Objective. A scintillator is a luminescent material that converts high-energy photons into visible light and is widely used in medical imaging. Different scintillators are applied to gamma imaging in proton therapy and boron neutron capture therapy (BNCT). A pixelated scintillator is suitable for position measurement. The energy resolution, detection efficiency and position measurement of pixelated scintillators coupled to a SiPM were investigated via two kinds of detectors. The goal of this manuscript was to accurately measure the gamma source position through spectrum analysis in selection of energy windows for characteristic gamma lines. Approach. Scintillators were effectively manufactured and encapsulated before testing, especially for the easily deliquescent LaBr3. The compact front-end electronic prototype modules with 2 × 2 array SiPMs in stacked form and 1 × 10 array SiPMs in parallel form were developed for gamma ray energy resolution and efficiency measurements with a radioactive source of 22Na, which had two energy gamma lines at 511 keV and 1274 keV. Energy calibration was used for accurate energy window selection when measuring the position of the gamma source. Main results. Evident inconsistencies were present between different pixels of the same type of scintillator. Thus, an energy calibration method was needed. LaBr3 was the first candidate scintillator for the gamma ray spectrum measurement since it exhibited the best performance with an energy resolution of ∼5%. The recommended size of LaBr3 was 5 × 5 mm2, which had a higher efficiency than the 3 × 3 mm2 size. The gamma count of the multiple mode of the 2 × 2 array was much higher than that of the single mode, while the energy resolution was poorer. Thus, multiple mode was not suitable for gamma ray detection. The 1 × 10 array detector had the potential to measure the gamma ray source position and could be used for proton therapy and BNCT. A small deviation of 0.22 cm was observed in the measurement of the source center position with Energy Window 1 for 511 keV and Energy Window 2 for 1274 keV before the energy calibration. No deviation was observed after energy calibration. Thus, to achieve a higher accuracy position measurement, automatic energy calibration algorithm was coded into data acquisition software. Significance. The characteristic gamma lines produced by particle therapy are abundant and useful for imaging technology. Our developed compact pixelated scintillator detector coupled with SiPMs could measure the gamma spectrum with high resolution. The energy calibration and window selection method could measure the position of the source with high accuracy. Therefore, an advanced imaging device based on the energy spectrum for particle therapy could be potentially attainable.
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