Multiphase flow is found in various places in nature and practice. However, multiphase flow is prevalent in the petroleum production industry. This phenomenon gives rise to a significant issue of pressure loss within piping systems, resulting in a loss in production. Multiphase flow has been studied for decades; however, with the increase in unconventional engineering methods, there is now a greater need for its study. This study investigates phenomena related to multiphase flow, such as flow regimes and pressure loss produced by friction, pipe orientation, and various fluid phase properties. An experimental system was designed, and different fluid phases were used to represent varying situations in piping systems. The system included sections of horizontal, inclined, and vertical pipe orientations experienced during hydrocarbon migration from the reservoir to the surface. To replicate industry multiphase flow in the experimental system, we used water to represent the oil and compressed air to represent gas. The pressure differences throughout the system were calculated using the Beggs and Brill Correlation, the Lockhart-Martinelli Parameter, and the Chisholm Equation. Experimental pressure differences and the effect of the choke valve positions were also recorded for the different sections of the system while observing the flow regimes produced by multiphase fluid interaction. Through the research methods, we found that most pressure losses occurred in the elbows, and most frictional pressure loss occurred in the vertical 3ft pipe, while the 45° and 90° downhill pipes experienced increased pressure.