Space medicine is a branch of aerospace medicine, which is a crucial field, albeit with minimal research. Research at the International Space Station and other endeavors has provided insights into how loss of gravity could affect the physiological functions of humans. Organs such as the heart could begin to deteriorate with lack of resistance from the planet. The musculoskeletal system, which is the anatomical backbone, may struggle to support the individual’s structure. The cardiovascular system will be inefficient with respect to circulation, leading to other organ dysfunction. Radiation in space, also known as cosmic radiation, is caused by many different celestial bodies such as stars, sun, supernovae, and black holes. The Earth’s magnetic field is a crucial component to protect humans from harmful radiation. However, once humans venture beyond the protective confines, the body becomes exposed to dangerous elements that pose a significant threat to safety. Living in microgravity also has detrimental effects on organisms’ brains. These include but are not limited to sustained effects on circadian rhythm, emotional dysregulation, and cognitive dysfunction. This article discusses the threat of premature aging during long- and short-term times in space due to high risks associated with space travel. Improvement of clinical intervention is hindered by a lack of research and development, which is needed to fundamentally address these risks.