Event Abstract Back to Event Beyond linear perturbation theory: the instantaneous response of the integrate-and-fire model Moritz Helias1*, Moritz Deger2, Stefan Rotter2 and Markus Diesmann1 1 RIKEN Brain Science Institute, Japan 2 Bernstein Center for Computational Neuroscience, Germany The integrate-and-fire neuron model with exponential postsynaptic potentials is widely used in analytical work and in simulation studies of neural networks alike. For Gaussian white noise input currents, the membrane potential distribution is known exactly [1]. The linear response properties of the model have successfully been calculated and applied to the dynamics of recurrent networks in this diffusion limit [2]. However, the diffusion approximation assumes the effect of each synapse on the membrane potential to be infinitesimally small. Here we present a novel hybrid theory that takes finite synaptic weights into account. We show, that this considerably alters the absorbing boundary condition at the threshold: the probability density increases just below threshold. As a result, the response of the neuron to a fast transient input is enhanced much in the same way as found for the case of synaptic filtering [3]. However, in contrast to this earlier work relying on linear perturbation theory [4], we quantify to all orders an instantaneous response that is asymmetric for excitatory and inhibitory transients and exhibits a non-linear dependence on positive perturbation amplitudes. Furthermore we demonstrate that in the pooled response of two neuronal populations to antisymmetric transients the linear components exactly cancel. In this scenario the macroscopic network dynamics is dominated by the instantaneous non-linear components of the response. These results suggest that the linear response approach neglects important features of the rectifying nature of threshold units with finite jumps even for small perturbations. We provide an analytical framework to go beyond [5]. Partially funded by BMBF Grant 01GQ0420 to BCCN Freiburg, EU Grant 15879 (FACETS), DIP F1.2, Helmholtz Alliance on Systems Biology, and Next-Generation Supercomputer Project of MEXT.
Read full abstract