Carcinosarcoma Of Gallbladder Research Articles

Morphologic Heterogeneity in Carcinosarcoma of the Gallbladder: Report of a Rare Cases

Carcinosarcoma is a rare tumor composed of variable proportions of carcinomatous and sarcomatous elements and comprises less than one percent of all gallbladder malignancies. In most reported cases of carcinosarcoma of gallbladder, the epithelial component is adenocarcinoma. The mesenchymal component varies from homogenous sarcoma to more heterotopic elements like malignant bone, cartilage, and other mesenchymal tissues. We report a rare case of carcinosarcoma of the gallbladder in an 83-year-old male, with the carcinomatous component represented by undifferentiated carcinoma (spindle and giant cell type with osteoclastic giant cells) and the mesenchymal component seen as foci of chondrosarcoma.

Carcinosarcoma of the Gallbladder Arising in a Patient with Pancreaticobiliary Maljunction: A Case Report and Review of the Literature

Background: Carcinosarcoma of the gallbladder is a very uncommon malignancy. We present a case of gallbladder carcinosarcoma arising in a 38-year-old female patient with pancreaticobiliary maljunction where FNA documented recurrence of this very unusual tumor. Case: A 38-year old woman presented with signs and symptoms of acute pancreatitis due to gallstones (biliary pancreatitis) Further investigations, including abdominal ultrasonography and endoscopic retrograde cholangiopancreatography (ERCP), revealed an ill-defined mass in the gallbladder, in addition to pancreaticobiliary maljunction. At laparoscopic cholecystectomy, a mass was found within the gallbladder lumen itself. A biphasic malignant neoplasm was diagnosed in a free lying, polypoid mass within the gallbladder lumen. This carcinosarcoma was considered to have been locally confined to the gallbladder, equivalent to a stage T1a, and further surgery was not undertaken. The patient re-presented under a year later with dyspnoea; and a large subdiaphragmatic mass was noted that underwent ultrasound-guided fine needle aspiration (FNA) biopsy. The cytomorphologic findings showed a tumor comprising malignant glandular structures and pleomorphic stromal cells in a metachromatic background, compatible with the previous diagnosis of carcinosarcoma. Conclusion: Carcinosarcomas are uncommon malignancies and can arise in almost any site where carcinomas arise. Careful attention to morphology will allow the biphasic nature of this lesion to be determined but ancillary investigations may be required. Carcinosarcoma is a biphasic malignant neoplasm with both malignant epithelial (carcinomatous) and stromal (sarcomatous) elements. Carcinosarcoma occurring in the gallbladder is a rare malignancy of which there have been fewer than seventy reports in the worldwide literature to date, with thirty two of these in the English literature [1-14]. We present a case of gallbladder carcinosarcoma in a young patient with pancreaticobiliary maljunction, treated with cholecystectomy, with subsequent local recurrence diagnosed on image-guided fine needle aspirate (FNA). There appears to be only one other reported case of FNA of a carcinosarcoma of the gallbladder in which an initial diagnosis of a high-grade spindle cell sarcoma was made cytologically.

Clinicopathologic features of gallbladder carcinosarcoma - adenocarcinoma and angiosarcoma

Clinicopathologic features of gallbladder carcinosarcoma - adenocarcinoma and angiosarcoma

Fibroadenoma of the gallbladder with borderline malignancy: a poorly recognized gallbladder tumor

Fibroadenoma of the gallbladder is extremely rare tumor, with only two cases reported in the world. It is characterized by abundant loose edematous connective tissue, glandular structure, polypoid structure covered by epithelia, and a filamentous pedicle. We report a case of 78-year-old woman histopathologically diagnosed after surgery. Macroscopically, the tumor was a dark-greenish solid mass with a short stalk, filling the gallbladder cavity, and it measured 11.5 x 4.0 x 3.5 cm in diameter. Microscopically, the tumor was composed of abundant loose stroma and a glandular component. Some of the glandular cells had hyperchromatic nuclei with disturbed polarity and were positively stained by p53 (30%) and Ki-67 (30-40%). Part of the stromal component revealed hypercellularity with an irregular nucleus, mitosis (2-3 cells/10 high-power fields), and positivity for Ki-67 (20%) and p53 (50%). We diagnosed this peculiar tumor as "fibroadenoma of the gallbladder with borderline malignancy". We present the details of this extremely rare case and discuss the pathological findings, comparing them to those in the two previously reported cases and to carcinosarcoma of gallbladder.

Carcinosarcoma of the gallbladder: Report of a case

Gallbladder carcinosarcoma is one of the rarest subsets of gallbladder malignancies. To date, only 34 cases have been reported in the English literature. Therefore the knowledge and experience regarding this disease is limited. This report describes a 70-year-old male patient who was diagnosed by documenting the epithelial and mesenchymal components with histopathological and immunohistochemical methods, and treated by a radical cholecystectomy. The pediculated polypoid tumor had filled the lumen, originating from the gallbladder fundus. The tumor infiltrated the surrounding connective and adipose tissue overlapping the muscular layer of its primary site, but had not perforated the serosa nor invaded the liver. The patient, who was treated only surgically, has remained healthy after 54 months of follow-up, which is the longest documented survival for this disease. This case indicates that curative treatment of a tumor confined to the gallbladder without liver or serosa invasion, or lymph node involvement, is therefore possible.

Clinicopathologic features of gallbladder carcinosarcoma

Clinicopathologic features of gallbladder carcinosarcoma

Carcinosarcoma of gallbladder: A case report

Carcinosarcoma is a rare entity of neoplasm especially in gallbladder, with collision elements of both adenocarcinomatous and sarcomatous component. Its clinical behavior is even worse than that of carcinoma, yet few cases have been reported to date. A male patient 75 years old admitted in our hospital was finally diagnosed as carcinosarcoma. He underwent surgical resection and adjuvant chemotherapy with oxaliplatin-containing regimen for six cycles. The patient achieved a long-time survival of 30 months.

Gallbladder Carcinosarcoma: A Case Report and Literature Review

Carcinosarcoma of the gallbladder is a rare malignancy characterized by both malignant epithelial and mesenchymal components. The clinical behavior of this tumor is extremely aggressive. Only 26 cases have been reported in the world literature to date. We report the case of a 64-year-old woman who had fever associated with a right upper quadrant mass. An exploratory laparotomy through a right upper quadrant incision was performed at another institution, and the patient was thought to have severe acute cholecystitis that would require additional antibiotic therapy before attempted resection. She was referred to our center, where abdominal CT showed a 6.4 x 8.2 cm pericholecystic mass involving the hepatic flexure of the colon. The patient underwent cholecystectomy and hepatic wedge resection, pancreaticoduodenectomy, and right hemicolectomy. Pathologic examination of the surgical specimen revealed two histologic components consisting of squamous cell carcinoma and spindle cell sarcoma of gallbladder origin, consistent with carcinosarcoma. All seven lymph nodes in the pancreaticoduodenectomy specimen were negative for tumor. We present this case and a review of the literature and current treatment recommendations.

長期生存中の胆嚢癌肉腫の1例

長期生存中の胆嚢癌肉腫の1例

Clinicopathological study of so-called carcinosarcoma of gallbladder

Clinicopathological study of so-called carcinosarcoma of gallbladder

軟骨形成を伴う胆嚢癌肉腫の１例

軟骨形成を伴う胆嚢癌肉腫の１例

胆嚢癌肉腫のｌ例

症例は69歳の男性. 主訴は右季肋間痛. 他院のCTにて胆嚢腫瘤を指摘され当院に紹介入院となった. 当院の超音波検査では胆嚢底部に径30mmの内部エコー不均一な腫瘤を認めた. 胆嚢悪性腫瘍の診断で胆摘, 肝床切除郭清術を施行. 病変は30×20×25mm大で, 胆嚢底部肝床側原発の腫瘤性病変であり, 病理組織学的検索にて横絞筋肉腫と腺癌からなる胆嚢癌肉腫と診断された. 術後4年9カ月経過した現在現発の兆候を認めていない.