Abstract Fault zones along active tectonic block boundaries are a significant source of devastating continental earthquakes. Strong earthquakes produce disruptions of sediment and induce characteristic sediments near the fault, which serve as valuable sedimentary evidence for identifying and dating of paleoearthquakes. In this study, we aimed to reconstruct the earthquake history of the Qilian–Haiyuan fault zone in the northeastern Tibetan Plateau during the Holocene. We reanalyzed forty-four trenches and used the sedimentary sequences, event indicators, and age constraints to determine the earthquake history. Our analysis revealed the paleoearthquakes of 6 subsidiary faults of the Qilian–Haiyuan fault zone with accurate event ages and rupture extents. Based on the spatial and temporal distributions of strong earthquakes since 10 ka, we identified five earthquake clusters around the central-eastern Qilian–Haiyuan fault zone including seven rupture cascades where the earthquakes migrated gradually from east to west. The existing seismic gap reveals that the latest migration may not yet be complete and suggests a high probability of M ≥ 7 earthquakes occurring on the Jinqianghe fault, Maomaoshan fault, and the central part of the Lenglongling faults. We concluded that, in order to better understand earthquake cycles and seismic hazards, it is important to consider a fault zone as a whole, including multiple faults and their interaction on the earthquake triggering between nearby faults.