Gastric Emptying Function Research Articles

Comprehensive Gastric Emptying Study for Type-II Diabetes Mellitus Dyspeptic Patients

Background: Gastrointestinal symptoms without demonstrable lesions in the upper gastrointestinal tract are common in diabetic patients. Scintigraphic liquid- and solid-phase gastric emptying studies and gastric emptying of indigestible particles were performed to determine the gastric emptying function in type-II diabetes mellitus patients with dyspepsia. Methods: Twenty type-II diabetic patients with symptoms suggestive of delayed gastric emptying were included. A gelatin capsule containing 10 rod-shaped radiopaque markers was ingested, along with the solid-phase test meal, to assess the emptying of indigestible particles. Scintigraphic liquid-phase gastric emptying studies were performed on a separate day. Results: There were 7 patients (35%) with delayed liquid-phase gastric emptying, 14 patients (70%) with delayed solid-phase gastric emptying, and 14 patients (70%) with abnormal gastric emptying of indigestible particles. There were only three patients (15%) with normal gastric emptying of both the liquid and solid phase. Furthermore, only one patient showed normal results in all three gastric emptying studies. Conclusions: For determining abnormalities in gastric emptying function for type-II diabetic dyspepsia patients, comprehensive gastric emptying studies, including scintigraphic liquid- and solid-phase gastric emptying studies and gastric emptying of indigestible particles, are most helpful.

Cholestyramine Influences Meal-Stimulated Pancreaticobiliary Function and Plasma Cholecystokinin Independent of Gastric Emptying and Food Digestion

Background: Cholestyramine enhances gallbladder emptying and plasma cholecystokinin responses to oral ingestion of a mixed meal. It is not known whether this effect occurs independently of alterations in gastric emptying or maldigestion of nutrients. Methods: We perfused 15 g of an amino acid meal intraduodenally for 60min in seven healthy volunteers, once with and once without cholestyramine. Intraduodenal perfusion of saline with or without cholestyramine (6 g/h) was started 60 min before the amino acid meal and continued for 2 h. Results: Cholestyramine markedly enhanced the incremental plasma cholecystokinin response to the meal from 36 ±12 to 139 ± 25 pmol/1 60 min (P < 0.005), incremental amylase output from 2.4 ± 0.7 to 5.7 ± 0.7 kU/h (P < 0.05), and incremental integrated gallbladder contraction from1948 ± 235 to 2840 ± 189% 60 min (P < 0.05). Conclusion: The enhancing effect of cholestyramine on postprandial gallbladder contraction, pancreatic enzyme secretion, and plasma cholecystokinin release is not dependent on gastric emptying rates or appropriate digestion of nutrients.

Gastric emptying and secretory function in the patients with peptic ulcer

Gastric emptying and secretory function in the patients with peptic ulcer