This study introduces the novel Fuzzy-Enhanced Predictive Neural System for Student Mental Health (FEPS-MH) approach to mental health assessment and intervention for college students. FEPS-MH synergistically combines a Backpropagation (BP) Neural Network with a Deep Fuzzy-Based Neural Network (DFBNN), leveraging the strengths of both systems to handle the complexities of mental health data in the context of big data analytics. The BP Neural Network, known for its effective learning and generalization capabilities, is integrated with the DFBNN to process imprecise, uncertain, or subjective data, typical in mental health assessments. The core objective of FEPS-MH is to provide a more accurate, robust, and sensitive analysis of mental health states, incorporating the nuanced variations and uncertainties inherent in psychological data. This system is designed to analyze a vast array of data sources, including but not limited to, behavioral patterns, self-reported questionnaires, and social media interactions, to identify potential mental health issues among college students. FEPS-MH’s capabilities extend beyond mere assessment; it is also equipped to recommend personalized intervention strategies. Utilizing big data analysis, the system not only predicts potential mental health crises but also suggests tailored intervention approaches based on the unique psychological profile of each student. This study demonstrates the feasibility and effectiveness of FEPS-MH through a series of tests and validations using real-world data. The results indicate a significant improvement in both the accuracy of mental health assessments and the efficacy of suggested interventions. FEPS-MH stands as a promising tool for educational institutions, offering a data-driven, sensitive, and comprehensive approach to student mental health care. Its implementation could revolutionize the field of mental health support in college environments, making it a vital asset for proactive psychological wellness in educational settings.