Understanding the flow field developed in the proximity of a building due to the wind flow over it is a prerequisite for designing a building. The wind environment around buildings plays a pivotal role not only from the point of view of structural integrity but also impacts the ventilation performance, pedestrian comfort and dispersion of pollutants. With the emergence of the green building concept in the light of the sustainable living, modern buildings are equipped with various openings such as doors, windows and ventilators. These openings change the flow characteristics in and around the building remarkably and make the flow field much more complex. The current study seeks to improve the understanding of both the internal and external flow fields around the buildings with openings. In this work, an attempt has been made to investigate the influence of wind direction on the flow behavior of wind in and around gable roof buildings with six different opening configurations. Commercially available CFD software ANSYS-FLUENT is used for numerical simulations. The numerical simulations are carried out to solve the steady Reynolds Averaged Navier Stokes (RANS) equations. The results obtained from the numerical simulations are validated with the previously published experimental results, and a good agreement was observed.