Futuristic Approach Research Articles

System of Wheat Intensification: An Innovative and Futuristic Approach to Augment Yield of Wheat Crop

There is a new method of wheat production called the System of Wheat Intensification (SWI) that manages seed treatment, seed rate, spacing, weeding, and watering. The SWI and traditional methods of wheat sowing differ from each other in terms of potential yield. In comparison to the traditional method of wheat sowing, SWI allows seed treatment, which increases the number of tillers, the number of grains in spike, and the weight of the grain. Wheat seeding in the traditional approach is done at a much closer distance than in the SWI method, which results in faulty germination as a result of increased competition between the plants. In SWI, proper root formation in the early stages of crop growth can be encouraged by increasing the space between plants and rows, as well as increasing the density of plants. For small and medium-sized farmers, it is a great way to boost productivity and income while reducing food poverty at the same time. Using organic manure instead of chemical fertilizer is a new strategy that helps support sustainable agriculture. To help the poorest farmers and enhance their productivity and profit, SWI should be recommended.

Inaugurated Eschatology within South African Pentecostalism

Abstract Pentecostal eschatology differs from one sub-tradition of Pentecostalism to the other in a South African context. Sub-traditions such as classical Pentecostalism and the New Prophetic Churches (npc s) have been engaged in more than one form of eschatology. The differences are explored here to understand their implications for Pentecostal eschatology. The Pentecostal prophets in npc s do not exclusively focus on a futuristic eschatological approach as opposed to classical Pentecostalism. Pentecostal prophets in npc s embrace a realised eschatology of the kingdom in the here and the now. The challenge is that this approach presents some form of abuse in these churches. How do we address these abuses emanating from an overemphasised realised eschatology? How do we deal with the tensions between realised eschatology and futuristic eschatology? What could be the relevant eschatology that balances both extremes of a futuristic eschatology and realised eschatology? These questions are addressed here through an inaugurated eschatology.

Deciphering agr quorum sensing in Staphylococcus aureus: insights and therapeutic prospects.

The emergence of superbugs like methicillin-resistant Staphylococcus aureus exposed the limitations of treating microbial infections using antibiotics. At present, the discovery of novel and convincing therapeutic methods are being executed increasingly as possible substitutes to conventional antibiotic therapies. The quorum sensing helps Staphylococcus aureus become more viable through their signaling mechanisms. In recent years, targeting the prominent factors of quorum sensing has obtained remarkable attention as a futuristic approach to dealing with bacterial pathogenicity. The standard antibiotic therapy intends to inhibit the organism by targeting specific molecules and afford a chance for the evolution of antibiotic resistance. This prompts the development of novel therapeutic strategies like inhibiting quorum sensing that can limit bacterial virulence by decreasing the selective pressure, thereby restricting antibiotic resistance evolution. This review furnishes new insights into the accessory gene regulator quorum sensing in Staphylococcus aureus and its inhibition by targeting the genes that regulate the operon. Further, this review comprehensively explores the inhibitors reported up to date and their specific targets and discusses their potentially ineffective alternative therapy against methicillin-resistant Staphylococcus aureus.

Concept and Evolution in 3-D Printing for Excellence in Healthcare.

Three-dimensional printing (3DP) has gained popularity among scientists and researchers in every field due to its potential to drastically reduce energy costs for the production of customised products by utilising less energy-intensive machines as well as minimising material waste. The 3D printing technology is an additive manufacturing approach that uses material layer-by-layer fabrication to produce the digitally specified 3D model. The use of 3D printing technology in the pharmaceutical sector has the potential to revolutionise research and development by providing a quick and easy means to manufacture personalised one-off batches, each with unique dosages, distinct substances, shapes, and sizes, as well as variable release rates. This overview addresses the concept of 3D printing, its evolution, and its operation, as well as the most popular types of 3D printing processes utilised in the health care industry. It also discusses the application of these cutting-edge technologies to the pharmaceutical industry, advancements in various medical fields and medical equipment, 3D bioprinting, the most recent initiatives to combat COVID-19, regulatory frameworks, and the major challenges that this technology currently faces. In addition, we attempt to provide some futuristic approaches to 3DP applications.

Potential role of microRNAs in personalized medicine against hepatitis: a futuristic approach.

MicroRNAs (miRNAs) have been the subject of extensive research for many years, primarily in the context of diseases such as cancer. However, our appreciation of their significance in viral infections, particularly in hepatitis, has increased due to the discovery of their association with both the host and the virus. Hepatitis is a major global health concern and can be caused by various viruses,including hepatitis A to E. This review highlights the key factors associated with miRNAs and their involvement in infections with various viruses that cause hepatitis. The review not only emphasizes the expression profiles of miRNAs in hepatitis but also puts a spotlight on their potential for diagnostics and therapeutic interventions. Ongoing extensive studies are propelling the therapeutic application of miRNAs, addressing both current limitations and potential strategies for the future of miRNAs in personalized medicine. Here, we discuss the potential of miRNAs to influence future medical research and anattempt to provide a thorough understanding of their diverse roles in hepatitis and beyond.

Tree tomato: Underutilized vegetable for sustainable nutritional and economic security

Tree tomato is an underutilized high-value vegetable possessing high functional value to satisfy the needs of health-conscious people. Its fruits contain a diverse range of nutrients and bioactive compounds including vitamins, minerals, dietary fibers, polyphenols, anthocyanin, and carotenoids possessing potent nutraceutical properties. The presence of a wide range of bioactive compounds makes the fruits excellent antioxidative, antiproliferative, anti-inflammatory, and anti-obese food constituents. The crop has not yet been explored to full of its potential. Germplasm conservation strategies, hybridization, micropropagation, polyploidy, genetic engineering, genome editing etc. have been successfully utilized for the development of cultivars with improved traits in many crops and can be of help for the potential improvement of tree tomatoes. Nowadays, the changing food consumption patterns have resulted in an increased interest in the consumption of tree tomatoes. Advanced technologies for the development of value-added products with minimized losses, enhanced stability and bioavailability of bioactive compounds, and optimization of processes to preserve the functionality of the product need the attention of the scientific community. This paper summaries the functional characterization of major bioactive compounds, improvement strategies, and the effect of processing on quality traits along with futuristic approaches for the potential improvement of tree tomatoes.

Sketching feasibility of additively manufactured different size gradient conventional hollow capsular shells (HCSs) by selective laser sintering (SLS): From design to applications

Additive manufacturing (AM) is widely used to fabricate 3D printed objects from Computer-aided Design (CAD) prepared using the SolidWorks CAD modelling software. Different printing techniques are used to fabricate desired 3D objects; among all these techniques, it is widely accepted that SLS is one of the most effective methods of 3D printing for fabricating drug-loaded solid oral dosage forms (SODFs) in bulk quantities using the single-step process. Different SODFs, such as pills, miniprintlets, dual miniprintlets, and tablets, were fabricated with different sizes and shapes. In this study, for the first time, we introduce SLS-mediated hollow capsular shells (HCSs) with the help of the SLS 3D printing technique. This work aimed to explore the sinterability and feasibility of sketching HCSs using the SLS-mediated sintering technique with different marketed sizes of capsules ranging from 000 to 5. Here, we have utilized Kolliphor P 188 (KP 188) and Kollidon SR (KSR) in a 1:1 ratio as a matrix-forming agent and 1% charcoal as a laser absorption-enhancing material. In accordance with the CAD models, we have fabricated the gradient conventional different sizes of HCSs ranging from 000 to 5 using the constant printing parameters and composition. Fabricated all biobased HCSs were subjected to the assessment of mechanistic and physicochemical parameters using varied analytical tools. In the current study, tartrazine dye is used to assess the release pattern from HCSs, which resulted in the modified release pattern. The adapted approach will be the futuristic approach to replace animal-based gelatin capsules with pharmaceutical-grade polymer-based HCSs with a modified release with optimum mechanical strength.

A frugal and innovative, intelligent messaging assistant - a futuristic approach

A frugal and innovative, intelligent messaging assistant - a futuristic approach

A frugal and innovative, intelligent messaging assistant - a futuristic approach

A frugal and innovative, intelligent messaging assistant - a futuristic approach

Effects of seed size and germination percentage with different treatments in Holoptelia integrifolia

Holoptelia integrifolia is an important tree of tropical and temperate regions owing to its uses as an afforestation tree as well as a traditional medicinal plant. A study was carried out to know variations in seed size and germination in seeds collected from various locations. Seeds from 13 locations in different parts of Rajasthan. Variation in seed size and germination percentage by using different treatments and plant growth regulators. Detailed results and a futuristic approach are presented in this paper.

Research of Organ-on-a-chip and its application

Material selection for Organ-on-a-Chip fabrication is a complex process, necessitating careful consideration of multiple factors. This comprehensive assessment involves detailed scrutiny of five materials—PDMS, glass, silicon, hydrogel, and PMMA—each accompanied by an intricate exploration of their specific properties. Moreover, thoroughly evaluating the associated costs contributes to the decision-making process, ensuring optimal material choices aligned with the intended applications. Furthermore, this discourse extends to an in-depth discussion of distinct organoids, including lung, liver, kidney, and skin chips. This comprehensive analysis delves into the principles underpinning their functionality, the intricate structures replicating organ features, and a forward-looking evaluation of their development prospects. By delving into the essence of each organoid, a holistic understanding of their potential in revolutionizing disease modeling, drug testing, and personalized medicine is elucidated. The narrative culminates in the introduction of the groundbreaking combined multi-organic chip system. This integration of various organoid models represents a significant stride towards emulating the interconnectedness of organs within the human body. This futuristic approach lays the foundation for a dynamic and intricate system that provides a holistic view of complex physiological interaction.

Surface modification of a biomass-derived self-supported carbon nano network as an emerging platform for advanced field emitter devices and supercapacitor applications.

Herein, a self-supported carbon network is designed through the sole pyrolysis of Carica papaya seeds (biomass) without any activation agent, demonstrating their field emission and supercapacitor applications. The pyrolysis of seeds in an argon atmosphere leads to the formation of interconnected, rod-like structures. Furthermore, the hydrofluoric acid treatment not only removed impurities, but also resulted in the formation of CaF2 nanocrystals with the addition of F-doping. From the field emission studies, the turn-on field values defined at an emission current density of ∼10 μA cm-2 were found to be ∼2.16 and 1.21 V μm-1 for the as-prepared carbon and F-doped carbon, respectively. Notably, F-doped carbon exhibits a high emission current density of ∼9.49 mA cm-2 and has been drawn at an applied electric field of ∼2.29 V μm-1. Supercapacitor studies were carried out to demonstrate the multi-functionality of the prepared materials. The F-doped carbon electrode material exhibits the highest specific capacitance of 234 F g-1 at 0.5 A g-1. To demonstrate the actual supercapacitor application, the HFC//HFC symmetric coin cell supercapacitor device was assembled. The overall multifunctional applicability of the fabricated hybrid structures provides a futuristic approach to field emission and energy storage applications.

Multi Modalities Medical Image Fusion Using Deep Learning and Metaverse Technology: Healthcare 4.0 A Futuristic Approach

Multimodal medical image fusion is the efficient integration of various imaging modalities to improve the ability to assess, direct therapy, treat patients, or predict outcomes. As image fusion offers additional essential information, the correctness of the image generated from different medical imaging modalities has a substantial impact on the success of a disease's diagnosis. A single medical imaging modality cannot provide complete and precise information. In the modern research area, multimodality medical image fusion approach is one of the meaningful research in the area of medical imaging and radiation medicine. The fusion of medical images is the process of enrolling and combining multiple images from one or more imaging modalities, enhancing the image quality and to achieve randomness and redundancy, heighten the clinical utility of medical images in the diagnosis and evaluation of medical problems. The thought is to enhance the image occurrence Magnetic resonance imaging (MRI) is achieved by combining images like computerized tomography (CT) as well as magnetic resonance imaging (MRI) gives fine soft tissue information as long as CT gives fine facts over denser tissue. In this research paper, we have an account that features for future development with demanding performance requirements and processing speed.

Machine Learning Mediated Advanced Phage and Antimicrobial Therapy- A Futuristic Approach

The emergence of antimicrobial resistance (AMR) has overwhelmed the contemporary curatives and have turned into one of the major challenges in the biomedical sector. With increasing deaths being associated with AMR every year; early detection of pathogens and development of novel drugs and alternative therapies, have all become ad hoc in diagnosis, prognosis and patient survival. Bacteriophage therapy remains a viable strategy to counteract AMR, yet unduly restrained by phage resistance. Phage infection is a natural phenomenon and can be widely manipulated in vitro using advanced techniques including the CRISPR/Cas systems which renders phage therapy an upper hand in comparison to conventional drugs. Phage identification, host range detection, determination of phage-receptor binding efficiency, adsorption rate, phage genome analysis are crucial stages in phage selection and phage cocktail preparation and moreover pivotal in flourishing phage therapy. The ascent of translational research and omics has allowed the development of quick, reliable and precise strategies for phage-based diagnosis and treatment techniques. However, in vitro evaluation of AMR and phage factors as well as storing, processing and analyzing large laboratory data outputs are expensive, time-consuming and labor-intensive. Machine learning (ML) is a utilitarian strategy to organize, store, analyze data sets and more importantly allows prediction of certain features by recognizing patterns in the data sets. With the huge number of research been carried out around the globe and enormous data sets being published and stored in databases, ML can utilize the available data to perform and guide in developing alternative therapeutics. Several ML based tools have been developed to predict resistance in host, phage grouping for cocktail preparation, resistance and lysogenic genes detection, phage genomic evaluation and to understand phage-host interactions. ML also allows the in silico analysis of large samples (drug/phage) and reduces sample size for in vitro evaluation thereby reducing overall costs, time and labor. The present review summarizes the available ML algorithms and corresponding databases used in AMR and phage research. It also emphasizes the status quo of antimicrobial and phage resistance in the healthcare sector and analyses the role of ML in analyzing biological databases in order to predict possible phage/drug-host interaction patterns, phage susceptibility, suitability of phage strains for therapy and recommends the most efficient drug combinations and treatment strategies.

Advocates of the Future: Challenges and Opportunities of Robot Lawyer in Indonesia

The digital age has brought significant changes in various sectors, including the legal field. The emergence of robot lawyers, or artificial intelligence (AI) in legal practice, offers unprecedented efficiency and accuracy. This study explores the potential impact of robot lawyers in the context of Indonesia's Advocates Law, considering legal, ethical, and practical aspects. This research applies the normative legal method, which combines statutory, conceptual, comparative, and futuristic approaches. The characteristics of this research are descriptive-prescriptive, where the data collected is analyzed using the content analysis method. This research shows that robot lawyers have the potential to improve access to legal services, reduce costs, and offer more consistent and unbiased solutions. However, challenges such as data security, legal liability, and ethical concerns related to replacing human labor with AI also arise. Further analysis shows that Indonesia's current Advocate Law is not fully prepared for the era of robot lawyers. This research recommends updating the policy and legal framework to effectively integrate AI in legal practice while maintaining the integrity of the profession and protecting the public interest. We also highlight the importance of adaptive legal education and training to prepare legal practitioners for technological change.

Ceria-Based Nanozymes in Point-of-Care Diagnosis: An Emerging Futuristic Approach for Biosensing.

In recent years, there has been a notable increase in interest surrounding nanozymes due to their ability to imitate the functions and address the limitations of natural enzymes. The scientific community has been greatly intrigued by the study of nanoceria, primarily because of their distinctive physicochemical characteristics, which include a variety of enzyme-like activities, affordability, exceptional stability, and the ability to easily modify their surfaces. Consequently, nanoceria have found extensive use in various biosensing applications. However, the impact of its redox activity on the enzymatic catalytic mechanism remains a subject of debate, as conflicting findings in the literature have presented both pro-oxidant and antioxidant effects. Herein, we creatively propose a seesaw model to clarify the regulatory mechanism on redox balance and survey possible mechanisms of multienzyme mimetic properties of nanoceria. In addition, this review aims to showcase the latest advancements in this field by systematically discussing over 180 research articles elucidating the significance of ceria-based nanozymes in enhancing, downsizing, and enhancing the efficacy of point-of-care (POC) diagnostics. These advancements align with the ASSURED criteria established by the World Health Organization (WHO). Furthermore, this review also examines potential constraints in order to offer readers a concise overview of the emerging role of nanoceria in the advancement of POC diagnostic systems for future biosensing applications.

Unraveling the contemporary use of microbial fuel cell in pesticide degradation and simultaneous electricity generation: a review.

Pesticide is an inevitable substance used worldwide to kill pests, but their indiscriminate use has posed serious complications to health and the environment. Various physical, chemical, and biological methods are employed for pesticide treatment, but this paper deals with microbial fuel cell (MFC) as a futuristic technology for pesticide degradation with electricity production. In MFC, organic compounds are utilized as the carbon source for electricity production and the generation of electrons which can be replaced with pollutants such as dyes, antibiotics, and pesticides as carbon sources. However, MFC is been widely studied for a decade for electricity production, but its implementation in pesticide degradation is less known. We fill this void by depicting a real picture of the global pesticide scenario with an eagle eye view of the bioremediation techniques implemented for pesticide treatment with phytoremediation and rhizoremediation as effective techniques for efficient pesticide removal. The enormous literature survey has revealed that not many researchers have ventured into this new arena of MFC employed for pesticide degradation. Based on the Scopus database, an increase in annual trend from 2014 to 2023 is observed for MFC-implemented pesticide remediation. However, a novel MFC to date for effective remediation of pesticides with simultaneous electricity generation is discussed for the first time. Furthermore, the limitation of MFC technology and the implementation of MFC and rhizoremediation as a clubbed system which is the least applied can be seen as promising and futuristic approaches to enhance pesticide degradation by bacteria and electricity as a by-product.

Herbal medicinal plants for the treatment of memory impairment: A futuristic approach for neurological Studies

Herbal medicinal plants for the treatment of memory impairment: A futuristic approach for neurological Studies

Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches.

Respirable particles are integral to effective inhalable therapeutic ingredient delivery, demanding precise engineering for optimal lung deposition and therapeutic efficacy. This review describes different physicochemical properties and their role in determining the aerodynamic performance and therapeutic efficacy of dry powder formulations. Furthermore, advances in top-down and bottom-up techniques in particle preparation, highlighting their roles in tailoring particle properties and optimizing therapeutic outcomes, are also presented. Practices adopted for particle engineering during the past 100 years indicate a significant transition in research and commercial interest in the strategies used, with several innovative concepts coming into play in the past decade. Accordingly, this article highlights futuristic particle engineering approaches such as electrospraying, inkjet printing, thin film freeze drying, and supercritical processes, including their prospects and associated challenges. With such technologies, it is possible to reshape inhaled therapeutic ingredient delivery, optimizing therapeutic benefits and improving the quality of life for patients with respiratory diseases and beyond.

Futuristic Novel Therapeutic Approaches in the Treatment of Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and joint destruction, leading to significant morbidity and reduced quality of life. Although significant progress has been made in the management of RA over the past few decades, many patients still fail to respond adequately to currently available therapies. This article aims to review the current landscape of RA treatment and explore potential novel therapeutic approaches that hold promise for the future. Advances in our understanding of the underlying pathogenesis of the disease have led to the identification of new targets and the development of innovative treatment strategies. This review focuses on emerging therapies including small molecule inhibitors, targeted biologics, cell-based therapies, and gene editing technologies that have shown potential in preclinical and early clinical trials. Additionally, we discuss the challenges and opportunities associated with the use of these new approaches in the treatment of RA. By elucidating the future of novel therapeutic approaches, this article provides insights that can guide clinicians and researchers in their efforts to improve outcomes for patients with RA.