As neutral carriers for soduim ion-sensitive field-effect transistors (ISFETs), unsymmetrical calix[4]arene ionophores have been designed which possess three ester linkages and an amide linkage as the cation-binding sites. One of the calix[4]arene derivative are highly soluble in silicone rubber, which is very adhesive to inorganic FET gates, thus affording stable sensing membranes for the ISFET. The resulting sodium ISFETs based on the calixarene ionophore/silicone rubber composities showed high sodium ion selectivity and high sensor durability