We present a case of a 47 year-old Caucasian female with a history of systemic lupus erythematosus, treated chronically with prednisone, who was admitted to the medical intensive care unit with community acquired pneumonia and sepsis. She subsequently developed hematochezia and required multiple blood transfusions. Colonoscopy revealed active colitis in the ascending colon and biopsies were consistent with invasive Mucormycosis. The patient was tapered off her corticosteroids and treated with amphotericin B for four weeks with marked clinical improvement. There was no detected Mucormycosis on follow up colonoscopy with biopsies. Mucormycosis typically presents as an opportunistic infection in immunocompromised patients. In the majority of cases it follows a fulminate and fatal course. Predisposing factors include solid organ transplants, diabetes mellitus, malnutrition, corticosteroid dependency, hematologic malignancy, iron overload treated with deferoxamine, severe burns, metabolic acidosis, and cancer chemotherapy. Diagnosis is made histologically by demonstrating tissue and vessel invasion by the organism. Survival depends on early diagnosis and intervention. Gastrointestinal involvement is rare. A review of the literature revealed 62 cases of mucormycosis limited to the gastrointestinal tract. These cases were analyzed based on available data regarding age, sex, predisposing factors, clinical presentation, endoscopic appearance, pathology, treatment, and outcome. We found that use of immunosuppressive medications was the most common risk factor associated with the development of gastrointestinal mucormycosis. Those infected typically presented with abdominal pain, fever, and/or gastrointestinal bleeding. The most common site of infection was the stomach, followed by the colon. Over one-third of cases already had multiple sites of gastrointestinal involvement. On endoscopy, ulceration and ischemia were the most common mucosal patterns observed. The outcome was poor as the majority of patients with invasive disease succumbed to the infection. Those with the best chance of survival were treated with a combination of surgical and medical modalities.