Gastrointestinal Polyps Research Articles

Unusual manifestations of Peutz-Jegher's syndrome in children

PeutzJegher's syndrome (PJS) is a rare, autosomal dominant disease, characterized by gastrointestinal (GI) polyps and perioral hyperpigmentation along with the increased risk of certain malignancies. In children, the most common presentation is recurrent intussusception due to polyps. These polyps can involve any part of the GI tract and can present with a variety of clinical presentations. Usually, these polyps can be removed endoscopically but often require surgical excision also. In this report, we discuss two children of PJS with uncommon presentations, one presented with retrograde intussusception and another with gastric outlet obstruction. The first child underwent laparoscopy and another required open surgery with intraoperative enteroscopy.

High Grade Dysplastic Villous Adenoma Arising from a Giant Hamartomatous Polyp- A Rare Case Presentation

Adenomatous polyps can be found throughout the colon, most commonly in right colon. Microscopically they are classified as tubular, villous or tubulovillous subtypes. Tubular adenomas are the most common subtype with villous component less than 25%. Tubulovillous adenomas have a villous component that accounts for 25-75%, while villous adenomas have a villous component that accounts for more than 75% of the polyp. Peutz-Jeghers syndrome which is an autosomal dominant condition is characterised by gastrointestinal hamartomatous polyp with distinctive arborization of smooth muscle within the lamina propria. Peutz-Jeghers type polyp is a hamartomatous polyp without associated mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome. In the present case study, a 82-year-old male presented with the chief complaint of constipation and abdominal distension since six months. A polypoidal rectal growth was identified on sigmoidoscopy. The clinical diagnosis of mid rectal growth with acute colonic obstruction was made. Positron Emission Tomography and Computed Tomography (PET CT) was done which was suggestive of malignancy and therefore, Hartmann’s procedure was performed and lesion was excised. On gross examination, a portion of large intestine including sigmoid colon and rectum was received and a pedunculated polypoidal lesion measuring 4.5×3.5×3 cm along with stalk measuring 2.5 cm was seen. On microscopy, the polyp with extensive arborization of muscularis mucosa into the lamina propria was seen with one area showing features of villous adenoma with high-grade dysplasia. Hence, a final diagnosis was given as villous adenoma with high grade dysplasia arising from a hamartomatous polyp consistent with Peutz-Jeghers polyp. The identification of a villous adenoma with high-grade dysplasia in a Peutz-Jegher type polyp is essential in such situations since it is a precursor of invasive malignancy

Dual U-Net with Resnet Encoder for Segmentation of Medical Images

Segmentation of medical images has been the most demanding and growing area currently for analysis of medical images. Segmentation of polyp images is a huge challenge because of the variability of color depth and morphology in polyps throughout colonoscopy imaging. For segmentation, in this work, we have used a dataset of images of the gastrointestinal polyp. The algorithms used in this paper for segmentation of gastrointestinal polyp images depend on profound deep convolutional neural network architectures: FCN, Dual U-net with Resnet Encoder, U-net, and Unet_Resnet. To improve the performance, data augmentation is performed on the dataset. The efficiency of the algorithms is measured by using metrics such as Dice Similarity Coefficient (DSC) and Intersection Over Union (IOU). The algorithm Dual U-net with Resnet Encoder obtains a higher DSC of 0.87 and IOU of 0.80 and beats the other algorithms U-net, FCN, and Unet_Resnet in segmentation of gastrointestinal polyp images.

Heterotopic Bone Formation in Juvenile Polyp: A Histopathological Entity.

CASE REPORT A 5-year-old boy presented with a 1-month history of blood in stools. The blood was bright red in color, moderate in amount, and associated with intermittent abdominal pain. He had no history of pain during defecation, no constipation, and no alteration in frequency or consistency of stool. Systemic examination revealed only pallor. Local examination of the boy was unremarkable. Colonoscopy examination revealed terminal ileitis with a rectal polyp (Figure 1). A polypectomy was performed, and a specimen was sent for histopathological examination. Grossly, a polypoidal tissue cut section measuring 1.0 × 0.5 × 0.3 cm was firm and greyish white. Microscopic examination showed a polyp with mucosal surface ulceration. Numerous cystically dilated and tortuous crypts filled with inspissated mucin were seen. Intervening lamina propria was edematous and filled with mixed inflammatory cells. One focus showed bony trabeculae rimmed by osteoblast. We diagnosed our patient with juvenile polyp with osseous metaplasia.Figure 1.: Colonoscopy showing polyp in the rectum.Figure 2.: Hematoxylin-eosin stain, ×40 magnification. Juvenile polyp having surface ulceration, and a single black arrow showing osseous metaplasia.Figure 3.: Hematoxylin-eosin stain, ×200 magnification. Juvenile polyp, a single black arrow showing bony matrix, and a single blue arrow showing osteocytes in lacunae.Juvenile polyps are hamartomatous polyps which may undergo osseous metaplasia. In most recent studies, expression of bone (Figures 2 and 3) morphogenic proteins had been observed in the setting of osseous metaplasia.1 Osseous metaplasia, ie, heterotopic bone formation, is an adaptive response to any chronic inflammation. Only a few cases of neoplastic and nonneoplastic gastrointestinal polyps are associated with this extremely rare type of metaplasia.2 It is most commonly seen in the colorectal region in association with epithelial polyps. To the best of our knowledge, only 9 other cases of osseous metaplasia in juvenile polyps have been reported so far worldwide.2 DISCLOSURES Author contributions: M. Mohanty edited the article, reviewed the literature, provided images, and is the article guarantor. N. Pandey wrote the article and reviewed the literature. U. Senapati revised and approved final the article. P. Nath provided images and revised and approved the final article. Acknowledgments: We thank technician Niskara Sahoo for their contribution in good section cutting. Financial disclosure: None to report. Informed consent was obtained for this case report.

GASTROINTESTINAL POLYPS IN DUHOK-IRAQ. A PRACTICAL HISTOPATHOLOGICAL STUDY

Background: To identify the frequency and types of gastrointestinal polyps in Duhok central and private laboratories.

Effect of High Quality Nursing on Negative Emotion and Satisfaction of Gastrointestinal Polyps Treated by Digestive Endoscopy

Effect of High Quality Nursing on Negative Emotion and Satisfaction of Gastrointestinal Polyps Treated by Digestive Endoscopy

S1681 Malignant Peritoneal Mesothelioma (PeM) With Rhabdoid Features Masquerading as Idiopathic Necrotizing Pancreatitis With Mucinous Ascites: A Case Report and Literature Review

Introduction: Malignant Mesothelioma (MM) is a great masquerader, presenting as infection, metastasis, other cancers or as a paraneoplastic syndrome. Malignant peritoneal mesothelioma (PeM) accounts for about 10-15% of all cases of mesothelioma. MM presenting with malignant gastrointestinal (GI) polyps is also rare, with only 16 reported cases of mesothelioma presenting as metastatic disease in the GI tract. Here, we present the clinicopathologic findings of a case of a malignant peritoneal rhabdoid mesothelioma presenting as a necrotizing pancreatic mass, recurrent deep vein thrombosis (DVT), chylous ascites, and late onset weight loss. Case Description/Methods: A 76-year-old female initially presenting with idiopathic necrotizing pancreatitis. She continued to report persistent vague lower and mid abdominal pain. Six months after her initial admission the patient developed a DVT and pulmonary embolism (PE) requiring thrombectomy and anticoagulation with a recurrent DVT requiring IVC filter placement. She continued to have recurrent ascites and an enlarging peripancreatic fluid collection. Multiple paracenteses were performed with studies negative for infection and cytology negative for malignancy; however, most samples could not be analyzed due to fluid viscosity. An endoscopic retrograde cholangiopancreatography was performed with pancreatic and biliary stents placed. Almost one year after the patient’s initial admission, cross-sectional abdominal imaging showed omental caking with enlargement of the proximal pancreas. An endoscopic ultrasound with fine needle aspiration was performed was non-diagnostic. Lymphangiogram performed chylous nature of ascites. MRI showed a large fluid volume surrounding the pancreas and extended into the pararenal spaces. There was a mass effect leading to displacement of the surrounding structures. Diagnostic laparoscopy showed abdominal wall and peritoneal implants in addition to a large, firm, and highly vascularized epigastric mass. Pathology showed peritoneal mesothelioma. Discussion: We have presented a case of PeM with rhabdoid features present in the peritoneum and in gastric polyps. PeMs are rare tumors with a non-specific clinical presentation. These lesions are also difficult to diagnose and definitive diagnosis of MPM requires surgically obtained tissue. To our knowledge, this is the first case with these features.

S1428 Occurrence of Gastric Cancer in Patients with Juvenile Polyposis Syndrome: A Systematic Review and Meta-Analysis

Introduction: Juvenile polyposis syndrome (JPS) is an autosomal dominant gastrointestinal (GI) polyposis syndrome that affects 1 in 100,000 to 160,000 people. The germline pathogenic variants (PV) in the SMAD4 and BMPR1A genes cause JPS in 60% cases. The syndrome predisposes to hamartomatous GI polyps especially in the colon. It also increases the risk of colonic and gastric cancer. But, due to its rarity, and likely ascertainment bias in published studies, the true rate of gastric cancer in JPS is unknown. Accurate information regarding the risk of gastric cancer may help individualize surveillance endoscopy intervals in these patients. Hence, we conducted a systematic review and meta-analysis to assess the occurrence of gastric cancer in patients with JPS. Methods: We searched Medline, Embase and Scopus databases for keywords ‘Juvenile polyposis syndrome, juvenile polyps, stomach cancer, and hereditary cancers.’ All published studies from January 1974 to May 2021 were screened. The diagnosis of JPS was based on phenotype: >3 colonic juvenile polyps (JP), or multiple JP in other parts of the GI tract or family history of JPS and any number of JP. Studies reporting upper GI manifestations in JPS patients were considered eligible for inclusion. The primary and secondary outcomes were to assess the occurrence of gastric cancer in all patients with JPS and per the underlying PV, respectively. A random-effects model was used. Inter-study heterogeneity was estimated using I2 statistic. Results: Nine studies including 553 patients met our criteria (Table 1). 254 (45.9%) patients had a SMAD4 PV, 154 (27.8%) had BMPR1A PV, 93 (16.8%) had no identifiable PVs and 52 (9.4%) patients were untested. The pooled occurrence of gastric cancer was 4.5% (95% CI: 1.9, 7.1; I2: 35.2%) (Figure 1a). The median age of gastric cancer detection was 42.5 years (range: 29-57.6 years). In studies with no prior genetic testing, gastric cancer occurred in 7.8 % (95% CI: 0,16.3; I2 = 0) patients. In patients with known PVs, gastric cancer was seen only in patients with SMAD4 (11.5%, 95% CI: 3.5, 19.6; I2: 67.1%) (Figure 1b). No gastric cancer was reported in patients with BMPR1A PV those without detectable PV. There was an overall moderate risk of bias in the studies. Conclusion: The risk of gastric cancer is increased in patients with JPS especially in patients with SMAD4 PV. The patients without prior PV testing in the present literature may harbor BMPR1A PV, these patients need to be studied in further large-scale studies.Figure 1.: CONSORT diagram Figure 2. Performance of Model.Table 1.: Characteristics of the included studies Footnotes: *Multicenter studies, †Age at any cancer diagnosis, not specific to gastric cancer, ‡Included patients from the same family, §13 patients were not tested for pathogenic variants, none of these patients developed gastric cancer. **The risk of bias of individual studies was assessed using the validated criteria by Hoy et al. Abbreviations: JPS: Juvenile Polyposis syndrome, PV: Pathogenic variants, NR: Not reported.

Peutz-Jeghers syndrome: Skin manifestations and endocrine anomalies (Review).

Peutz-Jeghers syndrome (PJS), a rare autosomal dominant serine/threonine kinase 11 (STK11)/ liver kinase B1 (LKB1) gene-related genodermatosis, is characterized by oral hyperpigmentation (OHP); multiple gastro-intestinal mucosal benign hamartomatous polyps causing local bleeding, occlusion, intussusception, post-resection small bowel syndrome, associated increased risk of small intestinal cancer (incidence during the third decade); and 76% cumulative higher risk than the global population of developing non-gastrointestinal tumors (female predominance) including ovarian/testicular neoplasia, pancreatic and gynecologic (breast, uterus, ovarian) cancers. Suggestive PJS-associated OHP requires STK11 genetic testing. Abdominal pain in an OHP patient may be related to PJS-associated polyps. Other features include focal depigmentation followed by hyperpigmentation, and xeroderma pigmentosum-like lesions. The severity of the dermatological findings is correlated with gastrointestinal polyps. The STK11 gene is linked to reserve of primordial follicles, polycystic ovary syndrome, female fertility, and spermatogenesis. PJS is associated with 2 types of ovarian sex-cord stroma tumors (SCSTs): annular tubules (SCTATs) and pure Sertoli cell tumors. SCSTs accounts for 8% of ovarian cancer and SCTATs represents 2% of SCST, which may be associated with the overproduction of progesterone. PJS-SCTAT vs. non-PJS-SCTAT reveals bilateral/multifocal, small tumors with a benign behavior vs. a unique ovarian, large tumor with increased malignant/metastasis risk. Male precocious puberty is due to large cell calcifying Sertoli cell tumors (LCCSCTs). Notably, 30-40% of LCCSCTs are caused by PJS or Carney complex. PJS-LCCSCT is not aggressive, but it may be bilateral/multifocal, with the ultrasound hallmark being micro-calcifications. Testicular, intra-tubular large cell hyalinizing Sertoli cell tumor is the second testicle neoplasia in PJS. The skin and mucosal lesions are useful markers of PJS, assisting with the early identification of hamartomatouspolyps and initiation of serial surveillance of ovarian, or testicular neoplasia.

Clinical Observation of Gastrointestinal Polyps Treated by High Frequency Electrotomy under Painless Digestive Endoscope

Clinical Observation of Gastrointestinal Polyps Treated by High Frequency Electrotomy under Painless Digestive Endoscope

Intussusception in Peutz-Jeghers Syndrome: Management of Unusual Acute Abdominal Presentation.

Peutz-Jeghers syndrome (PJS) is an autosomal dominant familial hamartomatous polyposis syndrome characterized by multiple gastrointestinal hamartomatous polyps and mucocutaneous melanin pigmentation. We report two cases, with no family history, presenting as emergency, one with perforation peritonitis due to spontaneous bowel disruption and another with bowel gangrene due to severe bowel congestion secondary to intussusception. Histological examination showed features of hamartomatous polyposis; other clinical features in these patients were suggestive of the diagnosis of Peutz-Jeghers syndrome. Given the multitude of carcinoma that these patients are susceptible to, aggressive screening protocols are recommended. Close monitoring and follow-up are essential in PJS patients for the prevention of potential complications, early detection of related malignancies due theirincreased risk for both intestinal and extraintestinal malignancies.

Double intussusception in a teenage child with Peutz-Jeghers syndrome: A case report

BACKGROUNDPeutz-Jeghers syndrome (PJS) is a genetic disorder characterized by the development of gastrointestinal hamartomatous polyps and mucocutaneous melanin pigmentation. Patients with PJS are at risk of complications such as intussusception. Intussusception is a condition where one segment of the intestine invaginates into another, causing intestinal obstruction. We report a PJS patient who was diagnosed with double intussusception in a single setting. CASE SUMMARYA 16-year-old teenage male PJS patient presented with a history of colicky abdominal pain, vomiting, blood in stools, loss of appetite, and weight loss. On abdominal examination, a vague mass was palpable over the right upper quadrant. Contrast-enhanced computed tomography (CT) of the abdomen was performed and an intussusception involving the jejunum and rectosigmoid junction was observed. The patient subsequently underwent a laparotomy and intussusception involving the jejunum and another over the ileum was noted intra-operatively. Bowel resection and an endoscopic polypectomy were performed, followed by a primary anastomosis. The patient was discharged well and reviewed again one month later, and was noted to be well.CONCLUSIONPJS patients have a high risk of intussusception and can be diagnosed accurately by endoscopic surveillance or radiologically with abdominal CT or magnetic resonance imaging. The mainstay of treatment is surgical intervention followed by endoscopic surveillance with periodic polypectomy.

Familial Adenomatous Polyposis-associated Traditional Serrated Adenoma of the Small Intestine: A Clinicopathologic and Molecular Analysis.

Familial adenomatous polyposis (FAP) is an inherited cancer predisposition syndrome associated with numerous gastrointestinal tract adenomatous polyps, as well as gastric fundic gland polyps and pyloric gland adenomas in the upper gastrointestinal tract. While colonic FAP-associated traditional serrated adenomas (TSAs) have been reported in a few studies, small bowel FAP-associated adenomas with TSA morphology have not been characterized. This study describes the clinicopathologic and molecular findings of this type of adenoma in the small bowel of patients with FAP. We reviewed small bowel adenomas in 45 consecutive FAP patients to identify adenomas with zones showing slit-like serrations, cells with eosinophilic cytoplasm, ectopic crypt formation, and vesicular nuclei. Sporadic small bowel adenomas from 51 consecutive patients were also reviewed for adenomas with the same features. Of the 177 polyps from 45 FAP patients and 60 polyps from 51 nonsyndromic patients, 18 TSAs from 9 FAP patients (20%) and 10 TSAs from the sporadic group (19.6%) were identified. FAP patients presented at a younger age than nonsyndromic patients (median: 43 vs. 66; P=0.0048). FAP-associated TSAs were asymptomatic and smaller than sporadic TSAs (median size: 0.6 vs. 2.5 cm; P=0.00006). Immunostaining for β-catenin and testing for BRAF and KRAS mutations were performed in a subset of the cohort. Nuclear β-catenin was seen in 1 FAP-associated TSA and 3 nonsyndromic TSAs. All TSAs (FAP-associated and nonsyndromic) showed wild-type BRAF, while KRAS mutations were identified only in the nonsyndromic setting. In summary, small bowel FAP-associated and sporadic TSAs share a similar morphology, and the BRAF-serrated pathway does not contribute to their pathogenesis.

Colorectal Polyps: A Histopathological Study in Tertiary Care Center

Introduction: Gastrointestinal polyps are commonly encountered in the colorectal region. They can be non-neoplastic or neoplastic. Neoplastic polyps include adenomas which are clinically important because of their premalignant nature. The study was carried out to analyze the histomorphological spectrum of polyps; in our institution with special emphasis on adenomatous polyps.Material and methods: This is a retrospective study done from January 2015 to December 2019 in the Department of Pathology, Dhulikhel Hospital - Kathmandu University Hospital (DH - KUH). Relevant clinical data of the patients were obtained from the histopathological records of the patient from the pathology department and biopsies stained with Haematoxylin and Eosin were studied under the light microscope.Results: A total of 168 cases of polyp were studied from 125 patients. The most common indication for colonoscopy in patients with polyp was per rectal bleeding. The age of the patient ranged from 2 to 83 years. The rectum was the commonest location. 106(63.1%) of polyps were non-neoplastic and 6(36.9%) of polyps were neoplastic. Juvenile polyp(71;42.3%) was the commonest polyp. Tubular adenoma(55;32.7%) was the commonest neoplastic polyp. Themaximum number of neoplastic polyps were seen in the age group of 51-60years (11;29.7%). Male predominance was seen in neoplastic as well as a non-neoplastic polyp. High grade adenoma(4;6.7%) was more commonly seen in adenomatous polyp >2cm(3;75%) followed by 1-2cm(1;25%) and none in <1cm.Conclusions: This study gives a fair insight into the distribution of neoplastic and nonneoplastic polyp in the colorectal region. Adenomatous polyps are premalignant.

A novel pathogenic splice site variation in STK11 gene results in Peutz-Jeghers syndrome.

BackgroundPeutz–Jeghers syndrome (PJS) is a rare autosomal dominantly inherited disease resulting in multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation, and an increased risk of various types of cancer, and is caused by variations in the serine/threonine protein kinase STK11 (LKB1).MethodsSTK11 gene variations were identified by analyzing STK11 cDNA and genomic DNA. Minigenes carrying the wild‐type and mutant sequences were subjected to in vitro splicing assay to dissect the features of these mutations. The different distribution of wild‐type and mutant protein in cells were tested by Immunofluorescence assays and the functional analysis of the variation were performed using Western blot.ResultsA novel heterozygous splice‐acceptor site variation (c.921‐2 A>C) in intron 7 of the STK11 gene which is co‐segregates with the PJS phenotypes in the proband and all the affected family members and three previously reported variations (c.180C>G, c.580G>A, c.787_790del) were identified in the four families. The c.921‐2 A>C substitution resulted in the inactivation of a splice site and the utilization of a cryptic splice acceptor site surrounding exon 8, generating three different aberrant RNA transcripts, leading to frameshift translation and protein truncation. The results of minigenes indicated that the spliceosome can use a variety of 3’ acceptor site sequences to pair with a given 5’ donor site. The immunofluorescent visualization showed that the distribution of mutant STK11 was different from that of wild‐type STK11, suggesting the mutation may be the causative effect on the dysfunction of the mutant protein. The rescue experiments indicated that the failure of suppressing mTOR phosphorylation by shRNA STK11 could be eliminated by supply of wild‐type STK11 rather than mutant STK11.ConclusionWe identified a novel heterozygous mutation (c.921‐2 A>C) in the STK11 in a Chinese PJS family. Haploinsufficiency of STK11 might contribute to the pathogenesis of the disease.

The Clinical Spectrum of PTEN Hamartoma Tumor Syndrome: Exploring the Value of Thyroid Surveillance

Introduction: Phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS) comprises a collection of clinical features characterized by constitutional variants in PTEN. Several guidelines recommend thyroid screening, beginning at the pediatric age at the time of PHTS diagnosis; however, the benefits of early surveillance has not been well defined. Methods: We conducted a retrospective investigation of patients followed up at the Children’s Hospital of Philadelphia with a diagnosis of PHTS between January 2003 and June 2019. In total, 81 patients younger than 19 years were identified. Results: The most common clinical feature at presentation was macrocephaly (85.1%), followed by impaired development (42.0%), skin/oral lesions (30.9%), and autism spectrum disorder (27.2%). A total of 58 of 81 patients underwent thyroid surveillance, with 30 patients (51.7%) found to have a nodule(s). Ultimately, 16 patients underwent thyroidectomy, with 7.4% (6/81) diagnosed with thyroid cancer. All thyroid cancer patients were older than 10 years at diagnosis, and all displayed low-invasive behavior. Of the patients younger than 10 years at the time of thyroid ultrasound (US) surveillance, 71.4% (15/21) had a normal US. The remaining 6 patients had thyroid nodules, including 4 undergoing thyroid surgery with benign histology. Discussion/Conclusion: Patients with macrocephaly, impaired cognitive development and thyroid nodules, and/or early-onset gastrointestinal polyps should undergo constitutional testing for PHTS. There does not appear to be a clinical advantage to initiating thyroid US surveillance before 10 years of age. In PHTS patients with a normal physical examination, thyroid US surveillance can be delayed until 10 years of age.

Gastroenterological clinical case

Gastrointestinal polyps are frequent in children and represent the most common cause of colorectal bleeding in this age group. Among those, juvenile polyps are the most frequently found. Intermittent mild hematochezia is the main symptom of colon polyps. Most polyps are pedunculated and, when located in the rectum, may prolapse. In most cases, juvenile polyps are solitary and located in rectosigmoid. Although malignancy risk of a solitary juvenile polyp is very small, excision is recommended to confirm benign nature. Total colonoscopy should be considered to exclude multiple or proximal polyps.

The Histopathological Study of Gastrointestinal Polyps

Polyps covered by non-neoplastic squamous epithelium may develop anywhere in the esophagus. Squamous polyps may be divided in to two types: Inflammatory polyps and squamous papillomas. To study the incidence and morphology of Gastro Intestinal Tract polyps from specimens received at Sree Balaji Medical College and Hospital, Chennai. To analyze the incidence and morphological features of malignancies associated with polyps. Of the 102 cases, intestinal cancer was found predominately 51(50%) followed by stomach. The ages ranged from 17 to 77 yrs and average was 44 yrs. The female ratio was 0.77. Expression of P53 was varied with the property of the polyps and it could be a useful marker for determining the treatment regime.

Snare rotation technique: a simple tip for successful polypectomy for non-pedunculated gastrointestinal polyps.

Snare rotation technique: a simple tip for successful polypectomy for non-pedunculated gastrointestinal polyps.

An improved framework for polyp image segmentation based on SegNet architecture

AbstractA polyp is one of the major causes of gastroenterology, which leads to colorectal cancer. The detection of polyps by colonoscopy imaging is a significant challenge because of the diversity in polyp structure and lack of examination accuracy. To solve this problem, the automatic segmentation of polyps can be used to enhance examination accuracy and reduce gastrointestinal (GI) disease. In this paper, the framework of polyp image segmentation is developed by a deep learning approach, especially a convolutional neural network. This proposed framework used the Kvasir‐SEG database, which contains 1000 GI polyp images and corresponding segmentation masks according to annotation by medical experts. This database is divided into 900 for training images and 100 for testing images. This framework is based on image preprocessing and two types of SegNet architecture to obtain the segmented polyp image. This paper has demonstrated state‐of‐the‐art performance on both VGG‐16, and VGG‐19 networks for training and testing data to address colorectal cancer screening rates. The results confirmed that the VGG‐19 model has outperformed the VGG‐16 model via all evaluation parameters except sensitivity for the polyp segmentation on the Kvasir‐SEG dataset. Additionally, it will support gastroenterologists during medical strategy to correctly choose the treatment with less time.