Gap Detection Ability Research Articles

Behaviorally measured audiograms and gap detection thresholds in CBA/CaJ mice

Tone detection and temporal gap detection thresholds were determined in CBA/CaJ mice using a Go/No-go procedure and the psychophysical method of constant stimuli. In the first experiment, audiograms were constructed for five CBA/CaJ mice. Thresholds were obtained for eight pure tones ranging in frequency from 1 to 42 kHz. Audiograms showed peak sensitivity between 8 and 24 kHz, with higher thresholds at lower and higher frequencies. In the second experiment, thresholds for gap detection in broadband and narrowband noise bursts were measured at several sensation levels. For broadband noise, gap thresholds were between 1 and 2 ms, except at very low sensation levels, where thresholds increased significantly. Gap thresholds also increased significantly for low pass-filtered noise bursts with a cutoff frequency below 18 kHz. Our experiments revised absolute auditory thresholds in the CBA/CaJ mouse strain and demonstrated excellent gap detection ability in the mouse. These results add to the baseline behavioral data from normal-hearing mice which have become increasingly important for assessing auditory abilities in genetically altered mice.

Age-related changes in glycine receptor subunit composition and binding in dorsal cochlear nucleus

Age-related hearing loss, presbycusis, can be thought of, in part, as a slow progressive peripheral deafferentation. Previous studies suggest that certain deficits seen in presbycusis may partially result from functional loss of the inhibitory neurotransmitter glycine in dorsal cochlear nucleus (DCN). The present study assessed age-related behavioral gap detection changes and neurochemical changes of postsynaptic glycine receptor (GlyRs) subunits and their anchoring protein gephyrin in fusiform cells of young (7–11 months) and aged (28–33 months) Fischer brown Norway (FBN) rats. Aged rats showed significantly (20–30 dB) elevated auditory brainstem-evoked response thresholds across all tested frequencies and worse gap detection ability compared to young FBN rats. In situ hybridization and quantitative immunocytochemistry were used to measure GlyR subunit message and protein levels. There were significant age-related increases in the α 1 subunit message with significant age-related decreases in α 1 subunit protein. Gephyrin message and protein showed significant increases in aged DCN fusiform cells. The pharmacologic consequences of these age-related subunit changes were assessed using [ 3H] strychnine binding. In support of the age-related decrease of α 1 subunit protein levels in DCN, there was a significant age-related decrease in the total number of GlyR binding sites with no significant change in affinity. These age-related changes may reflect an effort to reestablish a homeostatic balance between excitation and inhibition impacting on DCN fusiform cells by downregulation of inhibitory function in the face of an age-related loss of peripheral input. Age-related decrease in presynaptic glycine release results in altered subunit composition and this may correlate with loss of temporal coding of the aged fusiform cell in DCN. The previously reported role for gephyrin in retrograde intracellular receptor subunit trafficking could contribute to the α 1 decrease in the face of increased message.

Widespread Auditory Deficits in Tune Deafness

The goal of this study was to investigate auditory function in individuals with deficits in musical pitch perception. We hypothesized that such individuals have deficits in nonspeech areas of auditory processing. We screened 865 randomly selected individuals to identify those who scored poorly on the Distorted Tunes test (DTT), a measure of musical pitch recognition ability. Those who scored poorly were given a comprehensive audiologic examination, and those with hearing loss or other confounding audiologic factors were excluded from further testing. Thirty-five individuals with tune deafness constituted the experimental group. Thirty-four individuals with normal hearing and normal DTT scores, matched for age, gender, handedness, and education, and without overt or reported psychiatric disorders made up the normal control group. Individual and group performance for pure-tone frequency discrimination at 1000 Hz was determined by measuring the difference limen for frequency (DLF). Auditory processing abilities were assessed using tests of pitch pattern recognition, duration pattern recognition, and auditory gap detection. In addition, we evaluated both attention and short- and long-term memory as variables that might influence performance on our experimental measures. Differences between groups were evaluated statistically using Wilcoxon nonparametric tests and t-tests as appropriate. The DLF at 1000 Hz in the group with tune deafness was significantly larger than that of the normal control group. However, approximately one-third of participants with tune deafness had DLFs within the range of performance observed in the control group. Many individuals with tune deafness also displayed a high degree of variability in their intertrial frequency discrimination performance that could not be explained by deficits in memory or attention. Pitch and duration pattern discrimination and auditory gap-detection ability were significantly poorer in the group with tune deafness than the normal control group. Approximately one-third of our participants with tune deafness displayed evidence of attention deficit with hyperactivity disorder on the Test of Variables of Attention. Test of Variables of Attention scores were significantly correlated with gap-detection scores, but not significantly correlated with any of the other experimental measures, including the DTT, DLF, and auditory pattern discrimination tests. Short- and long-term memory was not significantly related to any of the experimental measures. Individuals with tune deafness identified by the DTT have poor performance on many tests of auditory function. These include pure-tone frequency discrimination, pitch and duration pattern discrimination, and temporal resolution. Overall, reduction in performance does not seem to derive from deficits in memory or attention. However, because of the prevalence of attention deficit with hyperactivity disorder in those with tune deafness, this variable should be considered as a potentially confounding factor in future studies of tune deafness and its characteristics. Pure-tone frequency discrimination varied widely in individuals with tune deafness, and the high degree of intertrial variability suggests that frequency discrimination may be unstable in tune-deaf individuals.

Auditory gap detection in the early blind

For blind individuals, audition provides critical information for interacting with the environment. Individuals blinded early in life (EB) typically show enhanced auditory abilities relative to sighted controls as measured by tasks requiring complex discrimination, attention and memory. In contrast, few deficits have been reported on tasks involving auditory sensory thresholds (e.g., Yates, J.T., Johnson, R.M., Starz, W.J., 1972. Loudness perception of the blind. Audiology 11(5), 368–376; Starlinger, I., Niemeyer, W., 1981. Do the blind hear better? Investigations on auditory processing in congenital or early acquired blindness. I. Peripheral functions. Audiology 20(6), 503–509). A study of gap detection stands at odds with this distinction [Muchnik, C., Efrati, M., Nemeth, E., Malin, M., Hildesheimer, M., 1991. Central auditory skills in blind and sighted subjects. Scand. Audiol. 20(1), 19–23]. In the current investigation we re-examined gap detection abilities in the EB using a single-interval, yes/no method. A group of younger sighted control individuals (SCy) was included in the analysis in addition to EB and sighted age matched control individuals (SCm) in order to examine the effect of age on gap detection performance. Estimates of gap detection thresholds for EB subjects were nearly identical to SCm subjects and slightly poorer relative to the SCy subjects. These results suggest some limits on the extent of auditory temporal advantages in the EB.

Auditory processing deficits in a teenager with Landau-Kleffner syndrome

This study explores the auditory processing skills of a 14-year-old boy (William) with an acquired aphasia, diagnosed as Landau-Kleffner syndrome. A single case study design was implemented, with the use of both chronological age-matched and receptive-language-matched control participants. Tasks were designed to investigate non-linguistic and linguistic auditory processing. The results indicated that William had intact peripheral hearing and gap detection abilities. However, William was significantly impaired at detecting a tone presented before or during some masking noise. William also showed significant impairments in three auditory processing tasks, requiring discrimination of both word and non-word stimuli. Findings suggest that William has an auditory processing deficit affecting the perception and discrimination of linguistic and some non-linguistic stimuli.

Effects of bilateral auditory cortical lesions on gap-detection thresholds in the ferret (Mustela putorius).

Ferrets were tested for their ability to detect temporal gaps in noise before and after bilateral lesions of the primary auditory cortex. Thresholds for gap detection were determined first for normal animals with band-pass noises at various center frequencies (0.5 to 32 kHz) and at 8 kHz with various sound pressure levels (-10-70 dB). Gap-detection ability improved steadily as sound pressure increased up to 70 dB. No systematic relation was found between threshold and center frequency. To determine the effects of brain damage, ferrets were tested with 8-kHz band-pass noise at 70 dBSPL. After bilateral lesions of auditory cortex, ferrets were still capable of detecting gaps, but the mean threshold was elevated from 10.1 to 20.1 ms. The data demonstrate that auditory cortex is important for perceptual tasks requiring fine temporal resolution.

The effect of intensity on gap detection in hearing-impaired listeners

Previous investigations of gap detection by hearing-impaired listeners have yielded results that are inconsistent across listeners and studies. The full effect of stimulus intensity and audibility on hearing-impaired listeners’ performance has not been described. This study investigated the effect of intensity on gap detection abilities of normal-hearing listeners and listeners with similar mild to moderate high-frequency hearing impairments. Listeners were required to detect a gap in a high-frequency narrow-band noise over a wide range of intensities above threshold, and to judge the loudness of the signal. Results indicated that at low intensities all listeners showed reduced gap detection ability. As intensity increased, the listeners’ performance improved and stabilized at high sensation levels. At these higher intensities, the performance of hearing-impaired listeners was similar to, but still significantly different from that of normals (mean group difference=1 ms). This difference in listeners’ performance was found when results were compared in sensation level, sound-pressure level, and loudness. Consistent results across eight hearing-impaired listeners suggested that ensuring full audibility of the stimulus yields more consistent performance. These results suggest that temporal resolution ability is affected by both hearing impairment and by stimulus intensity.

A Psychoacoustic and Electrophysiological Study

von Wedel H, von Wedel U—Ch, Streppel M. Monaural and binaural time resolution ability in the aged; A psychoacoustic and electrophysiological study. Acta Otolaryngol (Stockh) 1991; Suppl. 476: 161—166.Time resolution ability is an important factor of auditory processing, especially in binaural hearing. In psychoacoustical and electrophysiological studies the time resolution of brief modulations of signal amplitude and frequency in monaural hearing, including gap detection ability, was analysed. To reveal the time resolution ability of the binaural hearing system, brief interaural modulations of signal amplitude, short changes of interaural time delay or noise coherence in broadband noise bursts were generated. The sensation levels of these short—lasting changes in the noise structure and the cortical evoked potentials were investigated in young normal hearing subjects and in the elderly. Thus age—dependent changes in monaural and binaural time resolution ability could be detected. For the monaural experiments, lengthened time constants of between 2—20 ms, depending on the degree of intensity or frequency modulation could be derived for older subjects. The binaural experiments were characterized by prolongation between 4—26 ms for short interaural signal delay changes. For both groups the time constants derived from the electrophysiological investigations were more prolonged, which might be explained by masking effects or habituation. Further electrophysiological investigations will be required to differentiate between time resolution processes of brief signal changes within the peripheral and central parts of the auditory system.