This study investigates the gas–liquid two-phase flow characteristics in a stirred tank equipped with a double-layer punched impeller. Numerical simulations are conducted to analyze flow dynamics, gas holdup, bubble sizes, and distributions under various operational conditions. The results show a high degree of agreement between experimental and simulated power values and gas holdup distributions, validating the reliability of the computational fluid dynamics–population balance model coupling approach. The combination of the punched four-inclined-blade up-pumping turbine and the punched Rushton impeller exhibits excellent bubble dispersion characteristics, with overall small bubble sizes. Increasing the rotational speed can enhance turbulence within the flow field and accelerate the liquid phase velocity, which facilitates gas diffusion and improves gas–liquid mixing efficiency. Additionally, higher rotational speed further intensifies the shear effect of the punched impeller, resulting in a reduction in average bubble size.
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