ABSTRACT Responsible Gambling/Harm Minimization (RG/HM) measures have the potential to reduce population level gambling harms. The present study examines Canadian casino electronic gaming machine (EGM) players’ (n = 2808) awareness of a selection of the available RG/HM measures, and the impact they believed these measures had on their gambling expenditure and enjoyment. The results showed that Canadian casino EGM players were generally aware of most of the measures, with this awareness being significantly higher among at-risk and problem/pathological gamblers. However, these measures had very little perceived impact on their gambling expenditure or enjoyment. Subsequent multivariate analyzes found that a) increased levels of overall awareness of RG/HM measures were related to male gender, younger age, and higher importance of gambling as a leisure activity; b) that decreased perceived expenditure from RG/HM measures were related to younger age, being an at-risk gambler, and the frequency of limit setting in the context of gambling play; and c) increased perceived enjoyment from RG/HM measures were related to lower household incomes. Messages targeted at Canadian casino EGM players who appear sensitive to the potential and actual harms of gambling, and messages relating to limit setting frequency in the context of gambling play, may impact gambling perceptions.