The seismic response analysis of a 550 kV gas-insulated metal-enclosed transmission line (GIL) is carried out to address the seismic performance issues in the design of the GIL. Firstly, the GIL is modeled in three dimensions, and the pre-stressed modal analysis is conducted to obtain the vibration characteristics of the GIL structure. Secondly, the seismic response spectrum analysis is conducted according to the national standard, and the seismic characteristics are obtained to meet the requirement of resisting an earthquake of magnitude 9, but there are problems of relatively large stress distribution and small safety coefficient of the brace. Finally, it is proposed to change the cross-section of the bracket to strengthen the stiffness of the bracket to improve the seismic performance of the GIL equipment, and simulations are carried out to verify the results, which show that increasing the cross-section of the bracket can improve the seismic performance of the equipment.