Gastric Teratoma Research Articles

Immature gastric teratoma: A rare tumour

Gastric teratoma is a very rare tumour. We reviewed the literature and found that only around 100 cases have been reported. Almost all reported cases of gastric teratoma were of mature variety. Only a few cases were of immature variety. The rarity of the disease makes the diagnosis very difficult most of the cases occurred in infants. The disease is more common in males than in females. Majority of cases have been reported to arise from the greater curvature and posterior wall of the stomach. Histopathological examination confirms the diagnosis. Treatment of choice is surgical excision with close follow up. Following surgical excision prognosis is excellent. Hence, in an infant who presents with abdominal lump gastric teratoma should be kept as one of the differential diagnosis. Here, we are reporting a case of immature teratoma.

Immature Gastric Teratoma in a Newborn: A Case Report

A case of immature gastric teratoma in a neonate is being reported here. The neonate was presented with abdominal mass and distension and managed with excision of mass; the patient is doing fine postoperatively.

Gastric teratoma presented as gastric outlet obstruction and melena; report of rare case.

Gastric teratoma is a very rare tumor, accounting for less than 1% of all teratomas in infants and children. Melena or upper gastrointestinal tract bleeding in newborns and infants is a rare event and is usually caused by a benign lesion. Gastric teratoma has been reported as a cause of gastrointestinal bleeding on a few occasions. As gastric teratomas generally present as a palpable abdominal mass, more aggressive solid masses of childhood must be excluded. We present intramural extension of gastric teratoma presented as symptom of gastric outlet obstruction and melena.

Gastric teratoma: A series of 7 cases

BackgroundGastric teratoma is a rare entity comprising less than 1% of germ cell tumors of childhood. We present a series of seven gastric teratomas with a review of literature. ObjectiveTo study the demographic profile, clinicopathological features and follow-up data of gastric teratomas. MethodsWe did a retrospective analysis of 7 cases of gastric teratomas more than 15years and studied their demographic profiles, clinicopathological features and follow-up data. ResultsWe came across 7 cases of gastric teratomas out of which 5 were mature and 2 were immature. One case of immature teratoma came back with recurrence and another one had an unusual finding of presence of renal and pulmonary tissues, which has not been reported earlier. ConclusionOurs is the second largest case series of gastric teratomas in the pediatric age group and 2 out of 7 of our cases had immature elements. We also take this opportunity to report a case of gastric teratoma with the unusual histological finding of immature renal and pulmonary tissues, which has not been described previously.

Gastric teratoma in children: Our experience

Summary Background/Introduction Gastric teratoma is an extremely rare tumor, almost exclusively benign, accounting for Purpose/Aim This work aimed to study the clinical presentation, investigation modalities, intraoperative findings, histopathological types, and surgical outcome of gastric teratoma in children. Methods A retrospective study was performed from 1993 to 2013 in two pediatric institutes. Results There were eight patients with gastric teratoma and all of them were male. Seven (87.5%) patients presented in infancy, out of which four (50%) patients were neonates, while one (12.5%) patient was a toddler. The manifestations were as follows: a palpable abdominal mass in seven (87.5%), abdominal distension in five (67.5%), anemia in four (50%), respiratory distress in three (37.5%), gastric outlet obstruction with recurrent vomiting in three (37.5%), and abdominal pain, anorexia, and melena in one (12.5%) each. Ultrasonography showed a solid cystic mass with mixed echogenicity in all the patients, while calcification was seen in seven (87.5%) cases. Computed tomography, which was performed in four (50%) patients, clinched the preoperative diagnosis. A growth was present on the posteroinferior wall near the greater curvature in seven (87.5%) cases, while in one (12.5%) patient, it was arising from the lesser curvature. Excision of the tumor was performed in all patients. Histopathology was mature type in six (75%) cases, and immature Grade 1 and 2 in one (12.5%) each. Complications were seen in five (62.5%) cases, and one (12.5%) mortality was observed in our series. All other patients were doing well in the postoperative period. Conclusion Gastric teratoma is almost always benign and has predilection for male sex. It commonly presents as a palpable abdominal mass. Complete surgical excision is curative. Close observation is recommended for Grade 2 and 3 immature teratomas. The prognosis is excellent.

Mature Cystic Gastric Teratoma in an Infant: A Case Presenting with a Gastrointestinal Bleeding

Gastric teratoma is an extremely rare tumor that accounts for less than 1% of all teratomas. Gastric teratoma is mostly presented as a palpable abdominal mass, and is rarely accompanied with gastrointestinal bleeding such as melena or hematemesis. A 5-month-old male infant was brought with a history of pale facial color and dark-colored stool. The hemoglobin level was at 6.1 g/dL, with melena having begun 1 month previous. Upper gastrointestinal endoscopy revealed a polypoid mass with bleeding at the upper body and lesser curvature of the stomach. Wedge resection of the stomach was performed and histopathological analysis confirmed the mass to be a mature cystic teratoma. There was no recurrence after the operation during follow-up.

Rare Case of Immature Gastric Teratoma

Introduction Teratomas are rare and complex tumors with components from more than one of the three germ cell layers. Teratomas range from benign, well-differentiated (mature) cystic lesions to those that are solid and malignant (immature). The incidence of all teratomas is estimated at 1:10,000-1:20,000 newborns. Gastric teratomas represent only 1-2% of all teratomas. Case presentation We report a case of gastric teratoma of a 2 month-old boy who presented with abdominal distension. Diagnosis was established by physical examination, ultrasonography and computed tomography. The tumor measured 13/10/5.5 cm and weighted 390 grams and was surgically excised. Histological examination revealed an immature gastric teratoma. We also reviewed existing clinical and genetic data on gastric teratomas. Association of gastric teratomas with other congenital anomalies or tumors is very rare. Reported cases include: Beckwith-Wiedemann syndrome (involved:11p15, IGF2), Hodgkin disease (developed 3 yrs. post-resection) and focal neuroblastoma. Recent theories include extraembryonic cells; also have been hypothesized to originate from pluripotent cells present in the gastric wall. Conclusion Gastric teratomas are extremely rare tumors. Complete resection induce a good outcome.

Neonatal gastric teratoma: a rare entity.

Gastric Teratoma is an extremely rare neoplasm seen in children. It is mostly benign and predominantly seen in males presenting with an abdominal mass. The lung and stomach are very unusual sites for teratoma. Gastric teratoma accounts for less than 1% of all teratomas, less than 100 cases are reported in literature. We report a case in a 20-day-old infant who presented with large abdominal mass; our case is an addition to the few limited known gastric teratomas reported in the world literature.

An unusual cause of neonatal apnoea (Discussion and Diagnosis)

The Case Presentation can be found on page 772. DISCUSSION While apnoea is a common problem in preterm infants, in term neonates, apnoea should always raise concern for a pathologic cause. This differential diagnosis of apnoea in the term neonate is broad. As episodes are usually brief, it can be difficult to classify occurrences as central, obstructive or mixed. Initial work-up should focus on identifying potentially treatable, life-threatening conditions such as sepsis, metabolic disturbances, accidental or intentional poisoning, abusive head injury, seizures and cardiovascular causes. To my knowledge, neonatal apnoea has not been previously described in the literature as presentation of gastric teratoma. Although the overall prevalence of neonatal teratomas is unknown, themost common form, sacrococcygeal teratoma, occurs once in every 14,900 live births (1). While rare, neonatal teratomas represent the most common congenital tumours and comprise 35% of neonatal tumours (2). The majority of teratomas in children and adults arise from gonadal sites; however, teratomas in neonates most commonly arise from extra-gonadal sites such as the sacrococcygeal area and mediastinum. Gastric teratomas account for less than one percentage of neonatal teratomas (3). To date, there are nine reported cases of neonatal gastric teratomas in the literature. Clinical presentations described by previous authors include severe anaemia, gastrointestinal bleeding, abdominal distension and respiratory distress (4–6). Neonatal teratomas are usually benign; therefore, complications are related to mass effect rather than malignant potential. Surgical resection is curative, but complete resection is often challenging due to the location of these tumours. Alpha-fetoprotein (AFP) should be followed as a marker of incomplete resection or recurrence (7). Interpretation of serum AFP in the neonatal period is challenging as levels are normally elevated at birth and decline over the first year of life. In this patient, serum AFP was 3225 ng/mL prior to resection, 40.5 ng/mL at 2 months and 1.5 ng/mL at 1 year of age. Yearly MRI has not shown evidence of recurrence. The patient is now 5-year old. He is growing appropriately and performing well in school.

Immature Gastric Teratoma in an Infant

Gastric teratomas are very rare tumors accounting for less than 1% of all teratomas of infants and children. Little more than 100 cases of gastric teratomas are reported in the literature; out of which, very few of them are of immature variety. Complete excision of the gastric teratoma carries a good prognosis. We hereby report a case of immature gastric teratoma in a 3-month-old baby.

Immature Gastroesophageal Teratoma: Second Case Report and Literature Review

Gastric and gastroesophageal teratoma are rare tumors that involve the stomach and gastroesophageal zone, both are of the same pathological nature. In reviewing literature, nearly 110 cases were reported, but the teratoma that involved the gastroesophageal area is extremely rare as only one case of mature gastroesophageal teratoma has been reported previously. Presented is the second case of gastroesophageal teratoma; a case of 18-days-old male patient with large immature gastroesophageal teratoma which was recognized as abdominal mass on antenatal ultrasound, but patient presented five days after noticing the abdominal mass by his mother. Discussion with the relevant technical considerations in the management of the teratoma originating from or involving the gastro-esophageal junction was considered.

A Childhood Gastric Teratoma : A Case Report and Review of The Literature

Gastric teratomas are extremely rare tumors. A six year old boy presented with abdominal mass. Ultrasound of abdomen showed mixed echogenic lesion. CT scan showed a mass with solid and cystic components and internal calcifications. At operation a tumor arising from the posterior wall of the stomach was found. It was exogastric as well as endogastric in location. Histopathological examination revealed a mature teratoma.DOI: http://dx.doi.org/10.3329/birdem.v2i2.12329(Birdem Med J 2012; 2(2): 121-123)

Gastric Teratoma—Unusual Cause of Neonatal Obstructive Jaundice: A Case Report

The gastric teratoma is a very rare tumour that usually presents as an abdominal mass, gastrointestinal bleeding with/without features of gastric outlet obstruction. We report a rare case of immature gastric teratoma in a two months old female child who presented with abdominal lump and jaundice. The presentation was a diagnostic challenge and a dilemma, added by the fine needle aspiration cytology (FNAC) suggestive of small round cell tumor, favouring diagnosis of Wilms tumor over Neuroblastoma. Intra-operatively the tumor was found compressing upon the common bile duct (CBD). Final histopathological examination (HPE) revealed immature gastric teratoma Grade III. We wish to highlight this unusual presentation of gastric teratoma manifesting with obstructive jaundice and fallacy of FNAC in the diagnosis of teratomas.

Gastric Teratoma in an Infant: A Rare Case Report and Discussion

Gastric teratoma is a rare tumor, accounting for less than 1% of all teratomas in infants & children. To date, only about 102 cases have been reported in the literature. A 10month old infant was brought with a history of upper abdominal mass which was otherwise asymptomatic. On evaluation it was diagnosed as gastric teratoma. On laparotomy the mass was found to be originating from lesser curvature of stomach. Mass was excised and histopathologically it was a mature cystic teratoma. No recurrence after 18months of follow-up.

Immature gastric teratoma in a newborn

Gastric teratomas are very rare embryonal neoplasms and accounts for less than 1% of all teratomas occurring in infants and children. It is usually seen in male infants who present with upper abdominal mass and commonly it is benign. This report describes a large immature grade II gastric teratoma in a male newborn. The tumor was treated with total excision including part of the stomach. Key words: Gastric teratoma, newborn, immature.

Gastric teratoma: unusual location and difficulties in diagnosis

Gastric teratoma: unusual location and difficulties in diagnosis

Rapidly grown congenital fetal immature gastric teratoma causing severe neonatal respiratory distress

A pregnant woman in the mid-third trimester developed complications with enlarged fetal abdomen and polyhydramnios. Prenatal ultrasound visualized dilated bowel, intraperitoneal calcifications, ascites, hydroceles and polyhydramnios, giving the impression of meconium peritonitis. The fetal abdomen continued to increased in size, and maternal dyspnea due to polyhydramnios was aggravated. She underwent a cesarean section at 36 + 1 weeks' gestation. The delivery was followed by severe neonatal respiratory distress due to the huge mass in the abdomen. The tumor was successfully removed by emergency surgery and diagnosed as immature gastric teratoma. No other associated anomaly was found. The infant made a good progress after the operation.

Gastric teratoma in a 6-month-old boy

Gastric teratomas are very rare embryonal neoplasms, accounting for 2.6% of all perinatal diagnosed germ cell tumours. About 85% are well-differentiated mature lesions and about 15% are immature tumours with the potential of malignant transformation. The recommended therapy for gastric teratomas is surgical excision. We present the case of a 6-month-old boy with an incidentally detected epigastric mass. The histological examination revealed a mature gastric teratoma. The diagnostic imaging, therapy and postoperative follow-up are discussed.

胃憩室内胃癌を合併した成人胃奇形腫の1例

胃憩室内胃癌を合併した成人胃奇形腫の1例

Protocol for the Examination of Specimens From Pediatric and Adult Patients With Extragonadal Germ Cell Tumors

The College of American Pathologists offers these protocols to assist pathologists in providing clinically useful and relevant information when reporting results of surgical specimen examinations. The College regards the reporting elements in the ‘‘Surgical Pathology Cancer Case Summary (Checklist)’’ portion of the protocols as essential elements of the pathology report. However, the manner in which these elements are reported is at the discretion of each specific pathologist, taking into account clinician preferences, institutional policies, and individual practice. The College developed these protocols as an educational tool to assist pathologists in the useful reporting of relevant information. It did not issue the protocols for use in litigation, reimbursement, or other contexts. Nevertheless, the College recognizes that the protocols might be used by hospitals, attorneys, payers, and others. Indeed, effective January 1, 2004, the Commission on Cancer of the American College of Surgeons mandated the use of the checklist elements of the protocols as part of its Cancer Program Standards for Approved Cancer Programs. Therefore, it becomes even more important for pathologists to familiarize themselves with these documents. At the same time, the College cautions that use of the protocols other than for their intended educational purpose may involve additional considerations that are beyond the scope of these documents.