its conventional CF counterpart. In special, over 50 % of the input seismic energy is dissipated by the damper connectors in the CDF system.
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