Titanium extraction slag (TES) is a special waste residue in China’s Panxi region. It exhibits low hydration activity because of its high titanium content and carbon- and chlorine-based impurities introduced during production. Thus, TES wastes can only be stored in large quantities. Oil and gas wells’ high-temperature and high-pressure environments contribute to TES hydration. However, its hydration activity should be improved to transform it into a well cementing material. The optimal calcination temperature was 550 ℃. Using NaOH (6 %) as an activator, the compressive strength values of the calcined TES cured for 1 and 14 days reach 19.23 and 34.40 MPa, respectively, 65.49 % and 39.78 % higher than those of untreated TES. These values meet oil and gas well cementing construction requirements. X-ray diffraction, 29Si nuclear magnetic resonance, scanning electron microscopy, and other characterization methods indicate that calcination can reduce the content of the glassy phase in TES. However, it induces impurity removal and reduces the degree of glassy phase polymerization. Thus, TES’s ion leaching and deposition rates, hydration, and compressive strength after calcination improved. Therefore, the method proposed in this study can be successfully used to convert TES into new cementing materials for large-scale applications.