Introduction: Garment factories in India have been playing a vital role in creating employment opportunity for womens. It plays an important role in generating employment opportunities for the rural illiterate women otherwise they had to work as maid servant. Garment sector opened a new door for rural people to engage themselves into the economic activities. Due to the physical demands and the repetitive nature of their work, factory workers are susceptible to musculoskeletal disorders, pain in the back and large joints such as the knee and shoulder joints are among the most common health complaints in industrialized societies. These problems are even more common among females and older workers. The aim of this study was therefore to assess the nature and extent of health problems and the quality of life experienced by female garment workers in Tumkur. Methodology: A cross-sectional survey was conducted among women working in garment factory . The survey included three questionnaires. A self-administered questionnaire will be used to collect data on quality of life using World Health Organization Quality of Life Brief questionnaire (WHO QOL) .GHQ 28 Questionnaire will be used to asses Physical health status of the study subjects. Data were coded and entered into SPSS version22. After data cleaning and checking, tabulations were carried out using SPSS version22 in order to describe the population and the prevalence of the conditions of interest. Results: Out of 162 38(23.4%) had Back pain, 20(12.3%) had gastric pain,8(4.9%) had dermatitis. 14(8.6%) had Joint Pain,8(4.9%) had Problems related to bones, 4(2.5%) had skin allergies, 68(41.9%) had tension headache, 68(41.9%) had Poor Quality of life, 94(58.0%) had good Quality of life. Conclusion: Female garment workers reported overall good health; their most notable problem was musculoskeletal symptoms. The findings could represent adequate control of work-related risks.Around 58 % had good quality of life .