According to the latest global cancer statistics for 2022, liver cancer ranks as the ninth most common disease in women. Segmenting the liver and distinguishing it from tumors within it pose a significant challenge due to the complex nature of liver imaging. Common imaging methods such as Magnetic Resonance Imaging (MRI), Computer Tomography (CT), and Ultrasound (US) are employed to distinguish liver tissue from liver tumors after collecting a sample. Attempting to partition the liver and tumor based on grayscale shades or shapes in abdominal CT images is not ideal because of the overlapping intensity levels and the variability in the location and shape of soft tissues. To address this issue, this study introduces an effective method for liver image segmentation using a 3D deep Convolutional Neural Network (3D-DCNN). The process involves several stages. First, liver images undergo preprocessing to enhance image quality, including median filtering, adaptive filtering, and converting them to grayscale. The feature extraction phase focuses on extracting four sets of features, such as the Local Binary Pattern (LBP) and the Gray-Level Co-occurrence Matrix (GLCM). Additionally, an Iterative Region Growing (IRG) technique is developed to improve the Dice Similarity Coefficient (DSC) prediction by enhancing the quality of the input images obtained from segmented images. This method enables the segmentation of the liver in abdominal CT image volumes and can subsequently be used to segment liver tumor images to evaluate the performance of the proposed 3D-DLNN approach. This method was implemented in MATLAB, and its performance was evaluated using various metrics. In experimental analysis, the proposed technique outperformed other methods, including Jaccard with JISTS-FCM, Fuzzy C-Means (FCM), and FCM with Cluster Size Adjustment (FCM-CSA).
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