Groundwater Storage (GWS) is an important component of the water cycle and a vital resource for supplying water to millions of people as well as sustaining domestic and economic activities, especially in arid and semi-arid regions such as Africa. This study aims to estimate and analyze the recent groundwater changes (ΔGW) for 11 major African basins in light of climate changes and global warming utilizing the data from the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On (GRACE-FO) from January 2003 to December 2021. We proposed a new gap-filling technique to calculate the missing months between GRACE and GRACE-FO missions for the continuous estimation of groundwater changes. Then, we establish a new framework to analyze and investigated the climate parameters that could affect groundwater changes using Empirical Orthogonal Function (EOF) technique. Our analysis reveals that the new gap-filling technique is significantly consistent with the TWS time-series based on the trend line analysis. The lowest GPCC drought index value occurs in the lower Nile basin by approximately −0.93, while the highest occurs in the middle of Africa in Congo basin by approximately −0.02. The precipitation rate is mostly concentrated in mid-Africa while North and South Africa shows a weak rate. Meanwhile, according to the analysis of dependent climate parameters, climate change has had a negative impact on groundwater. However, the long-term effect on the groundwater does not clearly appear because most of Africa is located within semi-arid and arid regions. The effect of rain on groundwater was evident through EOF analysis, which shows GWS EOF Mode-2 (36.28%) and precipitation EOF Mode-1 (78.34%) were found to be in significant agreement in spatio-temporal domains.
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