Gastric Teratoma Research Articles

Case of adult gastric teratoma: common tumour in uncommon location

Case of adult gastric teratoma: common tumour in uncommon location

Immature gastric teratoma in an infant presenting as retroperitoneal mass.

Immature gastric teratoma in an infant presenting as retroperitoneal mass.

Immature gastric teratoma in infancy: A case report

Intra-abdominal mass in neonatal period found in approximately 1 in every 1000 live births. Germ cell tumor, including teratomas account for 9% of intra-abdominal mass in children. Teratoma is defined as germ cell tumor composed of tissue derived from ectoderm, endoderm, and mesoderm. Teratoma has been described in various location. Gastric teratoma is uncommon contributes less than 1% among teratoma in pediatric. The age at presentation occurs principally during infant and young children. A 7-month-old boy referred with chief complain abdominal mass since 2 months ago in upper left abdomen. Within 2 months the mass was getting bigger to size of a coconut. Abdominal examination revealed mass in left hypochondria, 15x12 × 10 cm in size, well defined, irregular surface, mobile, no vena ectasia, and dull in percussion. CT abdomen with contrast showed cystic mass which caused displacement of intraabdominal organs and colon. He was diagnosed with intrabdominal tumor et causa intraabdominal teratoma differential diagnoosis mesenterical cyst. Exploratory laparotomy and tumor excision was performed. Pathologic examination revealed grade III immature teratoma in gastric. Adjuvant chemotherapy was started immediately. The most common presentation of gastric teratomas is palpable abdominal mass in epigastrium and left side of the abdomen with abdominal distention. Most of the case was difficult to diagnosed preoperative and complementary studies must be made to confirm diagnosis. The recommended treatment for both mature and immature teratomas is total excision. In case where the alpha-fetoprotein level rising, chemotheraphy is administered.

Zreli gastrični teratom kod ženskog odojčeta sa malrotacijom creva - prikaz slučaja

Gastric teratoma is a extremely infrequent tumor and accounts for less than 1% of all teratomas among children population with male predominance. Case history: Herewith is described a case of mature gastric teratoma in a three months-old female infant associated with malrotation, hypotonia, torticollis and fusion of labia minoria. Due to the abdominal distension, the child was admitted to the Paediatric Surgery Department. On physical examination, a large lump was palpable, and laboratory findings were normal. Computed tomography (CT) showed a major heterogeneous solid formation within the right hemi-abdomen, extending to pelvis and crossing the midline. The infant underwent surgery and complete excision of tumor originating from lesser curvature of the stomach was made. Tumor was weighing 600 gr and was 10 x 14 x 8 cm large. The histopathological examination finding pointed to mature gastric teratoma. The post-operative course and further follow-up were eventless. Conclusion: As soon as the diagnosis is made, the surgery is of paramount importance, especially in cases of immature teratomas, where malignant alteration is possible.

Gastric teratomas in paediatric population: A case series from a tertiary care centre of Northern India

A retrospective analysis of all paediatric patients diagnosed and treated for gastric teratomas in our hospital over the past 20 years was carried out (1997–2017). A database of the clinic-pathological characteristics of these patients was developed. In all, 7 patients were identified. All the patients underwent resection and were followed up every 6 months. The investigations performed included routine blood investigations, X-ray, alpha fetoproteins (AFP), beta HCG levels and a CT scan of the abdomen. There were seven patients with gastric teratomas and all of them were male except one female. Their ages ranged from 1 day to 4 years. Six (85.7%) patients presented during infancy. The manifestations were as follows: a palpable abdominal mass followed by anemia, respiratory distress, abdominal distension, gastric outlet obstruction with recurrent vomiting, and abdominal pain, anorexia, and melena. Histopathology was mature type in five (71.4%) cases, and immature Grades 1 and 2 in one (14.2%) each. Complications were seen in four (57.1%) cases, and there was one (14.2%) mortality in our series. Recurrence was seen in two of our cases. The preoperative diagnosis of Gastric teratoma may be challenging, but with recent advances in imaging an accurate diagnosis and staging is possible. Complete surgical excision is curative in all cases, with close observation and follow-up. • Gastric teratoma is an exceptionally rare embryonic neoplasm occurring in neonatal period and infancy. • Due to the paucity of the number of cases, the natural history of the disease is not fully understood and its preoperative diagnosis remains elusive. • Complete surgical excision is curative in all cases, with close observation and follow-up being recommended in Grade 2 and 3 immature teratomas. • The detection of immature component carries a prognostic implication and hence, extensive sampling is essential. • Postoperatively, the prognosis is excellent. • Long term follow-up with AFP and beta hCG depending on the type is the standard protocol to be adopted.

Laparoscopic Surgical Management of a Gastric Dumbbell Teratoma

Background: Teratomas are totipotent tumors commonly seen in gonadal and extragonadal region. Gastric teratomas are very rare and account for <1% of the cases. Conventionally, the treatment of gastric teratoma is open excision of the tumor. We present a rare variant of a gastric teratoma managed laparoscopically. Clinical Description: An 8 months' old male was noted to have pallor and history of blood-tinged spit-ups. The child was worked up for the cause of anemia with an upper gastrointestinal disorder as the first differential. The child had significant anemia with a hemoglobin level of 6 g/dl and was transfused packed red blood cells sequential imaging with an abdominal ultrasound, contrast-enhanced computerized tomographic scan, and magnetic resonance imaging identified the presence of a gastric teratoma with both an intragastric and extragastric component (dumbbell variant). He was referred to the pediatric surgery services for further management. Management: The infant underwent a gastroscopy to further define the intragastric component of the mass. This revealed a sessile submucosal polypoidal lesion with multiple areas of erosions in the region of the fundus. A biopsy from this suggested a teratoma. The child underwent a total laparoscopic excision of the lesion and recovered well. The histopathology of the tumor was consistent with a mature cystic teratoma (Grade 0). The postoperative period was uneventful. Conclusion: Laparoscopic complete surgical excision of the dumbbell variant of gastric teratoma in this child was curative, reduced morbidity, and hospital stay compared to usual open surgery.

Gastric Teratoma in Infant

Gastric teratomas (GTs) are very rare tumors in children. They usually present with a palpable mass in the upper abdomen. We report a case of GT in a 4-month-old male infant who was presented with a palpable central abdominal mass. Ultrasound and computed tomography (CT) scan revealed a huge mass with heterogenous consistency and scattered calcification within the mass, extending from epigastric to hypogastric region. His biochemical marker of alpha-fetoprotein (AFP) was raised (1277 ng/mL). The preoperative clinical diagnosis was suspected teratoma but not specifically gastric one. On laparotomy, the mass was found to be attached with the greater curvature of the stomach and it was excised completely with all layers of the attached part of the greater curvature of the stomach wall. Histopathology confirmed it was a grade-I immature GT. The rarity of the origin of teratoma in addition to its immature variety prompted us to report the case.

Immature gastric teratoma in an infant: A rare entity with review of literature

Immature gastric teratoma in an infant: A rare entity with review of literature

Immature gastric teratoma in an infant: A case report

Immature gastric teratoma is an extremely rare embryonal neoplasm. Although teratomas have been identified in most body regions, the sacrococcygeal is the most commonly involved site, followed by cervicofacial, mediastinal, gonadal, and retroperitoneal regions. The stomach is rarely involved, accounting for <1% of teratomas. Most of the cases occur in infants. The rarity of this disease in unusual sites makes the diagnosis difficult. We report an unusual case of an immature gastric teratoma in an infant who clinically presented with upper respiratory tract infection. Contrast-enhanced computed tomography abdominal was performed which revealed a large exogastric mass. Histopathological examination confirmed it to be an immature gastric teratoma. This has an excellent prognosis if treated promptly. Complete surgical excision is usually curative. Hence, awareness of this entity in unusual sites like the stomach is required to make the right diagnosis. Until date, only 35 cases of immature gastric teratomas have been reported in the published literature. We, therefore, report one such case in the stomach of a neonate.

Congenital Benign Metastasizing Teratoma? A Case Report and Literature Review

Abstract A case is presented of a patient with completely resected congenital immature gastric teratoma containing yolk sac tumor, with locoregional recurrence and peritoneal seeding 25 months later as pure mature teratoma. To the knowledge of the author, this is the first case of its type to progress purely as mature teratoma.

Hydrops fetalis and neonatal abdominal compartment syndrome continuum from immature gastric teratoma: a case report

BackgroundHydrops fetalis as well as abdominal compartment syndrome (ACS) are conditions that are associated with high mortality rates. A rare case of immature gastric teratoma causing fetal hydrops and subsequent ACS is presented. The related pathophysiologic mechanisms are discussed, and the importance of timely recognition and appropriate interventions are highlighted.Case presentationThe male patient was born preterm, weighing 3.9 kg., by Cesarean section. Prior prenatal ultrasounds were normal, but a scan done just before delivery had findings indicating polyhydramnios, fetal ascites, and meconium peritonitis. Upon delivery, the patient had respiratory distress, anasarca and a massively distended abdomen. Resuscitation measures, including ventilatory support, were instituted. Imaging studies showed ascites as well as a large, complex intra-abdominal lesion with calcifications. In the succeeding hours, anuria persisted, anasarca worsened, the abdomen became more distended, and inotrope requirements increased. The occurrence of ACS, from what was presumed to be a retroperitoneal teratoma, was therefore considered. Laparotomy was done on the 28th hour of life, with en bloc excision of a massive tumor and attached section of the greater curvature of the stomach. Passage of urine occurred intra-operatively, and the patient was soon after weaned off inotropes and ventilator support. The histopathologic result was immature gastric teratoma. No chemotherapy was given, and the patient’s serum AFP is at normal levels 15 months following surgery.ConclusionThe presence of a massive intra-abdominal lesion can result in the pathophysiologic continuum of hydrops fetalis and neonatal ACS. The early recognition of such an association can enable appropriate expectant management of similarly affected neonates, including emergent decompression laparotomy.

Case report of gastric teratoma masquerading as neonatal intestinal obstruction

BackgroundTeratomas are rare in neonates. They are embryonic neoplasms containing elements from all the three germ layers. Commonly, they arise in the ovary and testis. Rarely do they arise from the gastrointestinal tract, as in our case. Intestinal obstruction in neonates is usually due to congenital obstructive malformation such as atresia and/or stenosis of the gastrointestinal tract with or without sepsis.Case presentationAn outborn 5-day neonate, generally well before admission presented with non-bilious vomiting, abdominal distension and a palpable mass extending from the right to left flank across the centre. Bilious aspirates/vomiting usually indicates obstruction distal to the ampulla of Vater. Clear aspirates indicate obstruction proximal to the ampulla which usually present by second day of life.Possibility of a mass lesion such as a “teratoma” causing gastrointestinal obstruction needs a high index of suspicion. Imaging studies of plain X-ray chest with abdomen enhanced our clinical suspicion which was promptly followed by ultrasonography of the abdomen and thereafter computerized tomography of the abdomen which provided corroborative evidence. Laparotomy on the seventh day of life confirmed the clinical suspicion and imaging evidence of an exogastric mass arising from the postero-inferior wall of the stomach along its greater curvature. Histopathology revealed a mature teratoma.ConclusionA high index of clinical suspicion by the paediatrician/neonatologist attending a neonate with abdominal distension suggestive of gastrointestinal obstruction, immediate cardiopulmonary, hemodynamic and circulatory stabilization, followed by prompt and appropriate imaging studies with timely surgical consultation holds the key to quality outcome.

Gastric teratoma invasion and bulb fistula formation in an adult: report of one case and literature review

Gastric teratoma primarily occurs within 3 months following birth, and is a rare pattern of gastric lesion in adult patients. The present study reports the case of a 60-year-old male patient who was diagnosed with a tumour in the lesser curvature within the gastric cardia area, which grew outside the cavity, invaded into the duodenal bulb and formed a gastroduodenal fistula. Briefly, initial gastroscopy upon hospital admission revealed mucosa bulging into the gastric cavity, gastric ulcer and duodenal bulb mucosal congestion with oedema. Subsequent computed tomography scans showed lesser curvature-occupying hamartoma in the gastric cardia area, and upper gastrointestinal angiography confirmed gastric stromal tumour complicated with cardia duodenal fistula. Total gastrectomy followed by Roux-en-y oesophagojejunostomy was performed, and pathology analysis of the tissue specimen confirmed mature gastric teratoma. The formation of a gastroduodenal bulb fistula with the tumour as a bridge is a rare phenomenon. A notable finding of the present case study was that the final diagnosis of gastric teratoma mainly depended on pathological examination.

Dual pathology a case report of yolk sac component in mature gastric teratoma

Gastric teratoma is a rare tumour accounting for less than 1% of all teratomas in pediatric age groups. We present a case of gastric teratoma in 33-month-old male infant who presented with abdominal pain for 2 months. Ultrasound of abdomen revealed a multi-cystic mass with mixed echogenicity arising from the lesser curvature of stomach. The mass was excised completely and sent for histopathological examination. Histopathology confirmed mixed germ cell tumour (gastric mature teratoma and yolk sac tumour). Serum AFP (alpha fetoprotein) and extensive sampling of the lesions can help in identification of other germ cell component. Keywords: Teratoma, Alpha fetoprotein, Yolk sac tumour.

Immature gastric teratoma in a newborn

Abstract We present a full-term male infant with a palpable abdominal mass who presented with severe haematemesis associated with cardiovascular compromise. Although an initial ultrasound imaging identified a left supra-renal calcified mass suggesting a neuroblastoma, further imaging suggested an atypical mass which was separate from the spleen and left kidney. An upper gastro-intestinal contrast study localised the mass to the stomach and a computed tomograph suggested the possibility of a gastric teratoma likely in combination with a raised serum Alpha-fetoprotein. The mass was completely surgically resected, and histology confirmed an immature gastric teratoma.We would like to draw the attention of clinicians of the possibility of a gastric teratoma in an infant who presents with an abdominal mass and haematemesis.

Neonatal Gastric Immature Teratoma Presenting as an Oncologic Emergency: A Report of a Case Requiring Differentiation From Neuroblastoma

Neonatal Gastric Immature Teratoma Presenting as an Oncologic Emergency: A Report of a Case Requiring Differentiation From Neuroblastoma

Gastric teratoma: Our 17 year experience

BackgroundTeratomas originating from the stomach are extremely rare and account for less than 1% of all cases of teratomas. This site of occurrence has unique diagnostic and management issues. MethodsA single centre case-record review of gastric teratomas presenting between January 2000 and April 2017 was performed. ResultsThirteen children were found to have gastric teratomas. Presenting features were abdominal distension in 12 (92%) and palpable abdominal mass in 9 (69%). At operation, 8 (61%) were exogastric tumors. The tumor was excised with partial gastrectomy (n=7, 54%), total gastrectomy (n=1, 8%), partial gastrectomy and limited transverse colectomy (n=2, 15%), and excision of small part of serosa (mucosal sparing) (n=3, 23%). Histopathologically, these were identified as mature gastric teratomas in 8 (61%). Three (23%) children died postoperatively. ConclusionGastric teratomas are rare, with the majority described as exogastric. Partial gastrectomy is always needed, but occasionally complete gastrectomy is necessary. Overall survival is >75% in our experience. Level of evidenceIV

Gastric Mature Teratoma in Newborn

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Immature Gastric Teratoma with Rhabdomyosarcomatous and Primitive Neuroectodermal Tumor Components in an Adult Patient: A Case Report

Immature Gastric Teratoma with Rhabdomyosarcomatous and Primitive Neuroectodermal Tumor Components in an Adult Patient: A Case Report

Gastric Teratoma: An Unusual Presentation and Location.

The gastric teratoma is a rare tumor that usually presents as an abdominal mass, with or without features of gastric outlet obstruction. We report two cases of gastric teratoma; one – mature in a male neonate and another – ruptured immature gastric teratoma in a female neonate.