Phase Of Gastric Acid Secretion Research Articles

Gastrin-related peptides as stimulants of pancreatic and gastric secretion.

Gastrin-related peptides as stimulants of pancreatic and gastric secretion.

POTENTIATION OF SHAM FEEDING RESPONSE IN PAVLOV POUCH DOGS BY SUBTHRESHOLD AMOUNTS OF GASTRIN WITH AND WITHOUT ACIDIFICATION OF DENERVATED ANTRUM.

AbstractThe sham feeding response of Pavlov pouch dogs, in which gastrin release had been suppressed by total denervation or resection of the antrum, was augmented 4–21 times by i.v. injection of subthreshold amounts of gastrin demonstrating that subthreshold amounts of gastrin potentiated the effect of vagal stimulation of the HCl glands. The sham feeding responses with or without potentation by subthreshold amounts of exogenous gastrin were not inhibited by acidification of totally denervated antral pouches, suggesting that the hypothetical antral chalone does not interfere at the parietal cell level with the cephalic phase of gastric acid secretion.

Inhibition of Gastric Acid Response to Sham Feeding in Pavlov Pouch Dogs by Acidification of Antrum

AbstractThe nervous phase of gastric acid secretion was studied on sham fed Pavlov pouch dogs with an isolated, innervated antrum. The sham feeding response was not inhibited by antral acidification to pH > 2.5. A slight but highly significant inhibition occurred at antral pH 2 and a substantial inhibition at antral pH 1–1.5. The results suggest that on vagal stimulation gastrin is released from the antrum at antral pH ≤ 2 in amounts sufficient to augment significantly the nervous secretory response. Inhibition of the sham feeding response by antral acidification was eliminated by a very low submaximal dose of intravenously administered gastrin in accordance with the hypothesis that depression of vagal release of gastrin is the main inhibitory mechanism elicited by antral acidification during the nervous phase of gastric acid secretion.

Significance of Vagal Release of Gastrin During the Nervous Phase of Gastric Secretion in Dogs

Summary The acid secretory response to sham feeding in Pavlov pouch dogs increased by several hundred per cent following antrumduodenum exclusion. Since pylorotomy did not essentially affect the augmented postexclusion response, regurgitation of duodenal contents into the excluded antrum could not have been an appreciable contributory stimulus. Antral denervation abolished the hypersecretion. On concurrent mechanical stimulation of a denervated antral pouch there was a manifold increase of the sham feeding response, whereas mechanical stimulation of the denervated antrum alone resulted in a liminal or moderate secretion. It is concluded that (1) synergism exists between gastrin and the physiologic vagal excitation of the acid-secreting glands, that (2) vagal release of gastrin from the antrum may cause a manifold increase of the acid secretory response during the nervous phase. The secretory response to insulin hypoglycemia and to sham feeding were determined in the same dogs after the operative measures. The findings demonstrate that the two stimuli in the presence of the antrum similarly reflect the nervous phase of gastric acid secretion. A method for localization of the antrumcorpus boundary during operation is described.

The "combined" operation for peptic ulcer.

In 1953 we published the early results of a "combined" operation for peptic ulcer, comprising partial distal gastrectomy (antrectomy), vagotomy, and gastroduodenal (Billroth I) reconstruction.¹¹Since that time, our experience in the application of this operation has enlarged, and we are now able to provide data on a group of 137 patients treated by this operation, some of whom have been followed for eight years. An increasing number of centers have adopted partial distal gastrectomy and vagotomy as the operation of choice for the treatment of complicated or chronic duodenal ulceration, and their published reports lend ever-increasing support to its worth.^{1,5,7,8, 12-14}The concepts upon which this operation is founded are of both experimental and clinical origin. The importance of the antral and the cephalic phases of gastric acid secretion has been shown experimentally by many investigators, and their laboratory findings have been corroborated by clinical experience.^{2,3,4,13,15,17,18,20}

The Early and Delayed Phases of Gastric Acid Secretion in Response to Insulin Hypoglycemia

The Early and Delayed Phases of Gastric Acid Secretion in Response to Insulin Hypoglycemia

The Early and Delayed Phases of Gastric Acid Secretion in Response to Insulin Hypoglycemia

In a previous communication 1 we reported that duodenal ulcer patients were invariably characterized by sustained gastric acid secretion over a period of 4 hour or longer following insulin stimulation. This response involves an immediate phase (vagal phase) and a delayed phase (pituitary-adrenal phase). In non-ulcer subjects we found two types of responses: one, the sustained response similar to that of duodenal uleer patients, and the other an unsustained response which involved mainly the vagal phase. In this study, we were interested in determining the types of gastrie acid seeretory responses which would follow insulin stimulation in duodenal ulcer patients who had undergone vagotomy with pyloroplasty. The evaluation of methods was similar to that of part I of this artiele. Two sets of data are represented. A set of complete data is represented in terms of an analysis of the pH eurve. Where the exading aspiration teehnique was used, a seeond set of data is represented in terms of milliequivalents of hydrochlorie aeid secretion. As in part I the secretory response is divided into 2 hr. phases, eonsisting of basal seeretion, early phase seeretion and delayed phase secretion. It should be stated that had we not had a large group of patients with vagotomy and pyloroplasty, this study would have been impossible. In our experience, patients having gastroenterostomy or gastrie reseetion give unreliable studies with respect to volumes and pH of gastric secretion, due to the admixture of duodenal and jejunal contents with the gastric aspirates.