This paper presents GAFEE instructional design: a new proposed model that integrates the principles of gamification with the 5E instructional model to increase the levels of motivation of the students. The GAFEE model blends the five phases of 5E learning model Engage, Explore, Explain, Elaborate, and Evaluate with a game-based approach that increases the level of interactivity. This model comprises seven constructs: According to the nature of the problem and the design principles, we have Goal-Oriented Engagement, Autonomous Access and Exploration, Feedback-Enhanced Explanation, Challenge-Driven Elaboration, Collaborative Evaluation, Iterative Design and Technological Synergy. Each of the identified constructs is backed up by a literature review proving the efficiency of the given construct. An example of the implementation of the GAFEE model is best described in a fourth-grade English course where the students’ vocabulary, grammar, and speaking skills are enhanced. These points stress the positive outcome of the application of the game environment to the educational process, motivation, individual learning, and feedback systems. Lastly, the paper highlights on the effectiveness of the proposed GAFEE instructional design to alter the instructional practices and point out the areas of future research in gamification of education.